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  4. Recombinant Caenorhabditis elegans Peptide transporter family 1 (pept-1), partial

Recombinant Caenorhabditis elegans Peptide transporter family 1 (pept-1), partial

  • 中文名稱：
    秀麗隱桿線蟲pept-1重組蛋白
  • 貨號：
    CSB-YP633658CXY
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲pept-1重組蛋白
  • 貨號：
    CSB-EP633658CXY
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲pept-1重組蛋白
  • 貨號：
    CSB-EP633658CXY-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲pept-1重組蛋白
  • 貨號：
    CSB-BP633658CXY
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲pept-1重組蛋白
  • 貨號：
    CSB-MP633658CXY
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    pept-1
  • Uniprot No.：
  • 別名：
    pept-1; cptb; opt-2; pep-2; K04E7.2; Peptide transporter family 1; Di-/tri-peptide transporter CPTB; Oligopeptide transporter 1
  • 種屬：
    Caenorhabditis elegans
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Low-affinity peptide transporter that is necessary for proton-dependent uptake of di- or tripeptides, and to a minor extent tetrapeptides, in the intestine. Transport is independent of sodium and chloride ions. Controls the uptake of dietary fatty acids, plays a role in fatty acid synthesis and is responsible for dipeptide-induced acidification of the intestine. Regulates cellular pH differences together with the antiporter protein, nhx-2. Amino acid uptake and absorption levels influence the insulin signaling/daf-2 and let-363/TOR pathways, subsequently affecting the stress response and longevity of the organism. It is required for the uptake of the L-enantiomers of various amino acids, including L-glutamate. In response to the availability of amino acid nutrients, may play a role in promoting reproduction and fertility.
  • 基因功能參考文獻：
    1. intracellular peptide hydrolysis and amino acid concentration are a part of a sensing system that controls PEPT-1 expression and function and that involves the TOR complexes TORC1 and TORC2 [PEPT-1][TORC1][TORC2] PMID: 21980510
    2. Intestinal amino acid availability via PEPT-1 affects TORC1/2 signaling and the unfolded protein response. PMID: 24999909
    3. Loss of PEPT-1 decreases intestinal proton influx leading to a higher uptake of free fatty acids with fat accumulation PMID: 19621081
    4. pep-2 cross-talks with both the C. elegans target of rapamycin (TOR) and the DAF-2/insulin-signaling pathways PMID: 15155758
  • 亞細胞定位：
    Apical cell membrane; Multi-pass membrane protein. Note=Colocalizes with nhx-2 along the apical membrane of the intestinal cells.
  • 蛋白家族：
    PTR2/POT transporter (TC 2.A.17) family
  • 組織特異性：
    Expressed specifically in the intestine.
  • 數據庫鏈接：

    KEGG: cel:CELE_K04E7.2

    STRING: 6239.K04E7.2.1

    UniGene: Cel.19638



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