在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat DNA-binding protein inhibitor ID-1 (Id1)

Recombinant Rat DNA-binding protein inhibitor ID-1 (Id1)

  • 中文名稱：
    大鼠Id1重組蛋白
  • 貨號：
    CSB-YP010966RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Id1重組蛋白
  • 貨號：
    CSB-EP010966RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Id1重組蛋白
  • 貨號：
    CSB-EP010966RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Id1重組蛋白
  • 貨號：
    CSB-BP010966RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Id1重組蛋白
  • 貨號：
    CSB-MP010966RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Id1; Id-1; DNA-binding protein inhibitor ID-1; Inhibitor of DNA binding 1; Inhibitor of differentiation 1
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-164
  • 氨基酸序列
    MKVASSSAAA TAGPSCSLKA GRTAGEVVLG LSEQSVAISR CAGTRLPALL DEQQVNVLLY DMNGCYSRLK ELVPTLPQNR KVSKVEILQH VIDYIRDLQL ELNSESEVAT AGGRGLPVRA PLSTLNGEIS ALAAEVRSES EYYIILLWET KATGGGCPPY FSGA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
  • 基因功能參考文獻：
    1. Via RNAi, it was found that ID1 induction was inhibited with silencing of HIF-1alpha. Moreover, the suppression of ID1 mRNA expression could lead to decreased expression and transcription of HIF-1alpha during hypoxia and reoxygenation. In addition, it was demonstrated that both ID1 and HIF-1alpha can regulate the transcription of twist PMID: 27127787
    2. These results thus established a signaling cascade of "Abeta --> Id1 --> HIF-1 --> SHH" in primary rat cortical cultures; furthermore, SHH may in part contribute to amyloid beta neurotoxicity. PMID: 25502463
    3. Smad1 as a novel binding protein of KSHV latency-associated nuclear antigen (LANA). LANA interacted with and sustained BMP-activated p-Smad1 in the nucleus and enhanced its loading on the Id promoters. PMID: 25010525
    4. These data suggest that BMP4 may regulate survival through the Id1/EGFR pathway during development of the rat inner ear. PMID: 23335245
    5. Results suggest that the Id1/PI3K/Akt/NFkappaB/survivin signalling pathway plays a critical role in endothelial progenitor cell proliferation. PMID: 22139302
    6. Recombinant human bone morphogenetic protein 2 enhanced mesenchymal stem cell Id1 expression, required for vascular differentiation and spatial organisation, under normoxic conditions. PMID: 21472453
    7. Prostacyclin analogues inhibited smooth muscle cell proliferation and prevented progression of pulmonary hypertension while enhancing Smad1/5 phosphorylation and Id1 gene expression. PMID: 20522807
    8. the exclusion of Id-1 from GFAP-positive cells, and expression in a population of vimentin-positive pineal astrocytes is evidence of a role for Id-1 in the adult stabilization of one form of astrocyte PMID: 12495223
    9. Treatment of PC12 cells with recombinant Tat enhances the NGF-induced Id1 expression, further pointing to Id1 as a target for Tat. PMID: 15361847
    10. induced in the presence of Epstein-Barr virus LMP1 and confirmed by mRNA and protein in C33A and Rat-1 cells PMID: 15564458
    11. overexpression of ID1 and ID2 genes in a postmitotic, terminally differentiated cell type (Sertoli cells)have the capacity to induce reentry into the cell cycle PMID: 15647457
    12. ID-1 proteins play an important role in the development of acquired drug resistance to various drugs of prostate cancer cells. (Id-1) PMID: 15809768
    13. Expression of all 4 members of the Id family of transcription factors is differentially regulated in response to orchidectomy along the epididymis. PMID: 16304207
    14. A 31-bp sequence (Box-2 region), located between -200 and -169bp in the Id-1 promoter is necessary for the promoter activity. PMID: 16638616
    15. Drug resistant prostate cancer cells displayed significantly increased expression of ID1 compared with other prostate cancer PMID: 16728343
    16. The proliferative action of Id1 on the organ of Corti is mediated by nuclear factor-kappaB (NF-kappaB) and cyclin D1 in the embryonic cochlea. PMID: 17149750

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲综合无码精品一区二区三区| 伊人色合天天久久综合网| 色噜噜狠狠狠综合曰曰曰| 久久国产精品免费一区二区三区 | 欧美 变态 另类 人妖| 国产高清av在线播放| 忘忧草日本在线播放www| 多人伦交性欧美| 狠狠色狠狠色综合| 狠狠色丁香久久婷婷综合图片| 在线视频 亚太 国产 欧美 一区二区| 日韩亚洲国产高清免费视频| 久久久久99精品国产片| 日本少妇高潮喷水视频| 国产丝袜在线精品丝袜| 成人午夜特黄aaaaa片男男| 亚洲人成网站18禁止无码| 国产成人精品成人a在线观看 | 国产丰满人妻一区二区| 亚洲国产精品第一区二区| 精品国产免费一区二区三区香蕉| 热久久99这里有精品综合久久| 国产高清在线精品一区下载| 人妻少妇精品视频二区| 亚洲第一极品精品无码| 国产综合有码无码中文字幕| 精品人妻系列无码一区二区三区| 亚洲精品日韩一区二区电影| 2020最新无码国产在线观看| 无码加勒比一区二区三区四区| 国产成人久久精品77777综合| 无码av片av片av无码| 亚洲欧洲综合有码无码| 国产午夜手机精彩视频| 亚洲人成人无码网www国产| 国产高清不卡免费视频| 99久久人妻精品免费一区| 老外和中国女人毛片免费视频| 亚洲综合最新无码专区| 亚洲全部无码中文字幕| 国产乱人伦av在线无码|