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  4. Recombinant Mouse Serum paraoxonase/lactonase 3 (Pon3)

Recombinant Mouse Serum paraoxonase/lactonase 3 (Pon3)

  • 中文名稱：
    小鼠Pon3重組蛋白
  • 貨號：
    CSB-YP737067MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Pon3重組蛋白
  • 貨號：
    CSB-EP737067MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Pon3重組蛋白
  • 貨號：
    CSB-BP737067MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Pon3重組蛋白
  • 貨號：
    CSB-MP737067MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Pon3
  • Uniprot No.：
  • 別名：
    Pon3; Serum paraoxonase/lactonase 3; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-354
  • 氨基酸序列
    GKLVALTLL GACLALIGER LLNFRERVST TREIKATEPQ NCHLIEGLEN GSEDIDILPS GLAFISTGLK YPGMPAFAPD KPGRIFLMDL NEQNPEAQAL EISGGLDQES LNPHGISTFI DKDNTAYLYV VNHPNMDSTV EIFKFEEQQR SLIHLKTLKH ELLKSVNDIV VLGPEQFYAT RDHYFTSYFL VLLEMILDPH WTSVVFYSPK EVKVVAQGFS SANGITVSLD QKFVYVADVT AKNIHIMKKH DNWDLTPVKV IQLGTLVDNL TVDPATGDIL AGCHPNPMKL LIYNPEDPPG SEVLRIQDSL SDKPRVSTLY ANNGSVLQGS TVASVYHKRM LIGTIFHKAL YCDL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
  • 基因功能參考文獻：
    1. study suggests a role for PON3 in the metabolism of lipid and bile acid as well as protection against atherosclerosis, gallstone disease, and obesity PMID: 25477283
    2. PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death. PMID: 22441669
    3. investigation of effect of knockout of Pon3 in embryo: Data suggest that Pon3-/- mice exhibit increased early embryonic and neonatal mortality. PMID: 21952037
    4. mouse Pon3 is expressed in a wide range of tissues, and that its expression is temporally controlled PMID: 20221872
    5. PON3 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli. PMID: 20931267
    6. The anti-atherogenic biological activities were studied in vitro using serum or cell cultures, and also in vivo, using PON 1/2/3 knockout or transgenic mice, as well as humans - healthy volunteers and atherosclerotic patients. PMID: 19082953
    7. The directed evolution and characterization of recombinant variants of serum paraoxonase PON3, is described. PMID: 19492856

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  • 亞細胞定位：
    Secreted, extracellular space.
  • 蛋白家族：
    Paraoxonase family
  • 數據庫鏈接：


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