在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Toll-interacting protein (Tollip)

Recombinant Mouse Toll-interacting protein (Tollip)

  • 中文名稱：
    小鼠Tollip重組蛋白
  • 貨號(hào)：
    CSB-YP886395MO
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Tollip重組蛋白
  • 貨號(hào)：
    CSB-EP886395MO
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Tollip重組蛋白
  • 貨號(hào)：
    CSB-EP886395MO-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Tollip重組蛋白
  • 貨號(hào)：
    CSB-BP886395MO
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Tollip重組蛋白
  • 貨號(hào)：
    CSB-MP886395MO
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Tollip; Toll-interacting protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    2-274
  • 氨基酸序列
    ATTVSTQRG PVYIGELPQD FLRITPTQQQ QQIQLDAQAA QQLQYGGTVG TVGRLSITVV QAKLAKNYGM TRMDPYCRLR LGYAVYETPT AHNGAKNPRW NKVIQCTVPP GVDSFYLEIF DERAFSMDDR IAWTHITIPE SLKQGQVEDE WYSLSGRQGD DKEGMINLVM SYTSLPAAMM MPPQPVVLMP TVYQQGVGYV PIAGMPAVCS PGMVPMAMPP PAVAPQPRCN EEDLKAIQDM FPNMDREVIR SVLEAQRGNK DAAINSLLQM GEES
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates.
  • 基因功能參考文獻(xiàn)：
    1. Tollip-deficiency may accelerate neuron death related to neurological disease such as Alzheimer's disease PMID: 27720815
    2. Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression PMID: 28954885
    3. Tollip deficiency selectively leads to enlarged yet stable atherosclerotic plaques, increased circulating lipids, liver steatosis, and reduced inflammation. Compromised lipophagy and reduced expression of inflammatory mediators due to Tollip deficiency may be the underlying causes. PMID: 28396568
    4. This study demonstrated that a critical role of Tollip in the early phase of TLR4-mediated neuroinflammation. PMID: 27927222
    5. Tollip acts as a novel modulator of I/R injury by promoting neuronal apoptosis and ischaemic inflammation, which are largely mediated by suppression of Akt signalling. PMID: 26011492
    6. TOLLIP contributes to mortality following myocardial infarction through promoting inflammation and apoptosis PMID: 25765712
    7. Data show that histone lysine methyltransferase Ezh1 promotes toll-like receptor (TLR)-triggered inflammatory cytokine production by suppressing the Toll-interacting protein (Tollip), contributing to full activation of the innate immunity. PMID: 25687760
    8. Overall, our data show an essential role for Tollip on colitis susceptibility in mice. PMID: 24572204
    9. negative regulator of pathological cardiac hypertrophy by blocking the AKT signalling pathway PMID: 24285748
    10. Tollip cooperates with Smad7 to modulate intracellular trafficking and degradation of ubiquitinated TbetaRI, whereby negatively regulates TGF-beta signaling pathway. PMID: 23027871
    11. DNA and protein coimmunization induces regulatory dendritic cells through caveolin-1- and Tollip-mediated negative signaling. PMID: 22904311
    12. Low-dose lipopolysaccharide utilizes Tollip and interleukin (IL)-1 receptor-associated kinase (IRAK)-1 to induce mitochondrial reactive oxygen species to subsequently induce activating transcription factor (ATF)2 in chronic low-grade inflammatory disease. PMID: 22706082
    13. Tollip is a critical mediator responsible for the anti-inflammatory action of epigallocatechin-3-gallate in activated macrophages. PMID: 20511545
    14. Tollip controls the magnitude of inflammatory cytokine production in response to IL-1beta and LPS. PMID: 16428431

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Tollip family
  • 組織特異性：
    Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney, thymus, pancreas and testis.
  • 數(shù)據(jù)庫(kù)鏈接：


主站蜘蛛池模板： 成人网站免费观看| 无码少妇精品一区二区免费动态| 亚洲国产欧美在线成人| 97影院理论片手机在线观看| 亚洲色无码国产精品网站可下载| 久久国产乱子伦精品免费女人| 国产无遮挡又黄又爽奶头| 亚洲成l人在线观看线路| 国产欧美va欧美va香蕉在线| 久久av一区二区三区| 亚洲18色成人网站www| 国产a国产片国产| 亚洲成a人v在线蜜臀| 日本xxxx18野外无毒不卡| av人摸人人人澡人人超碰妓女| 国产欧美日韩综合精品二区| 日韩精品无码一区二区中文字幕| 久久国产热精品波多野结衣av| 四虎永久在线精品免费无码| 巨乳美乳一区二区三区| 成熟妇人a片免费看网站| 人妻熟妇乱又伦精品视频中文字幕 | 男女啪啪免费观看的网址| 麻豆精品偷拍人妻在线网址| 亚洲欧美日韩在线一区| 亚洲色婷婷久久精品av蜜桃久久 | 24小时日本在线www免费的| 亚洲色无码专区一区| 蜜臀avwww国产天堂| 国产偷国产偷亚洲高清日韩| 囯产精品一品二区三区| 成 人 黄 色 大片| 亚洲人成网站18禁止中文字幕| 亚洲成a∨人片在线观看不卡 | 西西人体www大胆高清视频| av无码一区二区大桥久未| 人人爽天天碰狠狠添| 国产精品99久久久久久久女警| 色多多性虎精品无码av| 日韩新无码精品毛片| 2018高清国产一区二区三区|