在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Pig Heat shock 70 kDa protein 1A (HSPA1A), partial

  • 中文名稱:
    野豬HSPA1A重組蛋白
  • 貨號:
    CSB-YP010821PI
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    野豬HSPA1A重組蛋白
  • 貨號:
    CSB-EP010821PI
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    野豬HSPA1A重組蛋白
  • 貨號:
    CSB-EP010821PI-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    野豬HSPA1A重組蛋白
  • 貨號:
    CSB-BP010821PI
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    野豬HSPA1A重組蛋白
  • 貨號:
    CSB-MP010821PI
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    HSPA1A; HSPA1Heat shock 70 kDa protein 1A; Heat shock 70 kDa protein 1; HSP70.1
  • 種屬:
    Sus scrofa (Pig)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation. Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle. Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response.
  • 亞細胞定位:
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Secreted.
  • 蛋白家族:
    Heat shock protein 70 family


主站蜘蛛池模板: 国产精品亚洲五月天高清| 日本两人免费观看的视频| 久久精品国产精油按摩| 韩国午夜福利片在线| 精品亚洲国产成人av制服| 午夜视频在线观看免费完整版| 经典三级欧美在线播放| 欧美人与动牲交免费观看| 男人猛吃奶女人爽视频| 97久久超碰国产精品2021| 女的被弄到高潮娇喘喷水视频| 国产亚洲精品久久久久5区| 久久九九精品国产综合喷水| 少妇扒开双腿让我看个够| 伊人精品成人久久综合97| 精人妻无码一区二区三区| 全黄性性激高免费视频| 国产又粗又猛又大爽老大爷| 韩国午夜福利片在线观看| 亚洲国产精品久久久天堂不卡海量 | 寂寞骚妇被后入式爆草抓爆| 成年奭片免费观看视频天天看| 久久99亚洲精品久久69| 日韩人妻无码精品-专区| 18禁裸体动漫美女无遮挡网站| 国产精品久久久久久久| 中国xxxx做受视频| 邻居少妇张开腿让我爽了一夜| 久久国产人妻一区二区| 一区二区在线 | 欧洲| 日韩人妻熟女中文字幕a美景之屋| 失禁潮痉挛潮喷av在线无码| 国偷自产一区二区三区在线视频| 久久精品伊人久久精品伊人| 国产高潮视频在线观看| 国产精品免费一区二区三区四区| 开心五月综合亚洲| 国产精品aⅴ在线观看| 亚洲第一页综合图片自拍| 无码精品人妻一区二区三区免费看 | 亚洲成在人网站无码天堂|