在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Pig Sialoadhesin (SIGLEC1), partial

Recombinant Pig Sialoadhesin (SIGLEC1), partial

  • 中文名稱：
    野豬SIGLEC1重組蛋白
  • 貨號：
    CSB-YP021293PI
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    野豬SIGLEC1重組蛋白
  • 貨號：
    CSB-EP021293PI-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    野豬SIGLEC1重組蛋白
  • 貨號：
    CSB-BP021293PI
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    野豬SIGLEC1重組蛋白
  • 貨號：
    CSB-MP021293PI
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SIGLEC1
  • Uniprot No.：
  • 別名：
    SIGLEC1; SA; SNSialoadhesin; pSn; Sialic acid-binding Ig-like lectin 1; Siglec-1; p210
  • 種屬：
    Sus scrofa (Pig)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis. Acts as an endocytic receptor mediating clathrin dependent endocytosis. In case of porcine reproductive and respiratory syndrome virus (PRRSV), mediates virion attachment and internalization into alveolar macrophages through a clathrin-coated dependent process.
  • 基因功能參考文獻：
    1. the transcription initiation site for sialoadhesin (Siglec-1), which is a porcine alveolar macrophage-specific gene, was determined by 5' rapid amplification of cDNA end. PMID: 25501171
    2. Fusion protein of sialoadhesin and domains 5-9 of CD163 receptors blocked the respiratory syndrome virus infection. PMID: 24246307
    3. European genotype porcine reproductive and respiratory syndrome virus inhibits porcine alveolar macrophages phagocytosis in vitro, through the interaction with its internalization receptor sialoadhesin. PMID: 22630829
    4. After infection, PRRSV viremia in SIGLEC1(-/-) pigs followed the same course as in SIGLEC1(-/+) and SIGLEC1(+/+) littermates. The absence of SIGLEC1 had no effect on other aspects of PRRSV infection, including disease course and histopathology. PMID: 23785195
    5. Endodomain-deletion mutants of sialoadhesin promoted porcine reproductive and respiratory syndrome virus infection less efficiently. PMID: 23740482
    6. ). These results provided fundamental evidence for CD163 and SN as two functional candidate genes affecting immunity in pigs. PMID: 21786159
    7. effect of antibody binding to pSn on macrophage viability, phagocytosis of microspheres, uptake and processing of soluble antigens, reactive oxygen/nitrogen species production, MHC I and MHC II cell surface expression and cytokine production PMID: 21944562
    8. Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages. PMID: 21359217
    9. The present study demonstrates that the first domain at the N-terminus of Sn mediates porcine reproductive and respiratory syndrome virus (PRRSV) attachment to macrophages. PMID: 19969429
    10. These data show that the sialic acid-binding activity of pSn is essential for PRRSV attachment to pSn and thus identifies the variable, N-terminal domain of Sn as a PRRSV binding domain. PMID: 17567703
    11. Sialoadhesin is confirmed as a PRRSV (porcine reproductive and respiratory syndrome virus)internalization receptor and is shown to interact with CD163 in PRRSV entry. PMID: 19008379
    12. Clear changes in the quantity of sialoadhesin(+) and CD163(+) macrophages in the placentas and organs of embryos/fetuses during gestation. PMID: 19410291

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
  • 數據庫鏈接：

    KEGG: ssc:397623

    UniGene: Ssc.17338



主站蜘蛛池模板： 7878成人国产在线观看| 久久精品一区二区三区中文字幕| 少妇真实被内射视频三四区| 免费刺激性视频大片区| 亚色九九九全国免费视频| 久久99精品久久久久久不卡| 国产又色又爽又黄刺激在线视频| 国产精品宾馆精品酒店| 无码av免费一区二区三区四区| 国产三级在线观看播放视频| 99香蕉国产精品偷在线观看| 亚洲性无码av中文字幕| 99久久免费国产精品四虎| 国产午夜鲁丝片av无码| 精品国产av 无码一区二区三区 | 亚洲bbw性色大片| 人妻体内射精一区二区三区| 乱人伦中文视频在线| 国产乱人伦偷精品视频aaa| 婷婷伊人五月尤物| 狼人无码精华av午夜精品| 国产精品亚洲精品日韩已满| 香蕉97超级碰碰碰免费公开| 久久久国产精品黄毛片| 中国大陆高清aⅴ毛片| 国产成人亚洲精品无码蜜芽| 中文字幕在线不卡精品视频99| 亚洲欭美日韩颜射在线二| 深夜福利啪啪片| 西西人体大胆扒开下部337卩| 综合亚洲桃色第一影院| 国产不卡视频一区二区三区| 久久香蕉综合色一综合色88| 婷婷伊人久久大香线蕉av| 国产成年无码久久久久下载 | 欲色影视天天一区二区三区色香欲 | 亚洲精品久久久久久久久久久捆绑| 樱桃视频影视在线观看免费| 欧美人妻久久精品| 成人网站免费高清视频在线观看| 熟妇人妻无码中文字幕|