在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Rho-related GTP-binding protein RhoB (Rhob)

Recombinant Mouse Rho-related GTP-binding protein RhoB (Rhob)

  • 中文名稱：
    小鼠Rhob重組蛋白
  • 貨號：
    CSB-YP019683MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Rhob重組蛋白
  • 貨號：
    CSB-EP019683MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Rhob重組蛋白
  • 貨號：
    CSB-EP019683MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Rhob重組蛋白
  • 貨號：
    CSB-BP019683MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Rhob重組蛋白
  • 貨號：
    CSB-MP019683MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Rhob; Arhb; Rho-related GTP-binding protein RhoB
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-193
  • 氨基酸序列
    MAAIRKKLVV VGDGACGKTC LLIVFSKDEF PEVYVPTVFE NYVADIEVDG KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSVDSPD SLENIPEKWV PEVKHFCPNV PIILVANKKD LRSDEHVRTE LARMKQEPVR TDDGRAMAVR IQAYDYLECS AKTKEGVREV FETATRAALQ KRYGSQNGCI NCC
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
  • 基因功能參考文獻：
    1. These results highlight a newly identified function for RhoB in supporting the specific production of pathogenic autoantibodies. PMID: 28882929
    2. the histone deacetylase inhibitor trichostatin A increased miR-223 expression obviously in TLR-triggered macrophages, which in turn suppressed RhoB expression and downstream IL-6 production, suggesting that the inhibition of miR-223 by histone deacetylation may be involved in the regulation of TLR-activated inflammatory response. PMID: 28881218
    3. these results suggest that RhoB plays an important role in the hypoxia-induced activation of macrophages and the inflammatory response. PMID: 26388235
    4. RhoB-deficient cells accumulate endogenous gammaH2AX and chromosomal abnormalities, suggesting that RhoB loss increases double-strand break-mediated genomic instability and tumor progression. PMID: 24912678
    5. Loss of RhoB decreases pathological angiogenesis in the ischemic retina and reduces angiogenesis in response to cutaneous wounding, but enhances lymphangiogenesis following both dermal wounding and inflammatory challenge PMID: 24280686
    6. UVB-induced RhoB expression participates in in vivo squamous cell carcinoma initiation by increasing keratinocyte survival. PMID: 23792460
    7. the cytoprotective RhoB response is not only evoked by bacterial protein toxins inactivating Rho/Ras proteins but also by the Rac1-activating toxin CNF1. PMID: 23732113
    8. In cancer cells in vitro or in vivo, RhoB functions as a tumor suppressor that restricts EGF receptor (EGFR) cell surface occupancy as well as Akt signaling PMID: 23135917
    9. RhoB mediates adaptational changes to acute hypoxia in the vasculature, but its continual activation by chronic hypoxia can accentuate vascular remodeling to promote development of pulmonary hypertension. PMID: 22539766
    10. These data directly implicate neuronal RhoB in caspase 3 activation and the initial stages of programmed cell death. PMID: 22098422
    11. miR-21 as a new angiogenesis inhibitor through repression of RhoB PMID: 21347332
    12. findings strongly support a physiological role of RhoB in regulation of thymus development and maintenance through the inhibition of TGF-beta signaling in thymic medullary epithelium PMID: 21865151
    13. RhoB links PDGF signaling to cell migration by coordinating activation and localization of Cdc42 and Rac. PMID: 21344485
    14. RhoB is a modifier of diabetes, important for the induction of beta-cell loss. PMID: 21224061
    15. These data implicate RhoB in cofilin regulation and dendritic and spine morphology, highlighting its importance in synaptic plasticity at a structural and functional level. PMID: 20203211
    16. RhoB-regulated mDia1 has a role in the regulation of hematopoietic progenitor cells PMID: 19768111
    17. Results suggest that constitutive activation of the Rho-ROCK-LIM kinase pathway by extracellular production of lysophosphatidic acid by the action of autotaxin is required to maintain the large size of lysosomes in visceral endoderm cells. PMID: 19808661
    18. RhoB is dispensable for normal cell physiology but it has a suppressor or negative modifier function in stress-associated processes including cancer. PMID: 11905808
    19. RhoB isoprenylation is necessary for its rapid turnover; there is a link between the cholesterol biosynthetic pathway and the regulation of G-protein expression PMID: 12384510
    20. The geranylgeranyltransferase-I inhibitor GGTI-298 inhibits the RhoB pathway and disrupts stress fiber and focal adhesion formation in NIH-3T3 cells. PMID: 12548020
    21. RhoB expression is suppressed by EGFR, ErbB2 and Ras, but not Src. PMID: 14647415
    22. RhoB has a role as a tumor suppressor in lung neoplasms PMID: 15102679
    23. suppression of RhoB as a mechanism by which the Ras/PI3K/Akt pathway induces tumor survival, transformation, invasion, and metastasis PMID: 15169915
    24. Ultraviolet light induces stress-activated signal transduction leading to nuclear/cytoplasmic shuttling of HuR proteinand subsequent stabilization of RhoB mRNA. PMID: 15543229
    25. RhoB mediated transcriptional suppression but also accumulation of Cyclin B1 in the cytosol at early times after farnesyl transferase inhibitor treatment, at a time before the subsequent reduction in steady-state protein levels PMID: 15548709
    26. RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane PMID: 15572128
    27. RhoB-F and RhoB-GG which differ only by a 5-carbon isoprene behave differently in rodent cells highlighting the important role of prenyl groups in protein function and emphasize the potency of RhoB to regulate negatively the oncogenic signal. PMID: 15748883
    28. Farnesylated Rhob inhibits radiation-induced mitotic cell death and controls radiation-induced centrosome overduplication. PMID: 15776002
    29. The ability of RhoB to support GSK-3-dependent turnover of c-Myc offers a mechanism by which RhoB acts to limit the proliferation of neoplastically transformed cells PMID: 16247449
    30. These data suggest that, although RhoB is expressed by Muller cells in chick and mouse, its role in the maintenance of cellular morphology and regulation may be different. PMID: 16385489
    31. RhoB was upregulated by Rho-/Ras-inactivating toxins, as a consequence of the inactivation of either Rho(A,B,C) or (H-,K-,N-)Ras. In TcdB-treated cells, RhoB escaped its inactivation and was required for the cytotoxic effect. PMID: 17397186
    32. RhoB affects cell shape and migration by regulating surface integrin levels. PMID: 17692842
    33. mouse RhoB transcription is epigenetically regulated in a tissue-specific manner during aging by histone modification, but not by CpG methylation PMID: 17706596
    34. Suggest RhoB is a critical regulator of PDGFR-beta trafficking and signaling in vascular smooth muscle cells. PMID: 17951322
    35. Vibrio parahaemolyticus induces a rapid remodeling of macrophage actin and activates RhoB GTPase via translocation of VP1686. PMID: 18239436
    36. In vivo restoration of RhoB expression leads to ovarian tumor regression. PMID: 18340357
    37. Rhob plays an important role in the antiproliferative effect of glucocorticoid receptor (GR) on RAW264.7 cells. PMID: 18840672
    38. Rhob expression is associated with hematopoietic stem cells that have durable self-renewal potential PMID: 19377048
    39. RhoB is essential for apoptosis and antineoplastic activity of farnesyltransferase inhibitors in a mouse model. PMID: 10913192
    40. Loss of RhoB did not adversely affect mouse development, fertility, or wound healing. However, embryo fibroblasts cultured in vitro exhibited a defect in motility, suggesting that RhoB has a role in this process that is conditional on cell stress PMID: 11564874

