在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse SH2B adapter protein 3 (Sh2b3)

Recombinant Mouse SH2B adapter protein 3 (Sh2b3)

  • 中文名稱：
    小鼠Sh2b3重組蛋白
  • 貨號：
    CSB-YP021208MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Sh2b3重組蛋白
  • 貨號：
    CSB-EP021208MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Sh2b3重組蛋白
  • 貨號：
    CSB-EP021208MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Sh2b3重組蛋白
  • 貨號：
    CSB-BP021208MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Sh2b3重組蛋白
  • 貨號：
    CSB-MP021208MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Sh2b3; Lnk; SH2B adapter protein 3; Lymphocyte adapter protein; Lymphocyte-specific adapter protein Lnk; Signal transduction protein Lnk
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-548
  • 氨基酸序列
    MNEPTVQPSR TSSAPASPAS PRGWSDFCEQ HAAAAARELA RQYWLFARAH PQPPRADLVS LQFAELFQRH FCREVRESLA GPPGHDYRAT APPRPALPKA RSSEDLGPRP ACALQHLRRG LRQLFRRRSA GELPGATSDT NDIDTTAASR PGPARKLLPW GLREPPTEAL KEVVLRYSLA DEAAMDSGAR WQRGRLVLRS PGPGHSHFLQ LFDPPKSSKP KLQEACSSIR EVRPCTRLEM PDNLYTFVLK VQDQTDIIFE VGDEQQLNSW LAELRASTGL GLEHPDTELP LSLAAEPGPA RSPRGSTDSL DQGASPGVLL DPACQKTDHF LSCYPWFHGP ISRVRAAQLV QLQGPDAHGV FLVRQSESRR GEYVLTFNLQ GRAKHLRLVL TERGQCRVQH LHFPSVVDML RHFQRSPIPL ECGAACDVRL SGYVVVLSQA PGSSNTVLFP FSLPHWDSEL GHPHLSSVGC PPSHGAEALP GQVTPPEQIF HLVPSPEELA NSLRQLELES VSSARDSDYD MDSSSRGHLR AIDNQYTPLS QLCREADV
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
  • 基因功能參考文獻：
    1. Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype PMID: 28067429
    2. Specific targeting of Lnk may be a promising EPC-based therapeutic strategy for dermal wound healing. PMID: 27793180
    3. The LNK plays a regulatory role in the palmitate-related preadipocyte apoptosis and might be involved in adipose tissue dysfunction. PMID: 28526415
    4. We found that a significant number of genes predicted to be regulated by SH2B3 in gene networks are perturbed in Sh2b3(-/-) mice, which demonstrate an exaggerated pressor response to angiotensin II infusion. PMID: 25882670
    5. SH2B3 functions as a novel and effective modulator of cardiac remodeling and failure. PMID: 26101343
    6. Loss of LNK in hematopoietic cells is primarily responsible for the observed renal and vascular inflammation and predisposition to hypertension. PMID: 25664851
    7. Lnk/Sh2b3 plays a regulatory role in the expansion of Dendritic cells and might influence inflammatory immune responses in peripheral lymphoid tissues. PMID: 25024389
    8. results reveal a link between Lnk and immune cell-mediated intestinal tissue destruction. PMID: 24536025
    9. Report that Lnk siRNA-transfected endothelial commitment of c-kit+/Sca-1+/lineage bone marrow cells have high hematopoietic stem/endothelial progenitor cells (EPCs) colony-forming capacity exhibiting endothelial markers, VE-Cad, VEGF and Ang-1. PMID: 23897412
    10. Lnk deficiency partially mitigates hematopoietic stem cell aging. PMID: 22812478
    11. that the SH2B3 mutation is absent in NOD mice. To our knowledge, this is the first report of the sequence and the protein levels of SH2B3 in NOD mice PMID: 22614355
    12. LNK as a stroke-specific, endogenous negative regulator of neural stem and progenitor cell proliferation PMID: 22496561
    13. Hematopoietic stem cells in patients with an Lnk/Sh2b3 mutation might become resistant to apoptosis due to thrombopoietin-mediated enhanced expression of Bcl-xL. PMID: 22101255
    14. Loss of Foxo3 causes a myeloproliferative syndrome with increased intracellular ROS, overactive intracellular signalling through the AKT/mTOR signalling pathway and relative deficiency of Lnk, a negative regulator of cytokine receptor signalling. PMID: 21113129
    15. the loss of Lnk signaling enhances the regenerative response during fracture healing PMID: 20855498
    16. Lnk binds to c-Fms and can blunt M-CSF stimulation PMID: 20571037
    17. Findings suggest that Lnk deletion reinforces the commitment of KSL cells to EPCs, promoting subsequent repair of injured spinal cord through the acceleration of angiogenesis and astrogliosis. PMID: 19859984
    18. Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. PMID: 20038804
    19. Lnk plays critical roles in the expansion and function of early hematopoietic progenitors PMID: 11805142
    20. Lnk overexpression in transgenic mice results in impaired expansion of lymphoid precursor cells and altered mature B cell subpopulations. PMID: 12517931
    21. regulates production of B cells and hematopoietic stem cells--review PMID: 12518435
    22. Lnk is a negative regulator of hematopoiesis in the aorta-gonad-mesonephros region PMID: 14612394
    23. Lnk, SH2-B, and APS have roles in mast cell development, growth, and functions PMID: 14766215
    24. Lnk negatively modulates mpl-tpo signaling pathways PMID: 15337790
    25. Transient inhibition of Lnk or Lnk-mediated pathways could be a potent approach to augment engraftment of hematoopietic stem cells/hematopoietic progenitor cells. PMID: 16332975
    26. Lnk-deficient HSCs are hypersensitive to TPO; Competitive repopulation revealed that long-term repopulating activity increases in Lnk-deficient HSCs, but not in WT HSCs, when these cells are cultured in the presence of TPO with or without stem cell factor PMID: 17284614
    27. Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders. PMID: 17693582
    28. contact of MKs with adhesion molecules via integrins might contribute to platelet release, which is under Lnk-mediated regulation of Stat-5 activation PMID: 18456388
    29. Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2. PMID: 18618018
    30. suggest pivotal role of lnk adaptor protein in endothelial progenitor cell biology for vascular regeneration. PMID: 19325148

