在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase 10 (Usp10)

Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase 10 (Usp10)

  • 中文名稱：
    小鼠Usp10重組蛋白
  • 貨號：
    CSB-YP025696MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Usp10重組蛋白
  • 貨號：
    CSB-EP025696MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Usp10重組蛋白
  • 貨號：
    CSB-EP025696MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Usp10重組蛋白
  • 貨號：
    CSB-BP025696MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Usp10重組蛋白
  • 貨號：
    CSB-MP025696MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Usp10; Kiaa0190; Ode-1; UchrpUbiquitin carboxyl-terminal hydrolase 10; EC 3.4.19.12; Deubiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    -
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Deubiquitinates TBX21 leading to its stabilization.
  • 基因功能參考文獻：
    1. Deubiquitylase USP10 interacts with RNF168 and TOP2alpha, and restrains ubiquitylation of TOP2alpha as well as its chromatin binding. PMID: 27558965
    2. USP10 directly interacted with and stabilized PTEN via deubiquitination. PMID: 28852924
    3. USP10 is an essential deubiquitinase in hematopoiesis and functions by inhibiting apoptosis of hematopoietic stem cells including long-term HSCs. PMID: 27974222
    4. Data demonstrated that AMPK-USP10 form a positive feedforward loop that ensures amplification of AMPK activation in response to fluctuation of cellular energy status. PMID: 26876938
    5. vasopressin-induced Usp10 deubiquitylates and stabilizes endogenous SNX3 and consequently promotes cell surface expression of ENaC in kidney PMID: 18632802

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Early endosome.
  • 蛋白家族：
    Peptidase C19 family, USP10 subfamily
  • 數據庫鏈接：


主站蜘蛛池模板： 免费看又黄又无码的网站| 亚洲五月综合缴情在线观看| 精产国品一二三产区9977 | 国产av精国产传媒| 亚洲国产欧美国产综合久久| 人成午夜免费大片| 久久免费看少妇高潮v片特黄| 日本免费一区二区三区最新| 大肉大捧一进一出视频出来呀| 亚洲精品av一区在线观看| 人妻av无码一区二区三区| 永久免费无码网站在线观看| 久久精品国产99国产精品导航| 国产精品一区二区久久乐下载| 国自产拍偷拍精品啪啪av| 真实的国产乱xxxx| 潮喷失禁大喷水无码| 亚洲欲色欲色xxxxx在线观看| 亚洲色成人影院在线观看| 一日本道a高清免费播放| 国产69精品久久久久人妻刘玥| 一本色道久久综合亚州精品蜜桃| 日本免费高清一本视频| av免费不卡国产观看| 欧美激欧美啪啪片免费看| 欧美影视精品久久| 久久综合给合久久97色| 成人无码免费一区二区三区| 琪琪电影午夜理论片八戒八戒| 无码精品日韩专区| 欧美人与牲动交xxxx| 激情内射人妻1区2区3区| 又粗又猛又黄又爽无遮挡| 一区二区三区av高清免费波多 | 欧美在线观看免费专区| 国产xxx69麻豆国语对白| 最新国产精品自在线观看| 激情无码人妻又粗又大中国人| 欧美丰满熟妇xxxx性ppx人交| 日本精品久久久久中文字幕| 成 人 网 站94免费观看|