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  4. Recombinant Mouse p53-induced protein with a death domain (Pidd), partial

Recombinant Mouse p53-induced protein with a death domain (Pidd), partial

  • 中文名稱：
    小鼠Pidd1重組蛋白
  • 貨號：
    CSB-YP863665MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Pidd1重組蛋白
  • 貨號：
    CSB-EP863665MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Pidd1重組蛋白
  • 貨號：
    CSB-EP863665MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Pidd1重組蛋白
  • 貨號：
    CSB-BP863665MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Pidd1重組蛋白
  • 貨號：
    CSB-MP863665MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Pidd1; Lrdd; Pidd; p53-induced death domain-containing protein 1; EC 3.4.21.-; Leucine-rich repeat and death domain-containing protein) [Cleaved into: PIDD-N; PIDD-C; PIDD-CC]
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis. Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis. Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B.
  • 基因功能參考文獻：
    1. NPM1-dependent nucleolar PIDDosome is a key initiator of the caspase-2 activation cascade. PMID: 28432080
    2. PIDD acts as a critical switcher between the NF-kappabeta transcription pathway and radiation-induced apoptosis PMID: 27643878
    3. The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd PMID: 25857265
    4. Loss of PIDD leads to an impaired inflammatory response after DNA damage. PMID: 23238565
    5. Caspase 2 activity can be induced in neurons from PIDD-null mice, and NGF deprivation or Abeta use caspase 2 and RAIDD to execute death of these neurons. PMID: 22515271
    6. P450 levels were higher in female DES-treated p53+/- mice compared to treated wild type mice. PMID: 11695552
    7. Results suggest that at least one alternative PIDDosome-independent mechanism of caspase-2 activation exists in mammals in response to DNA damage. PMID: 19364921
    8. PIDD does not play an essential role for all p53-mediated or p53-independent apoptotic pathways. PMID: 19575295

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：


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