    顯示更多

    收起更多

  • 蛋白家族：
    SH2B adapter family
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 狠狠色狠狠人格综合| 中国大陆精品视频xxxx| 国产香蕉97碰碰久久人人| 亚洲欧洲自拍拍偷午夜色| 无码av中文字幕久久专区| 伊人大香人妻在线播放| 天堂亚洲2017在线观看| 亚洲一区二区三区乱码在线欧洲 | 老熟女重囗味hdxx70星空| 激情综合一区二区三区| 免费无码毛片一区二三区| 无码h片在线观看网站| 国产乱人伦av在线a更新| 午夜av亚洲一码二中文字幕青青| 天天躁日日躁狠狠躁性色av| 极品美女扒开粉嫩小泬图片| 亚洲中文字幕无码爆乳| 免费视频爱爱太爽了| 日韩经典精品无码一区| 在线无码av一区二区三区| 日本乱偷人妻中文字幕| 久久无码av三级| 午夜福利影院私人爽爽| 国产精品毛片更新无码| 最近日本免费观看高清视频 | 在线亚洲高清揄拍自拍一品区| 超级大爆乳奶牛被调教出奶水| 亚洲女人被黑人巨大进入| 色噜噜狠狠色综合成人网| 鲁丝片一区二区三区毛片| 香蕉久久国产超碰青草| 日本特黄aaaaaa大片| 西西人体www大胆高清视频| 欧美成人免费全部观看国产| 伊人久久丁香色婷婷啪啪| 国产女主播白浆在线看| 极品少妇被猛的白浆直喷白浆| 欧美人与动人物牲交免费观看久久 | 成年女人色毛片| 国产乱码免费卡1卡二卡3| 2020年无码国产精品高清免费|