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  4. Recombinant Rat ATP-binding cassette sub-family C member 9 (Abcc9), partial

Recombinant Rat ATP-binding cassette sub-family C member 9 (Abcc9), partial

  • 中文名稱：
    Recombinant Rat ATP-binding cassette sub-family C member 9(Abcc9) ,partial
  • 貨號：
    CSB-YP730907RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat ATP-binding cassette sub-family C member 9(Abcc9) ,partial
  • 貨號：
    CSB-EP730907RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat ATP-binding cassette sub-family C member 9(Abcc9) ,partial
  • 貨號：
    CSB-EP730907RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat ATP-binding cassette sub-family C member 9(Abcc9) ,partial
  • 貨號：
    CSB-BP730907RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat ATP-binding cassette sub-family C member 9(Abcc9) ,partial
  • 貨號：
    CSB-MP730907RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Abcc9; Sur2ATP-binding cassette sub-family C member 9; Sulfonylurea receptor 2
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
  • 基因功能參考文獻：
    1. These data provide insights into the molecular basis by which phosphorylation of SUR2B NBD1 activates KATP channels. PMID: 26198630
    2. Electrophysiological studies employing SUR2A/Kir6.2-expressing HEK cells showed that increasing endogenous or exogenous Phosphatidylinositol 4,5-bisphosphate diminished the inhibitory effect of Syn-1A on KATP currents. PMID: 25073062
    3. Testosterone protect female embryonic heart H9c2 cells against severe metabolic stress by its conversion into metabolites that activate estrogen receptors and up-regulate IES SUR2B. PMID: 23085378
    4. mRNA & protein of SUR2A & SUR2B are expressed in whole rat brain extracts & selected regions. SUR2B to be localized in astrocytes and oligodendrocytes, while SUR2A is only localized in oligodendrocytes. PMID: 22960600
    5. Electron microscopy revealed that SUR2B assmbles as a tetramer of four subunits surrounding a central hole. PMID: 23253866
    6. SUR2 helped to regulate the proliferation and differentiation of preadipocytes. Glibenclamide inhibited the expression of SUR2 mRNA in preadipocytes. PMID: 17294036
    7. Both mRNA and protein expression of cardiac K-ATP (SUR2A/Kir6.2) channels are decreased in diabetic rats. PMID: 22257425
    8. The paper identified a protein kinase A phosphorylation site on SUR2B subunit (Ser1387) and suggests it is required for Kir6.1/SUR2B channel activation by beta-adrenergic receptors. PMID: 17596331
    9. The boundaries of the first nucleotide-binding domain of SUR2A have been determined from samples of folded and functional protein that provide a platform for insight into the role of SUR2A in regulating KATP channel activity. PMID: 21714514
    10. The novel cGMP/PKG/ROS/calmodulin/CaMKII signaling pathway may regulate cardiomyocyte excitability by opening K(ATP) channels and contribute to cardiac protection against ischemia-reperfusion injury. PMID: 21479273
    11. ATP-sensitive potassium channels might be involved in the proliferation and differentiation of rat preadipocytes by changing the expression of P21, P27 and leptin. PMID: 19224154
    12. ATP-sensitive potassium channels containing different SUR2 isoforms are differentially modulated by MgATP, with Kir6.2/SUR2B being activated more than Kir6.2/SUR2A. Purified SUR2B has a lower ATPase activity and a 10-fold lower K(m) for MgATP than SUR2A. PMID: 20553499
    13. SUR2A is important for coupling cardiac K(ATP) channels to caveolin-3, possibly through the caveolin-3 scaffolding domain. PMID: 20332621
    14. Data suggest that AV-SUR2A increases resistance to metabolic stress in H9C2 cells by increasing the number of sarcolemmal K(ATP) channels and subsarcolemmal ATP. PMID: 20123112
    15. M-LDH physically associated with Kir6.2/SUR2A regulates the activity of sarcolemmal K(ATP) channels as well as an intracellular ATP production during metabolic stress, both of which are important for cell survival. PMID: 19464385
    16. Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in the absence of SUR2B. PMID: 11927600
    17. mesangial SUR2B as the possible first link in a chain of cellular events that culminates in MC contraction and altered extracellular matrix metabolism following exposure to sulfonylureas. PMID: 11967023
    18. KATP channels consist of 4 sulfonylurea receptors interacting with 4 channel subunits. Expression of SUR2B mRNA was seen in cultured basilar arterial muscle cells. Kir6.1/SUR2B may be the major potassium channel mediating propionate-induced dilatation. PMID: 12677015
    19. There is a site in the C-terminal domain of rSUR2A, between residues 1294 and 1358, whose direct interaction with full-length Kir6.2 is crucial for the assembly of functional KATP channels. PMID: 14672537
    20. Syn-1A binds both NBFs of SUR1 and SUR2A but appears to exhibit distinct interactions with NBF2 of these SUR proteins in modulating the KATP channels in islet beta cells and cardiac myocytes PMID: 15339904
    21. Syntaxin-1A actions on sulfonylurea receptor 2A blocks acidic pH-induced cardiac K(ATP) channel activation PMID: 16672225
    22. SUR2A and SUR2B are not only the regulatory subunits of sarcolemmal K(ATP) channels but may also function as regulatory subunits in mitochondrial K(ATP) channels and play important roles in cardioprotection PMID: 17438353
    23. ATP binds to SUR subunit of K-ATP channel to allosterically regulate binding of Rhodamne 123 to Kir6.2 subunit. PMID: 17510180
    24. This study showed that F333 in Kir6.2 interacts functionally with SUR2A to modulate channel rundown and MgADP activation. PMID: 17855752
    25. cAMP-dependent protein kinase phosphorylation produces interdomain movement in SUR2B leading to activation of the vascular KATP channel.( PMID: 18198173
    26. regulatory subunits of the K(ATP) channel in the rat kidney are SUR2A and SUR2B PMID: 18323694
    27. Our data demonstrate direct evidence of decreased aortic sur2 subunit expression in hypertension PMID: 18471810

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  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
  • 組織特異性：
    Expressed at high levels in heart, skeletal muscle and ovary. Moderate levels are found in brain, tongue and pancreatic islets. Low levels are found in lung, testis and adrenal gland. Expressed at very low levels in stomach, colon, thyroid and pituitary.
  • 數據庫鏈接：

    KEGG: rno:25560

    UniGene: Rn.10528



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