在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Pig Mothers against decapentaplegic homolog 4 (SMAD4), partial

Recombinant Pig Mothers against decapentaplegic homolog 4 (SMAD4), partial

  • 中文名稱：
    野豬SMAD4重組蛋白
  • 貨號：
    CSB-YP884388PI
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    野豬SMAD4重組蛋白
  • 貨號：
    CSB-EP884388PI
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    野豬SMAD4重組蛋白
  • 貨號：
    CSB-EP884388PI-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    野豬SMAD4重組蛋白
  • 貨號：
    CSB-BP884388PI
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    野豬SMAD4重組蛋白
  • 貨號：
    CSB-MP884388PI
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    SMAD4; MADH4; Mothers against decapentaplegic homolog 4; MAD homolog 4; Mothers against DPP homolog 4; SMAD family member 4; SMAD 4; Smad4
  • 種屬：
    Sus scrofa (Pig)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8.
  • 基因功能參考文獻：
    1. Activated TGF-beta signaling rescued miR-143-reduced FSHR and intracellular signaling molecules, and miR-143-induced porcine granulosa cell apoptosis. PMID: 27882941
    2. miR26b may have a proapoptotic role in granulosa cells by regulating SMAD4 expression. PMID: 25395673
    3. These observations establish an important role of SMAD4 in the regulation of the response of porcine granulosa cells to FSH. PMID: 21292728
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Dwarfin/SMAD family
  • 數據庫鏈接：


主站蜘蛛池模板： 成年无码动漫av片在线尤物| 国产高清视频在线观看97| 乱码精品一区二区三区 | 欧美人妻aⅴ中文字幕| 激情偷乱人伦小说视频在线| 欧美xxxx做受欧美| 无码少妇精品一区二区免费动态| 日韩精品无码免费一区二区三区| 国产精品久久久久久tv| 国产成人国产在线观看| 最近2019免费中文第一页| 疯狂做受xxxx高潮视频免费| 日韩免费无码一区二区视频| 男女爽爽午夜18污污影院| 黑人与人妻无码中字视频| 国产欧美va欧美va香蕉在线| 天躁夜夜躁狼狠躁| 国产精品久久久久蜜臀| av蓝导航精品导航| 国产亚洲人成无码网在线观看| 人人妻人人澡av天堂香蕉| 正在播放老肥熟妇露脸| 亚洲精品v天堂中文字幕| 国产一区二区三区在线视頻| 亚洲乱码中文字幕综合234| 男人j进女人p免费视频| 亚洲男同志网站| 亚洲精品久久久久久久观小说| 在线不卡av片免费观看| 精品香蕉99久久久久网站| 97人人模人人爽人人少妇| 无码av中文字幕免费放| 伊人久久大香线蕉综合bd高清| 久久国产乱子伦精品免费台湾| 少妇中文字幕乱码亚洲影视| 人妻无码一区二区不卡无码av| 亚洲精品久久一区二区三区四区| 欧美日韩国产专区一区二区| 亚洲另类激情综合偷自拍图| 熟妇女人妻丰满少妇中文字幕| 国产日韩欧美久久久精品图片|