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  4. Recombinant Neurospora crassa Frequency clock protein (frq), partial

Recombinant Neurospora crassa Frequency clock protein (frq), partial

  • 中文名稱：
    小神經孢子蟲frq重組蛋白
  • 貨號：
    CSB-YP321751NHA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小神經孢子蟲frq重組蛋白
  • 貨號：
    CSB-EP321751NHA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小神經孢子蟲frq重組蛋白
  • 貨號：
    CSB-EP321751NHA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小神經孢子蟲frq重組蛋白
  • 貨號：
    CSB-BP321751NHA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小神經孢子蟲frq重組蛋白
  • 貨號：
    CSB-MP321751NHA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    frq
  • Uniprot No.：
  • 別名：
    frq; B13D24.170; NCU02265Frequency clock protein
  • 種屬：
    Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Circadian clock component involved in the generation of biological rhythms, in particular in rhythm stability, period length, and temperature compensation. Oscillates in abundance with a daily peak early in the morning. Behaves as a negative element in circadian transcriptional loop. May bind to wc-2 protein. The complex frq-wc-2 may turn off the expression of frq.
  • 基因功能參考文獻：
    1. Altogether, our data indicate that the INO80 complex suppresses frq transcription by re-assembling the suppressive mechanisms at the frq promoter after transcription of frq. PMID: 28403234
    2. The affinity of CK1a for FRQ decreases with increasing FRQ phosphorylation, suggesting functional inactivation of FRQ in the negative feedback loop of the circadian clock before and independent of its degradation. PMID: 24710172
    3. This review focus is on the recent progress in understanding the molecular network governing the expression and activity of FRQ. [review] PMID: 25302868
    4. Data indicate the relationship of the light responsive elements of the frq promoter to its circadian feedback components. PMID: 24492881
    5. RCO-1 acts together with the histone modifier SET-2 and the chromatin remodeling factor CHD-1 to regulate normal chromatin structure at the frq locus, which permits rhythmic frq transcription. PMID: 24277852
    6. Data show that the Neurospora homologue of chd1 (NCU03060) is required for normal remodeling of chromatin at frq and is required for normal frq expression and sustained rhythmicity. PMID: 21811413
    7. the rhythmic FRQ phosphorylation profile observed is an important part of the negative feedback mechanism that drives robust circadian gene expression. PMID: 21300798
    8. prd-1 and prd-2 are good candidates for components of the FRQ-less oscillator and prd-3 and prd-4 act on the system mainly through effects on FRQ/WCC PMID: 20348458
    9. FRH has a role in regulating the phosphorylation and stability of Neurospora circadian clock protein FRQ PMID: 20159972
    10. Data suggest that the frequency-less oscillator is a slave oscillator to the transcription and translation feedback loops, which underlie circadian rhythm generation in Neurospora. PMID: 15677317
    11. Negative feedback in the circadian clock of Neurospora is mediated by FRQ PMID: 16051148
    12. Evolutionary comparisons with the Sordariaceae reveal significant conservation of the alternative splicing events, supporting their relevance to proper regulation of clock function. PMID: 16195340
    13. Phosphorylation of the Neurospora circadian clock protein FREQUENCY (FRQ) promotes its degradation through the ubiquitin-proteasome pathway PMID: 16246019
    14. stability of FRQ is an important factor in determining Neurospora's circadian period as well as the clock's temperature compensation PMID: 16314576
    15. Phosphorylation of FRQ at the PEST-2 region triggers its maturation from a nuclear repressor toward a cytoplasmic activator. PMID: 16421276
    16. FRQ protein stability is increased by lithium PMID: 16998153
    17. Results identify and quantify time-of-day-specific protein-protein interactions in the clock and show how these provide a platform for temporal and physical separation between the dual roles of FRQ. PMID: 19450533

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    FRQ family
  • 數據庫鏈接：

    KEGG: ncr:NCU02265



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