在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Sprouty-related, EVH1 domain-containing protein 1 (Spred1)

Recombinant Mouse Sprouty-related, EVH1 domain-containing protein 1 (Spred1)

In Stock
  • 中文名稱：
    Recombinant Mouse Sprouty-related, EVH1 domain-containing protein 1 (Spred1)
  • 貨號(hào)：
    CSB-EP835669MO
  • 規(guī)格：
    ￥1344
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    Spred1
  • Uniprot No.：
  • 別名：
    Spred-1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.coli
  • 分子量：
    55.6 kDa
  • 表達(dá)區(qū)域：
    2-444aa
  • 氨基酸序列
    SEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTVFRVPHQEENGCADFFIRGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAIEDISLGCPASKTEAEGGDDDLQTTEEDTSRSLVKDHFFQQETVVTSEPYRSSDIRPLPFEDLNARRVYLQSQVSQIPFSQQGLDIQSRSMEYVQRQISKECGSLKSQTRVPLKSIRHVSFQDEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDTDSSVPFSKQDSKKSDYLYHCGDETKLSSLKDSVVFKTQPPSLKFKSKRRKEDGERSRCVYCQERFNHEENARGKCQDAPDPVKRCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWLALVALSFIVPCMCCYVPLRMCHRCGEACGCCGGKHKAAG
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells.
  • 基因功能參考文獻(xiàn)：
    1. Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer PMID: 26075267
    2. SPREDs promote self-renewal and inhibit mesodermal differentiation of murine ES cells by selective suppression of the ERK/MAPK signaling pathway in pluripotent cells PMID: 25690936
    3. The data suggest that Spred1 negatively regulates group 2 innate lymphoid cell development and functions through the suppression of the Ras-ERK pathway. PMID: 26116510
    4. Microrna-126 was transported into recipient human coronary artery endothelial cells by endothelial microparticles and functionally regulated the target protein sprouty-related, EVH1 domain-containing protein 1 (SPRED1). PMID: 24014835
    5. show that neurofibromin, the NF1 gene product, is a Spred1-interacting protein that is necessary for Spred1's inhibitory function PMID: 22751498
    6. The results suggest that Spred1 negatively regulates mast cell activation, which is modulated by miR126. PMID: 21668589
    7. SPRED1 is a likely substrate of SHP2, whose tyrosine dephosphorylation is required to attenuate the inhibitory action of SPRED1 in the Ras/ERK pathway. PMID: 21531714
    8. Data show that both SPRED1 and SPRED2 inhibit the ability of DYRK1A to phosphorylate its substrates. PMID: 20736167
    9. These data suggest that Spreds are key regulators of RhoA-mediated cell motility and signal transduction. Furthermore, our study suggests that the induction of Spreds could be a novel strategy for preventing cancer cell metastasis. PMID: 15184877
    10. role in hematopoiesis PMID: 15465815
    11. Spred-1 and Spred-2 were found to be expressed predominantly in brain PMID: 15580519
    12. Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness by modulating IL-5 signaling in allergic asthma, without affecting helper T cell differentiation PMID: 15630138
    13. We show here that Spred-1 and Spred-2 appear to have distinct mechanisms whereby they induce their effects, as the Sprouty domain of Spred-1 is not required to block MAPK (mitogen-activated protein kinase) activation, while that of Spred-2 is required. PMID: 15683364
    14. These data suggest that Spred-1 inhibits ERK activation in collaboration with Cav-1 PMID: 16115197
    15. Spred1 is essential for embryonic lymphangiogenesis by regulating VEGFR3 signaling. PMID: 17438136
    16. Spred1 is required for synaptic plasticity and hippocampus-dependent learning. PMID: 19118178
    17. TGF-beta mediates an inhibitory mechanism on CD8+ TILs involving TCR-signaling blockade and the upregulation of Spred-1. PMID: 19319531
    18. Spred1 is critical for normal cortical development, as it modulates progenitor self-renewal/proliferation and helps maintain the integrity and organization of germinal zones PMID: 20047999

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Nucleus.
  • 組織特異性：
    Expressed in brain. Weakly expressed in lung, heart, liver, kidney, intestine, spleen, testis, thymus, colon and ovary. Also expressed in embryonic tissues such as heart, lung, liver and brain. Highly expressed in IL3-dependent hematopoietic cell lines (B
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 国产乱人伦精品免费| 国产高清视频在线观看97| 97国产揄拍国产精品人妻| 亚洲熟妇av综合网五月| 野花社区在线观看视频| 国产精品国产免费无码专区不卡| 亚洲中文字幕永久在线不卡| 国产精华av午夜在线观看| 中文字幕乱码免费| 99精品国产在热久久婷婷| 亚洲综合色在线视频www| 裸体女人高潮毛片| 国产久久精品| 人妻熟女一区二区aⅴ林晓雪| 久久国产avjust麻豆| 精品国产国语对白久久免费 | 俄罗斯大荫蒂女人毛茸茸| 亚洲欧美日韩愉拍自拍美利坚| 国产成人午夜在线视频a站| а√在线中文网新版地址在线 | 日本亚洲欧美在线视观看| 国产色情又大又粗又黄的电影| 色悠久久久久久久综合网| 亚洲日本中文字幕天天更新| 午夜福利18以下勿进免费| 很黄很色60分钟在线观看| 吃奶呻吟打开双腿做受动态图| 欧美日韩精品一区二区视频| 久久爱www人成狠狠爱综合网| av片在线观看永久免费| 精品无码无人网站免费视频| 亚洲综合色区无码专区| 精品亚洲成av人在线观看| 亚洲精品欧美二区三区中文字幕| 亚洲熟妇色xxxxx欧美老妇| 婷婷色香五月综合缴缴情| 国产精品午夜爆乳美女视频| 成人片黄网站a毛片免费| 免费精品99久久国产综合精品| 国产综合久久久久| 天堂最新版资源网|