在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Chondroitin sulfate proteoglycan 4 (Cspg4), partial

Recombinant Rat Chondroitin sulfate proteoglycan 4 (Cspg4), partial

  • 中文名稱：
    Recombinant Rat Chondroitin sulfate proteoglycan 4(Cspg4) ,partial
  • 貨號：
    CSB-YP006076RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat Chondroitin sulfate proteoglycan 4(Cspg4) ,partial
  • 貨號：
    CSB-EP006076RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat Chondroitin sulfate proteoglycan 4(Cspg4) ,partial
  • 貨號：
    CSB-BP006076RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat Chondroitin sulfate proteoglycan 4(Cspg4) ,partial
  • 貨號：
    CSB-MP006076RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Cspg4; Ng2; Chondroitin sulfate proteoglycan 4; Chondroitin sulfate proteoglycan NG2; HSN tumor-specific antigen
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.
  • 基因功能參考文獻：
    1. chondroitin sulfate proteoglycan 4 (CSPG4) is a potential mesenchymal progenitor cells marker. PMID: 27582000
    2. These findings indicate that Col VI provided a characteristic microenvironment in the GOR and that NG2-Col VI interactions may regulate the differentiation of osteoblast lineages prior to terminal maturation. PMID: 27498042
    3. studies suggest that proteoglycan-mediated entrapment upon NG2+ cells is an additional obstacle to CNS axon regeneration. PMID: 25471575
    4. our data suggested that NG2 proteoglycan expression and secretion hallmarked demarcation as a process that actively separated necrosis from vital tissue and therefore decisively impacts secondary neurodegeneration after ischemic stroke. PMID: 22640018
    5. In a transient 90-min middle cerebral artery occlusion (MCAO) model of rats, a large ischemic lesion is formed where macrophage-like cells massively accumulate, many of which express a macrophage marker, NG2 PMID: 19861972
    6. results indicate that NG2 mediates the induction of iNOS and inflammatory cytokine expression, but not the chemokine expression in activated microglia. PMID: 19878709
    7. NG2+ cells derived from the spinal cord following injury expressed high levels of laminin and fibronectin which promote neurite outgrowth. PMID: 20053907
    8. identified a novel repeat named CSPG in the central ectodomain PMID: 12220645
    9. Multiple protein domains of the NG2 proteoglycan inhibit neurite growth and induce growth cone collapse. PMID: 12514214
    10. The expression patterns and cell associations of inhibitory CSPG4 have important implications for axon regeneration across acute and chronic spinal cord scar tissue. PMID: 12526031
    11. NG2 is expressed by a distinct cell population in the mature central nervous system with the homogeneous antigenic phenotype of oligodendrocyte progenitors. PMID: 14572468
    12. After peripheral nerve injury in rats and humans, an accumulation of NG2-positive cells was observed at the injury site. In the rat, there was an increase in NG2 glycanation for at least 2 weeks following injury. PMID: 14664826
    13. Electroconvulsive seizures dramatically increased the proliferation of amygdala cells expressing the oligodendrocyte progenitor marker NG2. PMID: 15023573
    14. PKC-alpha-mediated NG2 phosphorylation at Thr(2256) is a key step for initiating cell polarization and motility PMID: 15504744
    15. Since NG2 loss in a rodent model of hypoxia-ischemia (H-I) occurs around the time of progressive cell death and appearance of the infarct, it may be that H-I rapidly induces a cellular response that actively depletes Ng2 from the hippocampal matrix. PMID: 15817274
    16. NG2 is expressed by all perivascular cells along arterioles, and its absence denotes a venule-specific phenotype PMID: 15824037
    17. Ectodomain shedding converts NG2 into a diffusible entity able to interact with the growth cone, and we suggest that this release is likely to enhance its axon growth-inhibitory activity PMID: 15866049
    18. These data suggest that NG2+ MG in normal developing or pathologic brains are involved in the genesis or regeneration of the brain. PMID: 16534776
    19. NG2 proteoglycan expression is transiently upregulated along venules during microvascular remodeling PMID: 16627368
    20. These results suggest that NG2 positive cells which derived from subpial layer, may have some lineage to RG after SCI in adult rodents. PMID: 16902766
    21. We propose that during development NG2(+)/A2B5(-) cells (pre-OPCs) represent the direct ancestor to A2B5(+) O2A progenitor cells (OPCs). PMID: 17503442
    22. Differential phosphorylation of NG2 proteoglycan by ERK and Pkca helps balance cell proliferation and cell movement. PMID: 17591920
    23. NG2 participates in the development and progression of glomerulosclerosis by stimulating proliferation of mesangial cells and deposition of extracellular matrix. PMID: 17686464

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein; Extracellular side. Apical cell membrane; Single-pass type I membrane protein; Extracellular side. Cell projection, lamellipodium membrane; Single-pass type I membrane protein; Extracellular side. Cell surface.
  • 組織特異性：
    Neural cells and also extraneural tissues, especially in the developing mesenchyme.
  • 數據庫鏈接：


主站蜘蛛池模板： 国产乱子伦精品免费视频| 国产口爆吞精在线视频2020版| 国产熟妇久久777777| 插我舔内射18免费视频| 岛国4k人妻一区二区三区| 国产99视频精品免费观看9| 熟女视频一区二区在线观看 | 亚洲国产中文在线视频| 吸咬奶头狂揉60分钟视频| 国产精品igao视频网网址| 久久精品成人免费国产片小草| 成人国产精品秘片多多| 狠狠97人人婷婷五月| 中文字幕一区二区三区精华液| 无码h肉动漫在线观看免费 | 亚洲熟妇av午夜无码不卡| 黑人大战日本人妻嗷嗷叫不卡视频| 欧美肥婆姓交大片| 狠狠躁日日躁夜夜躁2022麻豆| a狠狠久久蜜臀婷色中文网| 99久久99视频只有精品| 2019日韩中文字幕mv| 2020无码专区人妻系列日韩| 老司机导航亚洲精品导航| 国产精品午夜成人免费观看| 中文字幕被公侵犯的漂亮人妻 | 在线看片无码永久av| 一区二区视频日韩免费| 伊人久久亚洲综合影院首页| 欧美激情精品久久| av无码中文一区二区三区四区| 国产sp调教打屁股视频网站| 国产精品永久久久久久久久久| 日本少妇裸体做爰高潮片| 精品国内自产拍在线播放观看| 少妇呻吟白浆高潮啪啪69| 欧美性猛交xxxx黑人猛交 | 乱中年女人伦av三区| 人妻无码一区二区三区 tv| 欧美综合自拍亚洲综合区| 国产真实的和子乱拍在线观看|