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  4. Recombinant Mouse Regulator of G-protein signaling 9-binding protein (Rgs9bp), partial

Recombinant Mouse Regulator of G-protein signaling 9-binding protein (Rgs9bp), partial

  • 中文名稱：
    小鼠Rgs9bp重組蛋白
  • 貨號：
    CSB-YP619900MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Rgs9bp重組蛋白
  • 貨號：
    CSB-EP619900MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Rgs9bp重組蛋白
  • 貨號：
    CSB-EP619900MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Rgs9bp重組蛋白
  • 貨號：
    CSB-BP619900MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Rgs9bp重組蛋白
  • 貨號：
    CSB-MP619900MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Rgs9bp
  • Uniprot No.：
  • 別名：
    Rgs9bp; R9ap; Regulator of G-protein signaling 9-binding protein; RGS9-anchoring protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation.
  • 基因功能參考文獻(xiàn)：
    1. R9AP is actively targeted in rods by its SNARE homology domain. PMID: 25009288
    2. the presence of a second, R9AP-expressing transgene in the iCre75 mouse line, leading to altered kinetics of phototransduction. PMID: 24526444
    3. Under dim-light conditions vision is unaffected in transgenic mice overexpressing R9AP in rod photoreceptors. PMID: 23055507
    4. Data report a surprising observation that the knockout of RGS9 causes a delay in ERG b-wave responses essentially identical to that observed in the R9AP knockout. PMID: 22096596
    5. This study indicated that R9AP is required for stable expression of RGS11-Gbeta5 in ON-bipolar cell dendrites. PMID: 20100392
    6. photoreceptors R9AP determines the stability of the RGS9.Gbeta5 complex, and therefore all three proteins, RGS9, Gbeta5 , and R9AP, are obligate members of the regulatory complex that speeds the rate at which transducin hydrolyzes GTP. PMID: 14625292

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type IV membrane protein.
  • 蛋白家族：
    RGS7BP/RGS9BP family
  • 組織特異性：
    Predominantly expressed in photoreceptors of the retina. Weakly expressed in other areas of the central nervous system.
  • 數(shù)據(jù)庫鏈接：


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