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  4. Recombinant Rat Deoxyribonuclease gamma (Dnase1l3)

Recombinant Rat Deoxyribonuclease gamma (Dnase1l3)

  • 中文名稱：
    大鼠Dnase1l3重組蛋白
  • 貨號：
    CSB-YP007052RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Dnase1l3重組蛋白
  • 貨號：
    CSB-EP007052RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Dnase1l3重組蛋白
  • 貨號：
    CSB-EP007052RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Dnase1l3重組蛋白
  • 貨號：
    CSB-BP007052RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Dnase1l3重組蛋白
  • 貨號：
    CSB-MP007052RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Dnase1l3Deoxyribonuclease gamma; DNase gamma; EC 3.1.21.-; DNaseY; Deoxyribonuclease I-like 3; DNase I-like 3
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    26-310
  • 氨基酸序列
    LRLCS FNVRSFGESK KENHNAMDII VKIIKRCDLI LLMEIKDSNN NICPMLMEKL NGNSRRSTTY NYVISSRLGR NTYKEQYAFL YKEKLVSVKA KYLYHDYQDG DTDVFSREPF VVWFQAPFTA AKDFVIVPLH TTPETSVKEI DELADVYTDV RRRWKAENFI FMGDFNAGCS YVPKKAWKNI RLRTDPNFVW LIGDQEDTTV KKSTSCAYDR IVLRGQEIVN SVVPRSSGVF DFQKAYELSE EEALDVSDHF PVEFKLQSSR AFTNSRKSVS LKKKKKGSRS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity. Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation.
  • 基因功能參考文獻：
    1. DNase gamma plays an important role in Fas-independent apoptotic DNA fragmentation in hepatocytes. PMID: 15118903
    2. DNase gamma is suggested to be involved in naturally occurring apoptosis in developing nervous systems PMID: 15167901
  • 亞細胞定位：
    Nucleus. Secreted.
  • 蛋白家族：
    DNase I family
  • 組織特異性：
    Detected at high levels in spleen, lymph nodes, thymus and liver. Observed also in kidney and testis, but not in brain or heart.
  • 數據庫鏈接：


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