在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Chrna1 Antibody, HRP conjugated

  • 中文名稱:
    Chrna1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA005386LB01MO
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Mus musculus (Mouse) Chrna1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Chrna1 antibody; Acra antibody; Acetylcholine receptor subunit alpha antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Mouse
  • 免疫原:
    Recombinant Mouse Acetylcholine receptor subunit alpha protein (21-230AA)
  • 免疫原種屬:
    Mus musculus (Mouse)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 基因功能參考文獻:
    1. A triad of residues aligning to Thr-152, Glu-209, and Lys-211 in Htr3, appear to be involved in side-chain interactions near binding sites in Htr3a (subunit alpha) and muscle-type Chrna1. Data suggest that mutating Htr3a triad to that of Chrna1 increases binding affinity of nicotine to Htr3a. (Htr3 = 5-hydroxytryptamine/serotonin receptor; Chrna1 = cholinergic receptor nicotinic alpha polypeptide 1) PMID: 29298898
    2. The results indicate that in the absence of the alpha1-nAChR subunit, clusters of nAChRs coupled to SK2 potassium channels as well as functional efferent synapses did form, showing that alpha1 is not necessary for these processes to take place. PMID: 27098031
    3. Findings suggest the possible role of controlling localised inflammatory response by parasympathetic cholinergic nerves through a1nAChRs of inflammation sites. PMID: 26778394
    4. This study demonstrates that genes coding for CHRNA1 subunits may contain variants associated with statin-induced ADRs. PMID: 22688219
    5. Chrna1 was co-purified with nicotinic acetylcholine receptor (AChR) in C2C12 myotubes. In addition, Stau1 was found to interact with Chrna1 mRNA, and knocking down of Stau1 by RNAi resulted in defective AChR clustering. PMID: 22884571
    6. These results suggest that in skeletal muscle cells, neural activity reduces the molar ratio of YB-1 relative to its binding AChR alpha mRNA, leading to an increase of ribosome binding to the mRNA, and thus activating translation. PMID: 21964286
    7. Chrna1 could be the first transcriptional target of atonal homolog 1 in the inner ear PMID: 17961150
    8. The nAChRalpha1 gene plays a significant role at the artery wall, and reducing its expression decreases aortic plaque development. PMID: 20810113
    9. These data identify caveolin-3 as a critical component of the signaling machinery that drives nicotinic acetylcholine receptor clustering and controls neuromuscular junction function. PMID: 19940021
    10. These two residues (and homologous sites in epsilon; subunit) are not involved in specific interactions with nicotinic agonist, and they affect activation of nicotinic receptor by shaping overall structure of agonist binding site. PMID: 12411516
    11. In murine muscle-type AChR alpha transmembrane 3 domain, tryptophan substitution at positions Phe-284, Ala-287, and Ile-290 produces a significant increase in normalized macroscopic response in channel gating, primarily the channel closing rate. PMID: 14705933
    12. the interaction between alpha AChR M1 and M2 domains plays a key role in channel gating PMID: 17028140
    13. Receptors with neutral side chains at position 89 function well, if side chain is less perturbing than amide of asparagine (nitro or keto groups allow function) or if a compensating backbone mutation is introduced to relieve unfavorable electrostatics. PMID: 17223685
    14. HDAC4 is a neural activity-regulated deacetylase and a key signaling component that relays neural activity to the muscle transcriptional machinery through Dach2, myogenin, and nAChR PMID: 17873280
    15. Data suggest that the alpha1 nicotinic acetylcholine receptor might play an important role in mechanotransduction of tensile stress loading on maxillofacial skeletal myocytes. PMID: 18163199
    16. In S269I, mutant the peak-current amplitude decreases along trains of nearly saturating ACh pulses delivered at physiologically relevant frequencies, consistent with enhanced entry into desensitization in congenital myasthenic syndrome. PMID: 19171769
    17. The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms. PMID: 19422391
    18. In this mouse experiemntal myasthenia gravis study demonstrated that Acetylcholine receptor-alpha1 subunit expression was increase with varying disease severity. PMID: 19609914
    19. fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis PMID: 19690163

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-1/CHRNA1 sub-subfamily
  • 數據庫鏈接:


主站蜘蛛池模板: 国产成人艳妇aa视频在线| 中国丰满熟妇av| 亚洲欧美日韩综合俺去了| 精品国产青草久久久久福利| 成人欧美一区二区三区在线观看 | 午夜亚洲福利在线老司机| 国产肉体ⅹxxx137大胆| 欧洲美女黑人粗性暴交视频| 亚洲熟妇无码乱子av电影| 日本熟妇乱人伦xxxx| 中文字幕aav| 在线天堂最新版资源| 欧美成人一区二免费视频软件| 久久99精品久久久久久噜噜| 国产如狼似虎富婆找强壮黑人| 亚洲中字慕日产2020| 东京热人妻中文无码av| 最新成年女人毛片免费基地| 一边捏奶头一边啪高潮视频| 在线视频国产网址你懂的| 国产精品丝袜高跟鞋| 最近2019中文字幕大全第二页| 无码欧美黑人xxx一区二区三区 | 国内久久婷婷六月综合欲色啪| 国产av丝袜旗袍无码网站| 777精品出轨人妻国产| 中文av伊人av无码av狼人| 国产内射爽爽大片| 可以看三级的网站| 亚洲一区无码中文字幕| 欧美两根一起进3p在线观看| 无码人妻aⅴ一区二区三区69岛| 欧美激情一区二区三区高清视频| 国产精品高潮呻吟av久久小说| 日韩v亚洲v欧美v精品综合| 国产真人做爰毛片视频直播| 亚洲色大成网站www永久麻豆| 国产福利一区二区麻豆| 97久久精品人妻人人搡人人玩| 无码人妻丰满熟妇区毛片18 | 国产精品人妻一码二码|