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  4. Recombinant Mouse Transcription factor A, mitochondrial (Tfam)

Recombinant Mouse Transcription factor A, mitochondrial (Tfam)

In Stock
  • 中文名稱：
    小鼠Tfam重組蛋白
  • 貨號：
    CSB-EP023413MO
  • 規格：
    ￥2328
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    (mtTFA)(Testis-specific high mobility group protein)(TS-HMG)
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.coli
  • 分子量：
    30.9 kDa
  • 表達區域：
    43-243aa
  • 氨基酸序列
    SSMGSYPKKPMSSYLRFSTEQLPKFKAKHPDAKLSELVRKIAALWRELPEAEKKVYEADFKAEWKAYKEAVSKYKEQLTPSQLMGMEKEARQRRLKKKALVKRRELILLGKPKRPRSAYNIYVSESFQEAKDDSAQGKLKLVNEAWKNLSPEEKQAYIQLAKDDRIRYDNEMKSWEEQMAEVGRSDLIRRSVKRSGDISEH
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.; May also function as a transcriptional activator or may have a structural role in the compaction of nuclear DNA during spermatogenesis.
  • 基因功能參考文獻：
    1. TFAM overexpression normalizes pathological hypertrophic factor NFAT4 in the presence of oxidative stress. PMID: 28800400
    2. results suggest a nucleation-cooperativity-based mechanism for sensitive detection of mitochondrial DNA and pathogen genomes, and identify HMGB/TFAM proteins as DNA-structuring host factors; they provide an explanation for the peculiar cGAS dimer structure and suggest that cGAS preferentially binds incomplete nucleoid-like structures or bent DNA PMID: 28902841
    3. TFAM is essential for transcription, replication and packaging of mtDNA into nucleoids. Tfam knockout mice display embryonic lethality secondary to severe mtDNA depletion. In this report, for the first time, we associate a homozygous variant in TFAM with a novel mtDNA depletion syndrome. PMID: 27448789
    4. Perturbation of mitochondrial complex function by ablation of the mitochondrial transcription factor A (Tfam) reproduces multiple hallmarks of aging in hippocampal neurogenesis. PMID: 28111078
    5. During muscle differentiation, Tfam protein levels are regulated by the availability of Tfam mRNA, which is controlled by both transcription and mRNA stability. PMID: 26182383
    6. TFAM binds to RNA-containing 4-way junctions but does not bind appreciably to RNA hairpins, internal loops, or linear RNA:DNA hybrids. PMID: 26545237
    7. Data show that mitochondrial transcription factor A (TFAM) packages single mitochondrial DNA (mtDNA) molecules. PMID: 26305956
    8. There was upregulation of mtDNA and TFAM in 6-wk diabetic mice, suggesting that TFAM activation could be a therapeutic strategy to treat peripheral neuropathy. PMID: 25944881
    9. This study demonistrated that Tfam gene inactive patkinsin disease cause dopamine loss and circadian rhythm disorder. PMID: 25171792
    10. Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFalpha release via RAGE- and TLR9-responsive plasmacytoid dendritic cells. PMID: 23951313
    11. overexpression of TFAM can restore mitochondrial function to normal levels in NYGGF4-overexpressing adipocytes PMID: 23274913
    12. Acute exercise induces tumour suppressor protein p53 translocation to the mitochondria and promotes a p53-Tfam-mitochondrial DNA complex in skeletal muscle. PMID: 23690562
    13. Data indicate that TFAM-deficient keratinocytes failed to generate mitochondria-derived reactive oxygen species, and prevented the transmission of Notch and beta-catenin signals for epidermal differentiation and hair follicle development. PMID: 23386745
    14. The reduction of mitochondrial transcription factor A (TFAM) in adipose tissue increases mitochondria oxidation capacity due to complex I deficiency and greater uncoupling. PMID: 23168219
    15. Data suggest that microRNA 494 regulates mitochondrial biogenesis by down-regulating mtTFA (mitochondrial transcription factor A) and Foxj3 (forkhead box J3 protein) during myocyte differentiation and skeletal muscle adaptation to physical exercise. PMID: 23047984
    16. disruption of mitochondrial function by selective deletion of the Tfam gene in midbrain DA neurons results in physiological changes in the nigrostriatal circuitry that occur before the onset of locomotor impairments of Parkinson disease. PMID: 21233488
    17. TFAM overexpression can reduce mitochondrial permeability transition and ameliorate delayed neuronal death in the hippocampus after transient forebrain ischemia PMID: 20102525
    18. The MitoPark mouse, in which the mitochondrial transcription factor Tfam is selectively removed in midbrain dopamine (DA) neurons, is a genetic model for Parkinson's disease and response to levodopa. PMID: 20002202
    19. TFAM induces a structural change of the promoter that is required for POLRMT-dependent promoter recognition PMID: 15526033
    20. Accumulation of TFAM protein after H2O2 stress contributes to the regeneration of the mtDNA pool but that other mechanisms, independent from the TFAM protein amount have to be postulated to explain the proliferation of the mtDNA pool after GSH depletion. PMID: 16439064
    21. These results indicate that TFAM alone is sufficient to organize mitochondrial chromatin and provide a mechanism for nucleoid formation. PMID: 17581862

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  • 亞細胞定位：
    [Isoform Mitochondrial]: Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.; [Isoform Nuclear]: Nucleus.
  • 組織特異性：
    The mitochondrial isoform is widely expressed while the nuclear isoform is testis-specific.
  • 數據庫鏈接：


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