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  4. Recombinant Rat Attractin (Atrn), partial

Recombinant Rat Attractin (Atrn), partial

  • 中文名稱：
    Recombinant Rat Attractin(Atrn) ,partial
  • 貨號：
    CSB-YP002435RA
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat Attractin(Atrn) ,partial
  • 貨號：
    CSB-EP002435RA
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat Attractin(Atrn) ,partial
  • 貨號：
    CSB-EP002435RA-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat Attractin(Atrn) ,partial
  • 貨號：
    CSB-BP002435RA
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat Attractin(Atrn) ,partial
  • 貨號：
    CSB-MP002435RA
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Atrn
  • Uniprot No.：
  • 別名：
    AtrnAttractin; Protein zitter
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti. Has a critical role in normal myelination in the central nervous system.
  • 基因功能參考文獻：
    1. This study indicated that myelinogenesis but not oligodendrogenesis is severely altered both in the white and gray matter of attractin-deficient mv rats. PMID: 19931230
    2. There is myelin vacuolation in rats with a null mutation in the gene. PMID: 12379762
    3. Lack of Attractin gene expression induced neurodegeneration by a decrease in active ERK through an intracellular signaling via oxidative stress. PMID: 12654511
    4. Attractin defects result in oligodendrocyte dysfunction, and is associated with astrogliosis and microglial activation in mutant rats; attractin may be directly involved in the function of oligodendrocytes in CNS myelination. PMID: 18206135
    5. Atrn is more widely expressed throughout the CNS than previously reported, and expression of Atrn by various cell types suggests that Atrn may serve multiple functions in the CNS. PMID: 18302151

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  • 相關疾病：
    Defects in Atrn (isoform 1) are the cause of the autosomal recessive phenotype zitter (zi), which is characterized by progressive hypomyelination and vacuolation in the central nervous system resulting in early-onset tremor and progressive flaccid paresis of the hind limb. This is due to an 8-bp deletion at the splice donor site of intron 12, which results in aberrant and unstable transcripts.
  • 亞細胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
  • 數據庫鏈接：


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