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  4. Recombinant Mouse Sulfiredoxin-1 (Srxn1)

Recombinant Mouse Sulfiredoxin-1 (Srxn1)

  • 中文名稱：
    小鼠Srxn1重組蛋白
  • 貨號：
    CSB-YP872019MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Srxn1重組蛋白
  • 貨號：
    CSB-EP872019MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Srxn1重組蛋白
  • 貨號：
    CSB-EP872019MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Srxn1重組蛋白
  • 貨號：
    CSB-BP872019MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Srxn1重組蛋白
  • 貨號：
    CSB-MP872019MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Srxn1; Npn3; Srx; Sulfiredoxin-1; EC 1.8.98.2; Neoplastic progression protein 3
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-136
  • 氨基酸序列
    MGLRAGGALR RAGAGPGAPE GQGPGGAQGG SIHSGCIATV HNVPIAVLIR PLPSVLDPAK VQSLVDTILA DPDSVPPIDV LWIKGAQGGD YYYSFGGCHR YAAYQQLQRE TIPAKLVRST LSDLRMYLGA STPDLQ
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.
  • 基因功能參考文獻：
    1. sulfiredoxin is degraded by Lon in a manner dependent on PrxIII hyperoxidation state. PMID: 26236015
    2. Srx is one of the critical components that contribute to mouse skin tumorigenesis in vivo. PMID: 24503444
    3. data provide in vivo evidence that loss of Srx renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis, suggesting that Srx has a critical oncogenic role in cancer development PMID: 23393226
    4. The concerted action of PrxIII and Srx is important for protection against pyrazole-induced oxidative stress arising from the convergent induction of CYP2E1-derived and ER stress-derived ROS in mitochondria. PMID: 22490042
    5. Srx functions as a novel component to maintain the balance between H2O2 production and elimination PMID: 22086924
    6. NO-mediated Srx up-regulation is mediated by the transcription factor nuclear factor erythroid 2-related factor (Nrf2) and the NO/Srx pathway inhibits generation of reactive oxygen species. PMID: 21466852
    7. Sulfiredoxin protects mice from lipopolysaccharide-induced endotoxic shock PMID: 21083423
    8. LPS-mediated Srx induction is dependent on both AP-1 and Nrf2, which is regulated by Nox2-derived reactive oxygen species. PMID: 20826812
    9. Synaptic activity upregulated the thioredoxin-peroxiredoxin reactivating gene sulfiredoxin. PMID: 18344994

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Sulfiredoxin family
  • 數據庫鏈接：


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