在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Murine coronavirus Spike glycoprotein (S), partial

  • 中文名稱:
    Recombinant Murine coronavirus Spike glycoprotein (S), partial
  • 貨號:
    CSB-EP318118MJY
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    S glycoprotein;E2;Peplomer protein
  • 種屬:
    Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    47.0 kDa
  • 表達區域:
    15-371aa
  • 氨基酸序列
    YIGDFRCIQLVNSNGANVSAPSISTETVEVSQGLGTYYVLDRVYLNATLLLTGYYPVDGSKFRNLALRGTNSVSLSWFQPPYLNQFNDGIFAKVQNLKTSTPSGATAYFPTIVIGSLFGYTSYTVVIEPYNGVIMASVCQYTICQLPYTDCKPNTNGNKLIGFWHTDVKPPICVLKRNFTLNVNADAFYFHFYQHGGTFYAYYADKPSATTFLFSVYIGDILTQYYVLPFICNPTAGSTFAPRYWVTPLVKRQYLFNFNQKGVITSAVDCASSYTSEIKCKTQSMLPSTGVYELSGYTVQPVGVVYRRVANLPACNIEEWLTARSVPSPLNWERKTFQNCNFNLSSLLRYVQAESLF
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Interacts with murine CEACAM1 to mediate viral entry.; mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.; Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
  • 基因功能參考文獻:
    1. structure of a mouse coronavirus S trimer ectodomain determined at 4.0 A resolution by single particle cryo-electron microscopy PMID: 26855426
    2. Authors demonstrate that murine hepatitis virus S proteins are indeed cleaved upon virus endocytosis, and identify a novel processing product S2* with characteristics of a fusion-active subunit. PMID: 24554652
    3. results indicate an important role for negatively charged endodomain residues in the incorporation of MHV S protein into assembled virions PMID: 23628137
    4. Biochemical and electron microscopic analyses revealed that virions, while assembled, contained little spike in the envelope, indicating that lack of infectivity during persistence was likely due to deficiency in spike incorporation. PMID: 21035161
    5. amino acid substitution in the receptor binding domain of the spike glycoprotein demonstrates ability of the virus to evolve to virulent phenotype PMID: 15919915
    6. observations suggest the amino-terminal region of the S protein, including the receptor-binding domain, & a region in the central part of the S protein containing HR1 & FP communicate & may interact physically in the higher-order structure of the spike PMID: 16956938
    7. This result suggests that the S2 substitutions exert powerful effects on the fusion trigger that normally passes from S1 to S2. PMID: 18032498

    顯示更多

    收起更多

  • 亞細胞定位:
    Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Betacoronaviruses spike protein family
  • 數據庫鏈接:

    KEGG: vg:1489752



主站蜘蛛池模板: 欧美3p两根一起进高清视频| 国产亚洲精品久久久久秋霞不卡| 亚洲旡码a∨一区二区三区| 亚洲男人的天堂www| 亚洲精品久久66国产高清| 国产v在线在线观看视频免费| 中文国产成人精品久久不卡| 伊人狠狠色丁香婷婷综合| 伊人精品成人久久综合| 成人亚洲欧美激情在线电影| 99热这里只有精品免费播放| 久久精品国产精品青草| 精品久久久久久777米琪桃花| 任我爽橹在线视频精品583| 中文字幕精品亚洲无线码二区| 亚洲欧美日韩中文无线码| 最新亚洲伦理中文字幕| 无码国产一区二区免费| 欧美日韩精品人妻狠狠躁免费视频| 亚洲人成精品久久久久桥| 欧美亚洲另类丝袜综合网| 国产肉体xxxx裸体784大胆| av怡红院一区二区三区| av无码国产在线观看岛国| 午夜爱爱爱爱爽爽爽网站| 亚洲精品欧美二区三区中文字幕| 国产精品香蕉在线的人| 免费人成网视频在线观看| 极品美女扒开粉嫩小泬图片| 天干天干天啪啪夜爽爽av| 777奇米四色成人影视色区| 国产自在自线午夜精品| 三个男吃我奶头一边一个视频 | 在线观看的网站| 免费国产高清毛不卡片基地| 亚洲综合在线一区二区三区| 亚洲精品喷潮一区二区三区| 色综合色欲色综合色综合色综合r| 国产内射在线激情一区| 8888四色奇米在线观看| 天天做天天爱天天综合网|