在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Solute carrier family 22 member 1 (Slc22a1), partial

Recombinant Mouse Solute carrier family 22 member 1 (Slc22a1), partial

  • 中文名稱：
    小鼠Slc22a1重組蛋白
  • 貨號：
    CSB-YP021442MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Slc22a1重組蛋白
  • 貨號：
    CSB-EP021442MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Slc22a1重組蛋白
  • 貨號：
    CSB-EP021442MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Slc22a1重組蛋白
  • 貨號：
    CSB-BP021442MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Slc22a1重組蛋白
  • 貨號：
    CSB-MP021442MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc22a1
  • Uniprot No.：
  • 別名：
    Slc22a1; Lx1; Oct1; Solute carrier family 22 member 1; Organic cation transporter 1; mOCT1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase.
  • 基因功能參考文獻：
    1. we unraveled substrate affinities and modulation of transport activity by acute regulation by protein kinases on mOCT1 and mOCT2 PMID: 24233562
    2. Data indicate that the expression of the organic cation transporters Slc22a1, Slc22a2 and Slc22a3 essential for the cellular uptake of metformin was highly suppressed in Tsc1+/-renal tumours. PMID: 23228442
    3. Transcripts encoding OCT1-3 and ChAT (choline acetyltransferase) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen. PMID: 22300281
    4. The influence of organic cation transporters 1, 2, and 3 (OCT1, OCT2, and OCT3) and their genetic variants on cellular uptake of picoplatin and on the individual components of the ensuing cytotoxicity such as DNA adduct formation, was determined. PMID: 20371711
    5. Oct1 forms repeating, cyclosporin-sensitive regulatory modules within the CD21 intronic control region. PMID: 11907091
    6. rOCT1 could transport the nucleoside analog deoxytubercidin PMID: 12123738
    7. Involvement in hepatic and intestinal distribution of metformin. PMID: 12130709
    8. a comparison of the transport properties of Oct2 and Oct1 PMID: 12176030
    9. oct1 has a role in controlling fgl2 expression in endothelial cells PMID: 12752447
    10. This study shows that Oct1 and Oct2 together are essential for renal secretion of (small) organic cations. PMID: 14560032
    11. nuclear factor Y and Oct-1 bind to the SURG-1 element to direct basal and gonadotropin-releasing hormone (GnRH)-stimulated expression of the mGnRH receptor gene PMID: 15388790
    12. The purpose of this study was to examine the effects of peroxisome proliferator agonist receptor agonists on the hepatic regulation and function of Slc22a1. PMID: 15458920
    13. a multiprotein complex containing GATA-1, Oct-1, and other protein factors may contribute to the formation of a repressive chromatin structure that silences gamma-globin gene expression PMID: 15613485
    14. Oct-1 has an important role in IFN-A regulation PMID: 16166650
    15. Doubling of airway epithelial acetylcholine (ACh) in OCT1/2-/- mice is consistent with OCT1 and/or 2 mediating ACh release from respiratory epithelium. This effect does not contribute to 5-HT-induced constriction of murine intrapulmonary bronchi. PMID: 16608531
    16. The ubiquitous Oct-1 transcription factor may be involved in hormonally regulated, tissue-specific beta-casein gene expression. PMID: 16965262
    17. Real-time RT-PCR revealed significant decreases in OCT1 mRNA in the lung of sensitized and allergen challenged animals. PMID: 17328924
    18. Genetic variation in OCT1 may contribute to variation in individual response to the drug. PMID: 17476361
    19. Effect of OCT1 genotype on metformin pharmacokinetics in mice was less than in humans. PMID: 17609683
    20. the interaction of glucocorticoid receptor with Oct-1 on the beta-casein gene promoter PMID: 19266165

    顯示更多

    收起更多

  • 亞細胞定位：
    Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
  • 組織特異性：
    Highly expressed in liver, kidney and intestine. Weakly expressed in adrenals and in lacting mammary glands.
  • 數據庫鏈接：

    KEGG: mmu:20517

    STRING: 10090.ENSMUSP00000024596

    UniGene: Mm.594



主站蜘蛛池模板： 另类亚洲综合区图片小说区| 亚洲成av人片久久| 亚洲精品国产电影| 国产嘿嘿嘿视频在线观看| 99精品国产高清一区二区麻豆| 人妻av综合天堂一区| 日韩人妻一区二区三区免费| 中国精品偷拍区偷拍无码| 亚洲中文无码av永久伊人| 把插八插露脸对白内射| 性做久久久久久| 无码h肉在线观看免费一区| 少妇熟女久久综合网色欲| 青青草原亚洲| 8天堂资源在线| 天堂最新版资源网| 天天爽夜夜爽视频精品| 国产成人一区二区三区| 亚洲乱码国产乱码精品精大量 | 亚洲综合色婷婷六月丁香宅男大增| 人妻系列无码一区二区三区| 久久久亚洲一区二区三区| 丰满少妇人妻久久久久久| 日本国产成人国产在线播放| 欧美xxxx做受视频| 亚洲欧洲日产国码无码久久99| 国产亚洲精品久久久性色情软件| 亚洲色欲色欲www成人网| 国产成人亚洲综合| 国模裸体无码xxxx视频| 国产欧美日韩综合在线成| 人妻熟女一区二区三区app下载 | 国产精品视频一区二区噜噜| 国产又大又粗又爽的毛片| 国产精品无码2021在线观看| 中文字幕制服丝袜人妻动态图| 熟睡人妻被讨厌的公侵犯| av无码人妻一区二区三区牛牛| 再深点灬舒服灬太大了在线视频| 欧美日韩视频无码一区二区三| 最近2019免费中文第一页|