在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), partial

Recombinant Rat 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), partial

  • 中文名稱：
    大鼠Hmgcr重組蛋白
  • 貨號：
    CSB-YP010565RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Hmgcr重組蛋白
  • 貨號：
    CSB-EP010565RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Hmgcr重組蛋白
  • 貨號：
    CSB-EP010565RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Hmgcr重組蛋白
  • 貨號：
    CSB-BP010565RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Hmgcr重組蛋白
  • 貨號：
    CSB-MP010565RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Hmgcr; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase; EC 1.1.1.34
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis.
  • 基因功能參考文獻：
    1. This study is aiming to investigate the inhibition role of quercetin on hydroxy methyl glutarate - CoA reductase activity and its gene for attenuating hypercholesterolemia. PMID: 28938515
    2. findings demonstrate for the first time that strain-dependent sex difference in serum Total Cholesterol level between F344 and SD rats is, at least in part, related to difference in the IL-1alpha-mediated HMGR gene expression level in the liver. PMID: 24694611
    3. HMGCR expression is reduced in the liver of rats exposed to simvaglyzin and atorvaglyzin. PMID: 24319730
    4. investigated 3-hydroxy 3-methylglutaryl coenzyme A reductase and LDLr in adult (3-month-old) and aged (12-month-old) male and female rats in four different brain regions PMID: 23280554
    5. These findings indicate a role for TTP in the insulin-mediated activation of hepatic HMGR transcription. PMID: 22405826
    6. beta-ionone may inhibit cell proliferation and modulate HMGCoA reductase during rat hepatocarcinogenesis promotion. PMID: 20435455
    7. correlation between estrogen and HMGR short-term regulation suggests the presence of another mechanism underlying the protective role of estrogen in age-related diseases PMID: 19895880
    8. enhanced cholesterol biosynthesis, observed in experimental chronic renal failure, is at least in part due to increased HMG-CoA reductase gene expression PMID: 12841361
    9. 3-hydroxy-3-methylglutaryl-CoA reductase is ubiquinated in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase PMID: 15090540
    10. Upregulation of HMG-CoA reductase by myristic or eicosapentaenoic acid in hepatoma cells is caused by increased translation. PMID: 15337832
    11. These findings support the hypothesis that a different arrangement of the HMG-CoA reductase membrane domain in aged rats is a cause of reductase deregulation. PMID: 15491682
    12. Co-immunoprecipitation studies revealed that the amount of ubiquitin associated with the reductase was entirely dependent upon the amount of microsomal protein subjected to immunoprecipitation PMID: 15919082
    13. Data show that ezetimibe lowers serum cholesterol in animals with low rates of hepatic cholesterol synthesis and produces large compensatory increases in hepatic HMG-CoA reductase expression without affecting expression of hepatic LDL receptors. PMID: 16636304
    14. obtained data represent a good contribution to explain the age-related hypercholesterolemia PMID: 16741953
    15. Deletion of the region containing the cyclic AMP response element (CRE) at -104 to -96 and an NF-Y site at -70 to -65 resulted in marked reduction of promoter activity. PMID: 17327468
    16. Reactive oxygen species effect on the HMG-CoAR dephosphorylation is mediated by the activation of p38/MAPK pathway. PMID: 18031790
    17. Data show that (i) HMG-CoA reductase is crucial for differentiation induction, (ii) p21waf rises downstream of HMG-CoAR activation, (iii) p38/MAPK is key regulator for HMG-CoAR. PMID: 19388010
    18. These data provide in vivo evidence for functional roles for USF-2, SREBP-2, and NF-Y in mediating the T3-induction of hepatic HMGR transcription. PMID: 19470373

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    HMG-CoA reductase family
  • 數據庫鏈接：


主站蜘蛛池模板： 极品少妇高潮到爽| 亚洲精品久久yy5099| 四虎国产精品永久地址49| 亚洲愉拍99热成人精品热久久 | 国产三级aⅴ在在线观看| 人妻少妇精品久久| 欧美精品亚洲精品日韩传电影| 97久久久人妻一区精品| 色丁狠狠桃花久久综合网| 国产人成午夜免电影费观看| 天堂www中文在线资源| 欧美牲交a欧美牲交aⅴ免费下载| 极品无码av国模在线观看| 人妻无码熟妇乱又伦精品视频| 日韩激情无码不卡码| 国产一区二区在线视频| 亚洲a∨国产av综合av网站| 国产亚洲精品a久久777777 | 风韵丰满熟妇啪啪区老熟熟女| 亚洲精品久久久久久婷婷| 国产午夜福利精品一区| 国产在线视频一区二区三区| 国模叶桐尿喷337p人体| 午夜男女无遮挡拍拍视频| 久久精品亚洲精品国产色婷| 国产av国片精品一区二区| 免费人成在线观看网站| 亚洲中文字幕无码一区在线 | 色欲av亚洲一区无码少妇| 国产麻豆精品一区| 国产精品成人a区在线观看| 国产主播一区二区三区在线观看| 极品美女扒开粉嫩小泬图片| 日韩欧美高清dvd碟片| 人妻无码中文字幕一区二区三区| 国产明星裸体xxxx视频| 久久久精品免费| 久久精品无码一区二区无码| 国产精品爽爽久久久久久无码| 亚洲国产精品久久久久久久| 国产成人av大片大片在线播放|