在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rabbit Protein kinase C epsilon type (PRKCE), partial

  • 中文名稱:
    小圓錐花果PRKCE重組蛋白
  • 貨號:
    CSB-YP018704RB
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小圓錐花果PRKCE重組蛋白
  • 貨號:
    CSB-EP018704RB
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小圓錐花果PRKCE重組蛋白
  • 貨號:
    CSB-EP018704RB-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小圓錐花果PRKCE重組蛋白
  • 貨號:
    CSB-BP018704RB
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小圓錐花果PRKCE重組蛋白
  • 貨號:
    CSB-MP018704RB
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    PRKCEProtein kinase C epsilon type; EC 2.7.11.13; nPKC-epsilon
  • 種屬:
    Oryctolagus cuniculus (Rabbit)
  • 蛋白長度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells.
  • 基因功能參考文獻(xiàn):
    1. Activation of PKC induces the translocation of Nrf2 and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart. PMID: 23010891
    2. in contrast to protective effects of PKC-epsilon activation in cardiomyocytes, sustained PKC-epsilon activation is detrimental to mitochondrial function and viability in renal proximal tubule cells PMID: 21289057
    3. Preferential glucose utilization by PKCepsilon hearts is orchestrated by a p-GSK3beta/HIF-1alpha-mediated mechanism. PMID: 21660969
  • 亞細(xì)胞定位:
    Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cytoplasm, perinuclear region. Nucleus.
  • 蛋白家族:
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 亚洲综合精品第一页| 免费萌白酱国产一区二区三区| 西西人体44www大胆无码| 免费国产h视频在线观看| 国产乱子伦一区二区三区视频播放| 日本丶国产丶欧美色综合 | 国产精品无码翘臀在线观看| 亚洲精品一区二区三区在线观看 | 无码办公室丝袜ol中文字幕| 国产精品久久久久久久| 亚洲午夜无码极品久久| av永久天堂一区| 国精产品一区一区三区mba下载 | 国产麻豆 9l 精品三级站| 天堂网www天堂资源网| 亚洲国产精久久久久久久| 无码人妻精品一区二区在线视频 | 99热亚洲色精品国产88| 他掀开裙子把舌头伸进去添视频 | 亚洲精品乱码久久久久久日本| 男女车车的车车网站w98免费| 成·人免费午夜无码视频蜜芽| 国产精品成人免费视频网站京东 | 玖玖资源站最稳定网址| 人人澡人人妻人人爽人人蜜桃麻豆| 国产老熟妇精品观看| 欧美最猛性xxxxx免费| 成人免费无遮挡在线播放| 亚洲伊人久久精品酒店| 99国产精品久久久久久久日本竹| 国产探花在线精品一区二区| 日本高清在线www3344| 无码人妻精品一二三区免费| 久久伊人色av天堂九九| 无码天堂亚洲国产av麻豆| 国产欧美亚洲日韩图片| 忍不住的亲子中文字幕| 亚洲色大网站www永久网站| 日本 精品 高清不卡| 大乳丰满人妻中文字幕日本| 乱人伦中文字幕成人网站在线|