在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Uracil nucleotide/cysteinyl leukotriene receptor (Gpr17), partial

Recombinant Mouse Uracil nucleotide/cysteinyl leukotriene receptor (Gpr17), partial

  • 中文名稱：
    小鼠Gpr17重組蛋白
  • 貨號：
    CSB-YP764656MO1
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Gpr17重組蛋白
  • 貨號：
    CSB-EP764656MO1
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Gpr17重組蛋白
  • 貨號：
    CSB-EP764656MO1-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Gpr17重組蛋白
  • 貨號：
    CSB-BP764656MO1
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Gpr17重組蛋白
  • 貨號：
    CSB-MP764656MO1
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Gpr17; Uracil nucleotide/cysteinyl leukotriene receptor; UDP/CysLT receptor; G-protein coupled receptor 17
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
  • 基因功能參考文獻(xiàn)：
    1. Study defined the differentiation capabilities of GPR17+ cells in rodents after myelin disruption in two different models, the former characterized by diffused immune response against myelin components and strong inflammation (the EAE model), and the latter one consisting in local demyelination induced by a toxic agent (the cuprizone model). PMID: 29424466
    2. Transcription factor FoxO1 regulates glucose metabolism and feeding through the expression of Gpr17 in hypothalamic AgRP neurons. PMID: 22682251
    3. Conditional knockout of Gpr17 in hypothalamic AgRP neurons improves glucose metabolism and energy homeostasis by increasing central sensitivity to insulin and leptin. PMID: 26180086
    4. G protein-coupled receptor, Gpr17, was identified as the target of transcription factor FoxO1 to mediate its function in feeding regulation in hypothalamic AgRP neurons, suggesting it is a new drug target for metabolic disorders via actions on appetite control. PMID: 22682251
    5. The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke. PMID: 28594400
    6. The loss of Gpr17 in mice led to precocious myelination and an earlier onset of remyelination after demyelination PMID: 27733608
    7. uracil nucleotides and cysteinyl leukotrienes do not activate human, mouse, or rat GPR17 in various cellular backgrounds. PMID: 28254957
    8. GPR17(+) cells--in contrast to GPR17(-) NG2-glia--did not differentiate within 3 months, a peculiarity that was overcome after cerebral damage induced by acute injury or ischemia PMID: 26464068
    9. stimulation of GPR17 by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein expression levels mainly by triggering the Galphai/o signaling pathway. PMID: 26620557
    10. Agrp-Gpr17(-/-) mice show reduced food intake, increased relative energy expenditure, and increased satiety, resulting in leanness and reduced body fat. They also show increased central nervous system sensitivity to insulin and leptin. PMID: 26180086
    11. The mouse GPR17 receptor plays a central role in the early response of cardiac stromal cells to ischaemia. PMID: 24909956
    12. Data indicate that small molecule MDL29,951 activates human, mouse and rat orphan G protein-coupled receptor GPR17. PMID: 24150254
    13. GPR17 is a marker for progenitor progression within the oligodendroglial lineage that participates in postacute reactivity of NG2-proteoglycan expressing cells in different injury paradigms. PMID: 21956849
    14. analysis of agonist-induced trafficking of native GPR17 in oligodendroglial cells PMID: 23288840
    15. Study finds that transcription factor FoxO1 exerts integrative control of leptin, insulin, and amino acid signaling in AgRP neurons, effectively coordinating food intake with peripheral metabolism; and identifies of a heretofore unrecognized FoxO1 pathway that regulates food intake through the G protein-coupled receptor, Gpr17. PMID: 22682251
    16. GPR17 is expressed by a subpopulation of oligodendrocyte precursor cells, but not by astrocytes; this expression pattern is also confirmed in vivo. In vitro, GPR17 expression is markedly influenced by culturing conditions. PMID: 21264945
    17. GPR17 negatively regulates type 1 cysteinyl leukotriene receptor (CysLT1R)-mediated inflammatory cell accumulation in the bronchoalveolar lavage fluid and lung, in both the antigen presentation and downstream phases of allergic pulmonary inflammation. PMID: 20574000
    18. GPR17 orchestrates the transition between immature and myelinating oligodendrocytes via an ID protein-mediated negative regulation and may serve as a potential therapeutic target for CNS myelin repair. PMID: 19838178
    19. GPR17 may act as a "sensor" that is activated upon brain injury on several embryonically distinct cell types, and may play a key role in both inducing neuronal death inside the ischemic core and in orchestrating the local remodeling/repair response. PMID: 18974869
    20. GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. PMID: 19561298

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 国产精品成人一区二区不卡| 未满小14洗澡无码视频网站| 一区二区三区无码被窝影院| 女人的精水喷出来视频| 亚洲精品国产综合麻豆久久99 | 亚洲一区av在线观看| 欧美xxxx做受欧美1314| 亚洲国产欧美在线成人app| 亚洲欧美日韩综合俺去了 | 欧洲熟妇色xxxx欧美老妇多毛网站 | 欲香欲色天天综合久久| 久久麻豆成人精品av| 国产av一区二区三区传媒| 四虎国产精品亚洲一区久久特色| 亚洲国产精品久久精品成人网站| 人妻少妇精品一区二区三区| 国产精品99久久免费黑人人妻| 国内精品美女视频免费直播| 高潮好爽视频在线观看| 人人爽天天碰天天躁夜夜躁| 日韩精品毛片无码一区到三区 | 亚洲一区二区无码影院| 最新日韩精品中文字幕| 亚洲欧美另类久久久精品| 欧美网站免费观看在线| 亚洲a∨精品无码一区二区| 亚洲一区二区三区| 朝鲜女人大白屁股ass| 无码中文字幕av免费放| 亚洲欧美日韩中文在线制服| 使劲快高潮了国语对白在线| 玩弄放荡人妇系列av在线网站| 好男人在在线社区www在线影院| 欧美 日韩 国产 成人 在线观看| 乱色欧美激惰| 日韩精品无码免费专区午夜不卡| 国产在线乱子伦一区二区| 日本va欧美va精品发布| 久久国内精品自在自线| 国产明星xxxx色视频| 性视频播放免费视频|