在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse SH2B adapter protein 2 (Sh2b2)

  • 中文名稱:
    小鼠Sh2b2重組蛋白
  • 貨號:
    CSB-YP888308MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Sh2b2重組蛋白
  • 貨號:
    CSB-EP888308MO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小鼠Sh2b2重組蛋白
  • 貨號:
    CSB-EP888308MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Sh2b2重組蛋白
  • 貨號:
    CSB-BP888308MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Sh2b2重組蛋白
  • 貨號:
    CSB-MP888308MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Sh2b2; ApsSH2B adapter protein 2; Adapter protein with pleckstrin homology and Src homology 2 domains; SH2 and PH domain-containing adapter protein APS
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-621
  • 氨基酸序列
    MNGATPSSAA APAPVPDWRQ FCELHAQVAA VDFAHKFCRF LRDNPTYDTP DAGTSFSRHF AANFLAVFSE EVRRVLGSAA DTMEPEPAVT SVTSALKTAT YGHSRSSEDV SAHAATKARV RKGFSLRNMS LCVVDGVRDL WHRRSSPEPD GGATPKAAEP ASEPRDKWTR RLRLARTLAA KVELVDIQRE GALRFMVADD AASGPGGTAQ WQKCRLLLRR AVAGERFRLE FFVPPKASRP KVSIPLSAII EVRTTMPLEM PEKDNTFVLK VENGAEYILE TIDSLQKHSW VADIQGCVDP GDSEEDTGLS CARGGCLASR VASCSCELLT DADMPRPPET TTAVGAVVTA PHGRARDTVG ESLAHVPLET FLQTLESSGG VSENNNPGDE GAELDTDAEA ELELSDYPWF HGTLSRVKAA QLVLAGGPRS HGLFVIRQSE TRPGECVLTF NFQGKAKHLR LSLNGHGQCH VQHLWFQSVF DMLRHFHTHP IPLESGGSAD ITLRSYVRAQ GPPPDPGPAP NTAAPVPACW TEPAGQHYFS SLATATCPPA SPSNGAGASS SSGSSSSATS LPPRPAEGPL SAHSRSNSTE HLLDAASGAT EEPTEATLGR ARAVENQYSF Y
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.
  • 基因功能參考文獻:
    1. Deletion of liver SH2B1 in SH2B2 null mice attenuated very low-density lipoprotein (VLDL) secretion. PMID: 24358267
    2. Data show that the adapter protein APS preferentially associates with phosphorylated Tyr-568 and Tyr-936 of the receptor for stem-cell factor (c-Kit). PMID: 12444928
    3. APS might have a novel regulatory role in actin reorganization and control of B-1 cell compartment size. PMID: 14993264
    4. Knockdown of the mouse APS gene abolished the insulin-stimulated phosphorylation of c-Cbl. PMID: 15031295
    5. APS appears to play novel negative regulatory roles in BCR signaling, actin reorganization pathways, and control of compartment sizes of B-lineage cells PMID: 15809095
    6. These results identify Enigma as a novel APS-binding protein and suggest that the APS/Enigma complex plays a critical role in actin cytoskeleton organisation. PMID: 15946664
    7. APS enhanced ligand-dependent multi-ubiquitination of the insulin receptor (IR) in CHO cells. PMID: 17102568
    8. SH2B2beta is an endogenous inhibitor of SH2B1 and/or SH2B2alpha, negatively regulating insulin signaling and/or JAK2-mediated cellular responses. PMID: 17204555
    9. The association between SHIP2 and the adaptor protein Aps has an impact on biochemical properties of both partners. PMID: 17620296

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane.
  • 蛋白家族:
    SH2B adapter family
  • 組織特異性:
    Strongly expressed in brain; also expressed in spleen, kidney and skeletal muscle, and at low levels in small intestine and bone marrow. Strongly expressed in B-cell lines, but not T-cell lines. Also expressed in myeloid and fibroblast cell lines.
  • 數據庫鏈接:


主站蜘蛛池模板: 让少妇爽到高潮视频| 大香线蕉伊人超碰| 国产精品igao视频网网址| 亚洲精品国产综合久久一线| 撕开奶罩揉吃奶高潮av在线观看| 久久久久久av无码免费网站| 久久人人玩人妻潮喷内射人人| √天堂中文www官网在线| 波多野结衣av在线无码中文18 | 永久免费看啪啪网址入口| 色五月激情五月| 午夜精品久久久久久久久久久久| 亚洲日韩片无码中文字幕| 国产精品久免费的黄牛仔短裤 | 夜夜高潮夜夜爽夜夜爱爱| 国产亚洲精品美女久久久久| 在线播放无码后入内射少妇| 亚洲欧美日本中文字不卡 | 久久国产乱子伦免费精品| 四虎国产精品免费久久久| 熟睡人妻被讨厌的公侵犯深田咏美| 久久综合九色综合欧美婷婷| 加勒比中文无码久久综合色| 色吊丝中文字幕| 波多野结衣在线播放| 日本午夜精品一区二区三区电影| 久久九九精品国产免费看小说 | 精品综合久久久久久97| 蜜桃视频一区二区三区在线观看 | 插一插射一射视频| 久久人搡人人玩人妻精品首页| 97久久超碰国产精品最新| 小污女导航福利入口| 成av人片一区二区三区久久| 无码熟妇人妻av在线影片| 最新精品视频2019在线视频| 久久99av无色码人妻蜜| 国产一区日韩二区欧美三区| 西西人体做爰大胆gogo| 琪琪秋霞午夜av影视在线| 色欲aⅴ 无码|