在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Acetylcholine receptor subunit alpha (Chrna1), partial

Recombinant Mouse Acetylcholine receptor subunit alpha (Chrna1), partial

In Stock
  • 中文名稱：
    Recombinant Mouse Acetylcholine receptor subunit alpha(Chrna1),partial
  • 貨號：
    CSB-YP005386MO
  • 規(guī)格：
    ￥2208
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    Chrna1; Acra; Acetylcholine receptor subunit alpha
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Extracellular Domain
  • 來源：
    Yeast
  • 分子量：
    26.5kDa
  • 蛋白標簽：
    N-terminal His-tagged/Tag-Free
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 基因功能參考文獻：
    1. A triad of residues aligning to Thr-152, Glu-209, and Lys-211 in Htr3, appear to be involved in side-chain interactions near binding sites in Htr3a (subunit alpha) and muscle-type Chrna1. Data suggest that mutating Htr3a triad to that of Chrna1 increases binding affinity of nicotine to Htr3a. (Htr3 = 5-hydroxytryptamine/serotonin receptor; Chrna1 = cholinergic receptor nicotinic alpha polypeptide 1) PMID: 29298898
    2. The results indicate that in the absence of the alpha1-nAChR subunit, clusters of nAChRs coupled to SK2 potassium channels as well as functional efferent synapses did form, showing that alpha1 is not necessary for these processes to take place. PMID: 27098031
    3. Findings suggest the possible role of controlling localised inflammatory response by parasympathetic cholinergic nerves through a1nAChRs of inflammation sites. PMID: 26778394
    4. This study demonstrates that genes coding for CHRNA1 subunits may contain variants associated with statin-induced ADRs. PMID: 22688219
    5. Chrna1 was co-purified with nicotinic acetylcholine receptor (AChR) in C2C12 myotubes. In addition, Stau1 was found to interact with Chrna1 mRNA, and knocking down of Stau1 by RNAi resulted in defective AChR clustering. PMID: 22884571
    6. These results suggest that in skeletal muscle cells, neural activity reduces the molar ratio of YB-1 relative to its binding AChR alpha mRNA, leading to an increase of ribosome binding to the mRNA, and thus activating translation. PMID: 21964286
    7. Chrna1 could be the first transcriptional target of atonal homolog 1 in the inner ear PMID: 17961150
    8. The nAChRalpha1 gene plays a significant role at the artery wall, and reducing its expression decreases aortic plaque development. PMID: 20810113
    9. These data identify caveolin-3 as a critical component of the signaling machinery that drives nicotinic acetylcholine receptor clustering and controls neuromuscular junction function. PMID: 19940021
    10. These two residues (and homologous sites in epsilon; subunit) are not involved in specific interactions with nicotinic agonist, and they affect activation of nicotinic receptor by shaping overall structure of agonist binding site. PMID: 12411516
    11. In murine muscle-type AChR alpha transmembrane 3 domain, tryptophan substitution at positions Phe-284, Ala-287, and Ile-290 produces a significant increase in normalized macroscopic response in channel gating, primarily the channel closing rate. PMID: 14705933
    12. the interaction between alpha AChR M1 and M2 domains plays a key role in channel gating PMID: 17028140
    13. Receptors with neutral side chains at position 89 function well, if side chain is less perturbing than amide of asparagine (nitro or keto groups allow function) or if a compensating backbone mutation is introduced to relieve unfavorable electrostatics. PMID: 17223685
    14. HDAC4 is a neural activity-regulated deacetylase and a key signaling component that relays neural activity to the muscle transcriptional machinery through Dach2, myogenin, and nAChR PMID: 17873280
    15. Data suggest that the alpha1 nicotinic acetylcholine receptor might play an important role in mechanotransduction of tensile stress loading on maxillofacial skeletal myocytes. PMID: 18163199
    16. In S269I, mutant the peak-current amplitude decreases along trains of nearly saturating ACh pulses delivered at physiologically relevant frequencies, consistent with enhanced entry into desensitization in congenital myasthenic syndrome. PMID: 19171769
    17. The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms. PMID: 19422391
    18. In this mouse experiemntal myasthenia gravis study demonstrated that Acetylcholine receptor-alpha1 subunit expression was increase with varying disease severity. PMID: 19609914
    19. fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis PMID: 19690163

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-1/CHRNA1 sub-subfamily
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： www片香蕉内射在线88av8| 亚洲 欧美 综合 另类 中字| 人妻无码视频一区二区三区 | 2019日韩中文字幕mv| 久久精品国产99国产精品亚洲| 熟妇人妻午夜寂寞影院| 欧美色欧美亚洲日韩在线播放| 国产精品久久自在自线不| 青青久在线视频免费观看| 国产互换人妻hd| 欧美性群另类交| 亚洲乱妇亚洲乱妇xinglu| 无码人妻av一区二区三区蜜臀| 亚洲日韩av无码一区二区三区人| 人妻丰满熟妇a无码区| 欧美性猛交xxxx乱大交| 国偷自产av一区二区三区| 国产精品亚洲а∨无码播放| 国产精品vr虚拟专区| 中文字幕人妻熟女人妻| 国产亚洲美女精品久久久| 老司机在线精品视频网站| 国产欧美日韩另类精彩视频| 欧美颜射内射中出口爆在线| 国产色视频自在线观看| 大又大粗又爽又黄少妇毛片免费 | 日韩人妻无码精品免费shipin| 一本色道久久综合亚州精品蜜桃| 国产成人啪精品午夜网站a片免费| 国产又黄又猛又粗又爽的a片动漫| 精品国产麻豆免费人成网站| 色又黄又爽18禁免费网站| √天堂8资源中文在线| 熟妇人妻无码中文字幕老熟妇| 女人高潮抽搐潮喷小视频| 日本一区午夜艳熟免费| 亚洲a成人片在线观看| 欧美又粗又大又黄的片| 国产精品视频免费一区二区| 欧美人做人爱a全程免费| 七七久久成人影院网站|