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  4. Recombinant Mouse Sentrin-specific protease 1 (Senp1)

Recombinant Mouse Sentrin-specific protease 1 (Senp1)

  • 中文名稱：
    小鼠Senp1重組蛋白
  • 貨號：
    CSB-YP021008MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Senp1重組蛋白
  • 貨號：
    CSB-EP021008MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Senp1重組蛋白
  • 貨號：
    CSB-EP021008MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Senp1重組蛋白
  • 貨號：
    CSB-BP021008MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Senp1重組蛋白
  • 貨號：
    CSB-MP021008MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Senp1
  • Uniprot No.：
  • 別名：
    Senp1; Supr2; Sentrin-specific protease 1; EC 3.4.22.-; SUMO-1 protease 2; SuPr-2; Sentrin/SUMO-specific protease SENP1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-640
  • 氨基酸序列
    MDDTADGVKM DAGEVTLVNH GSTFRTHRPP QSGFPEEQLL LSDQQSLPFR QGTLDGSFTC STRSPAYRPD YHSDNPSSDS FLGSGDVRTF GQSANGQWRN STPASGSAPQ KPRNSRSLCL ETRKTSSGLS NTFVGKSNHH CHMSAYEKSF PIKPAPSPSW SGSCRRSLLS PKKTQRRHFS TAEETVQEEE KEIYRQLLQM VTGKQFCVAK PTTHFPLRLS RCLSSNKNSL KDSLLRNGNS CASHVIGSDT SSSGSASILT AQEQLSHSAH SLSSGTPDVA FGSKDSDPHH HLAAPHQPNS LPASNTQSEG SDSVILLKVK ESQTPASSPT FFQAELWIKE LTSVYDSRAR ERLRRIEEQK ALALQLQNQR LQEQEHAVLD SVELHLRVPL EKEIPVTAAQ ETRKKSHQLT DSEDEFPEIT EEMEKEIKNV FRNGNQDEVL SEAFRLTITR KDIQTLNHLN WLNDEIINFY MNMLMERSKE KGFPSVHAFN TFFFTKLKTA GYQAVKRWTK KVDVFSVDIL LVPIHLGVHW CLAVVDFRRK SITYYDSMGG INNEACRILL QYLKQESVDK KRKEFDTNGW QLFSKKSQEI PQQMNGSDCG MFACKYADCI TKDRPINFTQ QHMPYFRKRM VWEILHRKLL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Deconjugates SUMO2 from MTA1. Deconjugates SUMO1 from METTL3. Desumoylates CCAR2 which decreases its interaction with SIRT1. Deconjugates SUMO1 from GPS2.
  • 基因功能參考文獻：
    1. endothelial SENP1-mediated SUMOylation drives graft arteriosclerosis by regulating the synergistic effect of GATA2 and NF-kappaB and consequent endothelial dysfunction. PMID: 28569748
    2. knockdown of SENP1 augments the ability of Shh to sustain the proliferation of cerebellar granule cell precursors, demonstrating the physiological significance of the negative regulation of Shh signaling by SENP1. PMID: 28630282
    3. SUMO1 conjugation of RB and Lamin A/C is modulated by the SUMO protease SENP1 and that sumoylation of both proteins is required for their interaction. PMID: 27270425
    4. SENP1 plays a neuroprotective role in ischemia/reperfusion injury. PMID: 27882949
    5. a novel negative feedback loop mediated by STAT3-SOCS3, which is tightly controlled by SENP1 via de-SUMOylation of protein tyrosine phosphatase 1B (PTP1B), in IFN-gamma signaling, is reported. PMID: 27702761
    6. SENP1 deletion in adipocytes causes Type 1 diabetes mellitus via enhanced SUMOylation of NEMO, leading to increased NF-kappaB activity, cytokine production and pancreatic inflammation. PMID: 26596471
    7. results of the present study are of both theoretical and therapeutic significance to explore the potential roles of SENP1 under IH condition and elucidated the mechanisms underlying microglial survival and activation PMID: 26499079
    8. A role for islet SENP1 as a regulator of in vivo glucose homeostasis was demonstrated by the tissue-selective and inducible knockout of this enzyme. PMID: 26389676
    9. SENP1 up-regulation in diseased heart is mediated via calcineurin-NFAT/MEF2C-PGC-1alpha pathway. PMID: 25446185
    10. SENP1 deficiency exacerbates ischemia-reperfusion injury in cardiomyocytes via a HIF1alpha-dependent pathway. PMID: 25082844
    11. Senp1 Is the Primary Activity for Desumoylation of Sumo1-Modified Proteins. PMID: 23684609
    12. SENP1 is a specific SUMO protease to regulate SUMOylation status of PGC-1alpha. PMID: 23152500
    13. SENP1 is essential for cell survival during endoplasmic reticulum stress. PMID: 22370484
    14. SENP1 is essential for the development of early T and B cells. PMID: 22284677
    15. Data indicates that SENP1 overexpression induces transformation of the normal prostate gland and gradually facilitates the onset of high-grade prostatic intraepithelial neoplasia. PMID: 20551310
    16. SENP1 promotes GATA1 activation and subsequent erythropoiesis by deSUMOylating GATA1. PMID: 20457756
    17. Data describe a mutation in SENP1 that causes increased steady-state levels of the sumoylated forms of a number of proteins and results in placental abnormalities incompatible with embryonic development. PMID: 15923632
    18. These results show that SENP1 plays a key role in the regulation of the hypoxic response through regulation of HIF1alpha stability and that SUMOylation can serve as a direct signal for ubiquitin-dependent degradation. PMID: 17981124

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  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Peptidase C48 family
  • 數據庫鏈接：


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