在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Sodium/potassium/calcium exchanger 6 (Slc24a6), partial

Recombinant Mouse Sodium/potassium/calcium exchanger 6 (Slc24a6), partial

  • 中文名稱：
    小鼠Slc8b1重組蛋白
  • 貨號(hào)：
    CSB-YP835683MO
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Slc8b1重組蛋白
  • 貨號(hào)：
    CSB-EP835683MO
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Slc8b1重組蛋白
  • 貨號(hào)：
    CSB-EP835683MO-B
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Slc8b1重組蛋白
  • 貨號(hào)：
    CSB-BP835683MO
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Slc8b1重組蛋白
  • 貨號(hào)：
    CSB-MP835683MO
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc8b1
  • Uniprot No.：
  • 別名：
    Slc8b1; Nckx6; Nclx; Slc24a6; Mitochondrial sodium/calcium exchanger protein; Na(+)/K(+)/Ca(2+)-exchange protein 6; Sodium/calcium exchanger protein; mitochondrial; Sodium/potassium/calcium exchanger 6; Solute carrier family 24 member 6; Solute carrier family 8 member B1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion. Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes. Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity. Involved in B-lymphocyte chemotaxis. Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+).
  • 基因功能參考文獻(xiàn)：
    1. Results found that NCLX reduction/inhibition markedly suppressed chemotaxis while increasing the random migration of B lymphocytes. In addition, the contributions of NCLX to motility were observed only in B lymphocytes and not in T lymphocytes. PMID: 27328625
    2. tamoxifen-induced deletion of Slc8b1 in adult mouse hearts causes sudden death, with less than 13% of affected mice surviving after 14 days; lethality correlated with severe myocardial dysfunction and fulminant heart failure PMID: 28445457
    3. NCLX mediates the mitochondrial Na(+) influx and is tuned to sense the TTX-sensitive cytosolic Na(+) responses. PMID: 24719357
    4. NCLX is a novel molecule to regulate automaticity of cardiomyocytes via modulating sarcoplasmic reticulum Ca(2+) handling. PMID: 24067497
    5. Silencing of NCLX expression significantly reduces Ca2+-dependent processes in astrocytes. PMID: 23616530
    6. The findings suggest that the mitochondrial Na(+)/Ca(2+) exchanger, NCLX, shapes glucose-dependent mitochondrial and cytosolic Ca(2+) signals thereby regulating the temporal pattern of insulin secretion in beta cells. PMID: 23056385
    7. data provide evidence for the presence of an electrogenic Na(+)/Ca(2+) exchanger that is capable of regulating [Ca(2+)](i) after release of Ca(2+) from cell stores PMID: 11940515
    8. Presence of a Na(+)-Ca(2+) exchanger in podocytes and its regulation by PKC. PMID: 12270979
    9. Ca(2+) entering the myocyte via NCX can cause Ca(2+) sparks which are similar to those elicited by electrical stimulation. However, Ca(2+) influx on NCX is much less efficient in inducing Ca(2+) sparks than Ca(2+) influx via I(Ca,L). PMID: 12767888
    10. An electrophysiologically distinct subset of arcuate nucleus neurons coexpress orexin receptors and glutamate decarboxylase-67 and are excited by orexin, activating a sodium-calcium exchange current, thereby depolarizing the cell and increasing its firing PMID: 12832517

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein. Note=Mainly localizes to mitochondrion inner membrane (PubMed:20018762).; [Isoform 2]: Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC24A subfamily
  • 組織特異性：
    Ubiquitously expressed. Expressed in dental tissues.
  • 數(shù)據(jù)庫(kù)鏈接：


主站蜘蛛池模板： 国产v综合v亚洲欧| 国产成人av大片大片在线播放| 免费无遮挡无码视频网站| 久久精品国产第一区二区三区| 人妻少妇-嫩草影院| 又黄又湿啪啪响18禁| 久久av高潮av无码av喷吹| 夜夜影院未满十八勿进| 欧美孕妇乳喷奶水在线观看| 国产超碰人人做人人爽av动图| 久久青青草免费线频观| 久久丫精品久久丫| 国产麻豆精品久久一二三| 亚洲国产精品第一区二区三区| 夜夜夜夜猛噜噜噜噜噜| 5566先锋影音夜色资源站在线观看| 乱码午夜-极国产极内射| 最新69成人精品视频免费| 好男人社区www在线观看| 国产成人精品a视频| 亚洲欧洲日产最新| 久久99精品久久久久久蜜芽| 大胆欧美熟妇xxbbwwbw高潮了| 成人精品视频一区二区三区| 夜晚被公侵犯的人妻深田字幕| 国产精品∧v在线观看| 四川丰满妇女毛片四川话| 欲色影视天天一区二区三区色香欲 | 久久精品人人做人人爱爱漫画| 亚洲色欲色欱www在线| 日韩精品乱码av一区二区| 国产成人av无码永久免费一线天 | 中文字幕无码精品亚洲资源网| av无码精品一区二区三区四区| 伊人激情av一区二区三区| 人妻系列无码专区av在线 | 美女人妻激情乱人伦| 欧美肥老太交性506070| 亚洲色偷偷色噜噜狠狠99网| 日本熟妇色高清免费视频| 狠日狠干日日射|