在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Rab5 GDP/GTP exchange factor (Rabgef1)

Recombinant Mouse Rab5 GDP/GTP exchange factor (Rabgef1)

  • 中文名稱：
    小鼠Rabgef1重組蛋白
  • 貨號：
    CSB-YP864373MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Rabgef1重組蛋白
  • 貨號：
    CSB-EP864373MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Rabgef1重組蛋白
  • 貨號：
    CSB-EP864373MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Rabgef1重組蛋白
  • 貨號：
    CSB-BP864373MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Rabgef1重組蛋白
  • 貨號：
    CSB-MP864373MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Rabgef1
  • Uniprot No.：
  • 別名：
    Rabgef1; Rabex5; Rab5 GDP/GTP exchange factor; Rabex-5
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-491
  • 氨基酸序列
    MSLKSERRGI HVDQSELLCK KGCGYYGNPA WQGFCSKCWR EEYHKARQRQ IQEDWELAER LQREEEEAFA SSQSSQGAQS LTFSKFEEKK TNEKTRKVTT VKKFFSASSR AGSKKEIQEA KAPSPSINRQ TSIETDRVTK EFIDFLKTFH KTGQEVYKQT KMFLEAMPYK RDLSIEEQSE CTQDFYQNVA ERMQTRGKVP PEKVEKIMDQ IEKHIMTRLY KFVFCPETTD DEKKDLAIQK RIRALHWVTP QMLCVPVNEE IPEVSDMVVK AITDIIEMDS KRVPRDKLAC ITRCSKHIFN AIKITKNEPA SADDFLPTLI YIVLKGNPPR LQSNIQYITR FCNPSRLMTG EDGYYFTNLC CAVAFIEKLD AQSLNLSQED FDRYMSGQTS PRKQESESWP PEACLGVKQM YKNLDLLSQL NERQERIMNE AKKLEKDLID WTDGIAKEVQ DIVEKYPLEI KPPNQPLAAI DSENVENDKL PPPLQPQVYA G
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.
  • 基因功能參考文獻：
    1. AP-1/sigma1A-ArfGAP1-Rabex-5 complex formation leads to more endosomal Rabex-5 and enhanced, Rab5(GTP)-stimulated Vps34 PI3-kinase activity, which is essential for multivesicular body endosome formation. PMID: 27411398
    2. findings reveal a key role for RABGEF1 in dampening keratinocyte-intrinsic MYD88 signaling and sustaining epidermal barrier function PMID: 27820702
    3. Knockdown of RABEX-5 also inhibited wound healing, migration and the invasive abilities of gastric cancer cells. PMID: 25427001
    4. Kruppel-like factor 5 is indispensable for adhesion, homing, lodging and retention of haematopoietic stem cells and progenitors in the bone marrow through Rab5-dependent post-translational regulation of beta1/beta2 integrins PMID: 23552075
    5. Rab5 is required for phagocytosis of heat-inactivated Pseudomonas aeruginosa by macrophages. PMID: 23630954
    6. a novel mechanistic insight into how Rabex-5 regulates internalization and postendocytic trafficking of ubiquitinated L1 destined for lysosomal degradation. PMID: 22846990
    7. Data report the identification of Rab22 as a binding site on early endosomes for direct recruitment of Rabex-5 and activation of Rab5, establishing a Rab22-Rab5 signaling relay to promote early endosome fusion. PMID: 19759177
    8. RabGEF1 is a negative regulator of Fc epsilon RI-dependent mast cell activation, and a lack of RabGEF1 results in the development of skin inflammation in vivo. PMID: 15235600
    9. p85alpha protein may play a role in the down-regulation of activated receptors through its temporal control of the GTPase cycles of Rab5 and Rab4 PMID: 15377662
    10. RabGEF1 plays a critical role in the regulation of SCF/c-Kit-mediated signaling events and biological responses in mast cells. PMID: 16533754
    11. Data show that RabGEF1 is a negative regulator of Ras signalling and FcepsilonRI-dependent mast cell activation in vitro, and a lack of RabGEF1 results in the development of elevated numbers of mast cells in the skin and severe skin inflammation in vivo. PMID: 16605131
    12. Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5. PMID: 16880210
    13. Our data demonstrate that TeNT H(C) uses a retrograde transport pathway shared with p75(NTR), TrkB, and BDNF, which is strictly dependent on the activities of both Rab5 and Rab7 PMID: 17046692

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Early endosome. Recycling endosome.
  • 組織特異性：
    Expressed in the white matter tracts of the cerebellum, the fimbria hippocampi and the corpus callosum.
  • 數據庫鏈接：


主站蜘蛛池模板： 久久精品国产99久久久| 国产精品久久久久久无码五月| 国产毛片不卡野外视频| 中文字幕在线不卡精品视频99 | 亚洲中文无码人a∨在线导航| 欧美人与善在线com| 亚洲精品一区久久久久| 亚洲色偷拍另类无码专区| 久久久国产精华液| 成人做爰高潮片免费视频| 真人床震高潮全部视频免费 | 国产熟睡乱子伦午夜视频| 国产精品白浆在线观看免费| 麻豆人妻无码性色av专区| 精品一区二区三区在线视频| а天堂8中文最新版在线官网| 久久久久成人片免费观看r| 精品国产一区二区三区av色诱| 国产又黄又大又粗视频| 中文字幕乱码免费看电影| 另类亚洲综合区图片区小说| 国产乱人伦av在线a最新| 亚洲欭美日韩颜射在线二| 色偷一区国产精品| 九色精品国产成人综合网站| 伊人久久精品无码av一区| 朝鲜美女黑毛bbw| 午夜私人成年影院| yy111111少妇影院无码| 精品国产第一国产综合精品| 人妻换人妻仑乱| 少妇人妻中文字幕hd| 亚洲精品久久久久久中文| 婷婷亚洲久悠悠色悠在线播放| 亚洲高清国产av拍精品青青草原 | 色综合久久精品亚洲国产| 久久亚洲人成综合网| 国产裸体歌舞一区二区| 少妇系列之白嫩人妻| 亚洲国产精品无码中文字满| 婷婷色怡春院|