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  4. Recombinant Pig Carbonyl reductase [NADPH] 1 (CBR1)

Recombinant Pig Carbonyl reductase [NADPH] 1 (CBR1)

  • 中文名稱：
    Recombinant Pig Carbonyl reductase [NADPH] 1(CBR1)
  • 貨號：
    CSB-YP635714PI
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Pig Carbonyl reductase [NADPH] 1(CBR1)
  • 貨號：
    CSB-EP635714PI
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Pig Carbonyl reductase [NADPH] 1(CBR1)
  • 貨號：
    CSB-EP635714PI-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Pig Carbonyl reductase [NADPH] 1(CBR1)
  • 貨號：
    CSB-BP635714PI
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Pig Carbonyl reductase [NADPH] 1(CBR1)
  • 貨號：
    CSB-MP635714PI
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CBR1
  • Uniprot No.：
  • 別名：
    CBR1; CBR; CRNCarbonyl reductase [NADPH] 1; EC 1.1.1.184; 15-hydroxyprostaglandin dehydrogenase [NADP(+)]; EC 1.1.1.197; 20-beta-hydroxysteroid dehydrogenase; NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase; EC 1.1.1.189
  • 種屬：
    Sus scrofa (Pig)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-289
  • 氨基酸序列
    SSNTRVALV TGANKGIGFA IVRDLCRQFA GDVVLTARDV ARGQAAVKQL QAEGLSPRFH QLDIIDLQSI RALCDFLRKE YGGLDVLVNN AAIAFQLDNP TPFHIQAELT MKTNFMGTRN VCTELLPLIK PQGRVVNVSS TEGVRALNEC SPELQQKFKS ETITEEELVG LMNKFVEDTK NGVHRKEGWS DSTYGVTKIG VSVLSRIYAR KLREQRAGDK ILLNACCPGW VRTDMGGPKA PKSPEVGAET PVYLALLPSD AEGPHGQFVT DKKVVEWGVP PESYPWVNA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
  • 基因功能參考文獻：
    1. NF-kappaB (p65) could bind to the special element of CBR1 gene promoter in porcine endometrial epithelial cells in vitro PMID: 28681587
    2. two Cys residues, Cys 149 and Cys 226, are involved in the enzyme activity; Cys 226 is involved in binding of the cofactor NADPH. PMID: 15145449
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 組織特異性：
    Expressed in kidney (at protein level).
  • 數據庫鏈接：

    KEGG: ssc:397143

    UniGene: Ssc.55707



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