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  4. Recombinant Mouse Regulator of G-protein signaling 10 (Rgs10)

Recombinant Mouse Regulator of G-protein signaling 10 (Rgs10)

  • 中文名稱：
    小鼠Rgs10重組蛋白
  • 貨號：
    CSB-YP019642MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Rgs10重組蛋白
  • 貨號：
    CSB-EP019642MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Rgs10重組蛋白
  • 貨號：
    CSB-EP019642MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Rgs10重組蛋白
  • 貨號：
    CSB-BP019642MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Rgs10重組蛋白
  • 貨號：
    CSB-MP019642MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Rgs10
  • Uniprot No.：
  • 別名：
    Rgs10; Regulator of G-protein signaling 10; RGS10
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-181
  • 氨基酸序列
    MFTRAVSRLS RKRPPSDIHD GDGSSSSGHQ SLKSTAKWAS SLENLLEDPE GVQRFREFLK KEFSEENVLF WLACEDFKKT EDRKQMQEKA KEIYMTFLSN KASSQVNVEG QSRLTEKILE EPHPLMFQKL QDQIFNLMKY DSYSRFLKSD LFLKPKRTEE EEEEPPDAQT AAKRASRIYN T
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein.
  • 基因功能參考文獻：
    1. Findings suggest a role of regulator of G-protein signalling 10 protein (RGS10) in modulating the hemostatic and thrombotic functions of platelets, and a potential therapeutic target to control platelet activity and/or hypercoagulable states. PMID: 27829061
    2. Rgs10 expression is dynamically regulated in microglia in response to multiple signals. PMID: 28031332
    3. These data demonstrate a critical role for RGS10 in mediating autoimmune disease through regulation of T lymphocyte function. PMID: 26831924
    4. data indicate that Rgs10-/- macrophages displayed dysregulated M1 responses along with blunted M2 alternative activation responses PMID: 24278459
    5. we identified protein kinase A and the downstream phospho-cAMP response element-binding signaling pathway as key mediators of the neuroprotective effect of RGS10 against inflammatory stress PMID: 22564151
    6. RGS10 negatively regulates nuclear factor kappaB activation and production pathway in microglia and demonstrates the neuroprotective effects of microglial RGS10 gene transfer in a rat model of parkinsonism. PMID: 21849548
    7. mechanism through which RGS10 specifically regulates the RANKL-evoked RGS10/calmodulin-[Ca2+]i oscillation-calcineurin-NFATc1 signaling pathway in osteoclast differentiation PMID: 17626792
    8. Results demonstrate the specificity of RGS10A as a key component in the RANKL-evoked signaling pathway for osteoclast differentiation. PMID: 17881498
    9. Limits microglial-derived TNF secretion and regulates functional outcome of inflammatory stimuli in tventral midbrain. Novel drug target for prevention of nigrostriatal pathway degeneration, neuropathological hallmark of Parkinson's disease. PMID: 18716210

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  • 亞細胞定位：
    Cytoplasm, cytosol. Nucleus.
  • 數據庫鏈接：


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