    顯示更多

    收起更多

  • 亞細胞定位：
    Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow.
  • 蛋白家族：
    Small GTPase superfamily, Rho family
  • 數據庫鏈接：

    KEGG: mmu:11852

    STRING: 10090.ENSMUSP00000067013

    UniGene: Mm.687



主站蜘蛛池模板： 亚洲熟妇无码av另类vr影视| 奇米影视第4色| 内射干少妇亚洲69xxx| 性色欲情网站| 美女扒开腿让男人桶爽app免费看| 又大又紧又粉嫩18p少妇| 国产午夜精品一区理论片飘花 | 国产乡下三级全黄三级| 少妇人妻av毛片在线看| 色欲综合久久躁天天躁蜜桃| 人妻少妇无码专视频在线| 亚洲va中文字幕无码毛片| 一二三四免费观看在线视频中文版| 精品香蕉久久久午夜福利| 色偷偷久久一区二区三区| 午夜精品一区二区三区在线观看| 成人性生交大片免费看96| 五月婷婷之综合缴情| 久久97久久97精品免视看| 亚洲精品乱码久久久久久蜜桃 | 偷柏自拍亚洲综合在线| 欧美牲交a欧牲交aⅴ久久| 国产欧美日韩国产高清| 中文国产成人精品久久久| 色诱视频在线观看| 国产高潮国产高潮久久久| 亚洲色婷婷婷婷五月基地| 国产精品无码一区二区在线看| 婷婷丁香五月中文字幕| 成人亚洲精品久久久久| 国产内射在线激情一区| 久久久久免费看黄a片app| 99久久国产宗和精品1上映| 午夜私人成年影院在线观看| 人妻熟女一区二区aⅴ清水理纱 | 狠狠噜天天噜日日噜视频麻豆| 日本人妻丰满熟妇久久久久久| 精品亚洲国产成人av在线时间短的| 激情国产av做激情国产爱| 女人高潮内射99精品| 亚洲中文在线播放一区|