在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse X-linked retinitis pigmentosa GTPase regulator (Rpgr), partial

Recombinant Mouse X-linked retinitis pigmentosa GTPase regulator (Rpgr), partial

  • 中文名稱：
    小鼠Rpgr重組蛋白
  • 貨號：
    CSB-YP865634MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Rpgr重組蛋白
  • 貨號：
    CSB-EP865634MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Rpgr重組蛋白
  • 貨號：
    CSB-EP865634MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Rpgr重組蛋白
  • 貨號：
    CSB-BP865634MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Rpgr重組蛋白
  • 貨號：
    CSB-MP865634MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Rpgr; X-linked retinitis pigmentosa GTPase regulator; mRpgr
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. May be involved in microtubule organization and regulation of transport in primary cilia. Plays an important role in photoreceptor integrity. Isoform 5 may play a critical role in spermatogenesis and in intraflagellar transport processes.
  • 基因功能參考文獻(xiàn)：
    1. In induced pluripotent stem cells and mouse knockouts that RPGR mediates actin dynamics in photoreceptors via the actin-severing protein, gelsolin. PMID: 28814713
    2. Together with a physical interaction between RPGR and the C-terminal domain of CEP290, our data suggest that RPGR and CEP290 genetically interact and highlight the involvement of hypomorphic alleles of genes as potential modifiers of heterogeneous retinal ciliopathies. PMID: 26936822
    3. We also correlated the features observed in patients with those of three Rpgr-mutant (Rpgr-ko, Rd9, and Rpgr-cko) mice. In patients, there was pronounced macular disease PMID: 27798110
    4. The discordant effect of the loss of RPGR on rod-dominant or cone-only rodent retinas is shown. PMID: 26908598
    5. study uncovers the pathogenic mechanism whereby absence of RPGR(ORF15) glutamylation leads to retinal pathology in patients with TTLL5 gene mutations and connects these two genes into a common disease pathway. PMID: 27162334
    6. Given a frequent occurrence of RPGR mutations in severe photoreceptor degeneration due to ciliary disorders, our results provide insights into pathways resulting in altered mature cilia function in ciliopathies. PMID: 26068394
    7. Data shsow that Rpgr ORF15 transcripts, but not protein, were detected in retinas from Rd9/Y male mice that exhibited retinal pathology. PMID: 22563472
    8. Misexpression of Rpgr(ex1-19) causes retinal degeneration that is considerably more severe than that caused by Rpgr knockout but photoreceptors tolerate overexpression of Rpgr(ORF15) without evidence of degeneration. PMID: 21546531
    9. RPGR localizes to the podocytes in the glomerulus as well as to primary cilia in parietal epithelium and tubules PMID: 20805823
    10. RPGR and RPGRIP isoforms are distributed and co-localized at restricted foci throughout the outer segments of human and bovine, but not mice rod photoreceptors. PMID: 12140192
    11. Certain truncated forms of RPGR can behave as a dominant, gain-of-function mutant. PMID: 14691151
    12. a CEP290/NPHP6 mutation perturbs its interaction with RPGR and results in early-onset retinal degeneration PMID: 16632484
    13. This complexity of defects in flagellar assembly suggests a role of RPGR in intraflagellar transport processes. PMID: 18579752

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium.; [Isoform 5]: Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
  • 組織特異性：
    Expressed in the retina (at protein level). Isoforms 1: Expressed in the retina (at protein level). Isoform 5: Expressed in the retina (at protein level). Expressed in the brain. Expressed in the testis (at protein level). Expressed in kidney (at protein
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 内射老妇bbwx0c0ck| 国产精品女丝袜白丝袜| 天美麻花果冻视频大全英文版| 国产特级毛片aaaaaa高清| a一区二区三区乱码在线 | 欧洲| 狠狠色综合7777久夜色撩人| 无码欧美黑人xxx一区二区三区 | 天堂av无码大芭蕉伊人av不卡| 亚洲日韩中文字幕久热| 精品国产一区二区三区四区| 亚洲精品第一国产综合野草社区| 午夜精品久久久内射近拍高清| 永久黄网站免费视频性色| 午夜人性色福利无码视频在线观看| 日韩吃奶摸下aa片免费观看| 艳妇乳肉豪妇荡乳av| 免费午夜无码片在线观看影院 | 老司机久久99久久精品播放免费| 国产精品真实灌醉女在线播放| 国产高清在线精品一区二区三区 | 偷拍区清纯另类丝袜美腿| 四虎一区二区成人免费影院网址| 国产在线拍揄自揄视频网试看| 国产拍揄自揄免费观看| 丰满人妻中伦妇伦精品app| 国产产区一二三产区区别在线| 色喜国模李晴超大尺度| 天堂网在线www资源| 亚洲区小说区图片区qvod| 极品尤物被啪到呻吟喷水| 小雪好紧好滑好湿好爽视频| 国产三级视频在线播放线观看 | 色婷婷综合久久久久中文一区二区 | 日韩欧美亚洲综合久久影院ds| 无码中文av波多野结衣一区| 欧美激情精品久久| 综合在线 亚洲 成人 欧美| 国产免费久久精品99reswag| 免费精品99久久国产综合精品| 欧美深性狂猛ⅹxxx深喉| 18禁美女黄网站色大片免费网站|