在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Stromal interaction molecule 2 (Stim2), partial

Recombinant Mouse Stromal interaction molecule 2 (Stim2), partial

  • 中文名稱：
    小鼠Stim2重組蛋白
  • 貨號：
    CSB-YP022830MO1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Stim2重組蛋白
  • 貨號：
    CSB-EP022830MO1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Stim2重組蛋白
  • 貨號：
    CSB-EP022830MO1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Stim2重組蛋白
  • 貨號：
    CSB-BP022830MO1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Stim2重組蛋白
  • 貨號：
    CSB-MP022830MO1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Stim2; Kiaa1482; Stromal interaction molecule 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.
  • 基因功能參考文獻：
    1. Stim1 and Stim2 deficient B cells show an accelerated pace of affinity maturation but do not have dramatically impaired antibody production to T-independent antigen immunization PMID: 27572320
    2. We found that STIM2 is required for the stable expression of both LTP and LTD at CA3-CA1 hippocampal synapses. Altered plasticity in Stim2 cKO mice is associated with subtle alterations in the shape and density of dendritic spines in CA1 neurons. PMID: 27544849
    3. neutrophil cytokine production required STIM2, but not STIM1, at least in part as a result of redox regulation of cytokine gene expression PMID: 28724541
    4. Expression of STIM2 protein rescued CaMKII activity and protected mushroom spines from Abeta42 oligomer toxicity in vitro and in vivo. PMID: 26275606
    5. The data from this study indicate that upregulation of STIM2 and Orai2 is involved in the phenotypic transition of pulmonary arterial smooth muscle cells from a contractile state to a proliferative state. PMID: 25673771
    6. Stim2 plays a moderate role in the development of autoinmune responses in a murine model of EAE, stimulating the proliferation of lymphocytes and the production of IFN-gamma/IL-17 by neuroantigen-specific T cells. PMID: 20028655
    7. Using mice lacking STIM1 and its homologue STIM2, authors find that store-operated calcium entry in CD8(+) T cells is required to prevent the engraftment of melanoma and colon carcinoma cells and to control tumour growth. PMID: 23922331
    8. STIM1 and STIM2-mediated store-operated Ca2+ influx, leading to efficient activation of NFAT (nuclear factor of activated T cells), is critical for the postselection maturation of agonist-selected T cells. PMID: 23499491
    9. STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome. PMID: 22904194
    10. show that endoplasmic reticulum calcium sensors STIM1- and STIM2-induced store-operated Ca(2+) influx is critical for B cell regulatory function PMID: 21530328
    11. Absence of STIM2 in mouse embryonic fibroblasts results in a decreased store-operated calcium ion entry, although this inhibition is less pronounced than for STIM1. PMID: 20801505
    12. both STIM1 and STIM2 are critical for T-cell function and autoimmunity in vivo. PMID: 21061435
    13. STIM2 deficiency significantly delays onset and attenuates the clinical course of experimental allergic encephalitis. PMID: 20028655
    14. Promote store-operated entry of calcium ions into T cells; required for the development and function of regulatory T cells. PMID: 18327260
    15. Data demonstrate that cellular levels of STIM1 and STIM2, which are key players in capacitative Ca2+ entry, depend on presenilins. PMID: 19111578
    16. show that STIM2, but not STIM1, is essential for capacitive Ca(2+) entry and ischemia-induced cytosolic Ca(2+) accumulation in neurons. PMID: 19843959

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲 欧洲 日韩 综合色天使| 国产成人综合久久精品| 国产97色在线 | 欧洲| 99在线在线视频观看| 精品久久久久久人妻无码中文字幕| 鲁一鲁一鲁一鲁一澡| 猫咪www免费人成网站无码| 最新69国产成人精品视频| 欧美日韩精品一区二区在线视频| 丰满妇女强制高潮18xxxx| 92国产精品午夜福利| 在线天堂www在线国语对白| 免费无码又爽又刺激软件下载| 亚洲乱码中文字幕小综合| 亚洲国产成人久久综合| 私人毛片免费高清影视院| 无码人妻久久一区二区三区不卡| 久久综合九色综合欧美就去吻| 免费永久在线观看黄网站| 闺蜜张开腿让我爽了一夜| 国产精品99精品无码视亚| 亚洲国产精品久久网午夜| 亚洲a∨国产av综合av网站| 欧美日韩亚洲国产综合乱| 欧美无人区码suv| 国产对白老熟女正在播放| 精品无码一区二区三区电影| 狠狠色噜噜狠狠狠8888在| 大尺度无遮挡激烈床震网站| 婷婷色婷婷开心五月四房播播 | 久久久亚洲欧洲日产国码αv| 秋霞无码久久久精品交换| 亚洲欧美日韩一区在线观看| 欧美老熟妇牲交| 欧美亚洲日韩国产网站| 中文字幕精品视频在线看免费| 欧美精品色婷婷五月综合 | 毛片免费全部播放无码| 波多野结衣一区二区三区高清| 亚洲人成网站在线无码| 久久精品中文字幕有码|