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  4. Recombinant Mouse Protein scribble homolog (Scrib), partial

Recombinant Mouse Protein scribble homolog (Scrib), partial

  • 中文名稱：
    小鼠Scrib重組蛋白
  • 貨號：
    CSB-YP772136MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Scrib重組蛋白
  • 貨號：
    CSB-EP772136MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Scrib重組蛋白
  • 貨號：
    CSB-EP772136MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Scrib重組蛋白
  • 貨號：
    CSB-BP772136MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Scrib重組蛋白
  • 貨號：
    CSB-MP772136MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Scrib; Kiaa0147; Lap4; Scrib1; Protein scribble homolog; Scribble; Protein LAP4
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization. Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting of synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.
  • 基因功能參考文獻：
    1. Scribdeficient hematopoietic stem cells reveal impaired migratory capacity. PMID: 30083817
    2. Results identify a key planar cell polarity (PCP) protein, Scrib, as one of the fundamental scaffold proteins that enable hippocampal glutamatergic synapses to mature and to express bidirectional plasticity required for memory formation. Study offers a unique insight into the mechanism by which the PCP protein Scrib can regulate memory formation at postnatal stages. PMID: 28968740
    3. In the Scrib mutant, despite severe neural tube defects, epF and preBotC neurons settled at their expected hindbrain positions. Furthermore, both networks remained capable of generating rhythmically organized, respiratory-related activities and exhibited normal sensitivity to pharmacological agents known to modify respiratory circuit function. PMID: 28583412
    4. SCRIB is a positive regulator of mammary epithelial cell proliferation during pregnancy. PMID: 27179074
    5. Suggest a role for Plexin-B1 as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A regulating cell migration via Scrib. PMID: 28007914
    6. SCRIB uncouples reactive oxygen species-dependent bacterial killing activity from M1 polarization and inflammatory functions of macrophages PMID: 27694890
    7. we provide genetic evidence of a unique link between skin carcinogenesis and loss of the epithelial polarity regulator Scrib, emphasizing that Scrib exerts a wide-spread tumor suppressive function in epithelia. PMID: 26376988
    8. The polarity protein Scribble regulates myelination and remyelination in the central nervous system. PMID: 25807062
    9. Scrib is a regulator of tissue stem cells, controlling population expansion and self-renewal with Scrib expression dynamics directing satellite cell fate. PMID: 25704816
    10. Scrib is a novel proinflammatory regulator in endothelial cells, which maintains the protein expression of GATA-like protein-1. PMID: 26205961
    11. The Scrib-Rac1 interaction plays a crucial role in the organization of developing cardiomyocytes and formation of the ventricular myocardium. PMID: 25139745
    12. We show that loss of Scrib and activated oncogenic KRas cooperate in vivo, resulting in more aggressive lung tumors PMID: 24276238
    13. findings, based on a definitive genetic mouse model provide fundamental insights into mammary duct maturation and homeostasis and reveal that Scrib loss activates a MAPK/Fra1 pathway that alters mammary progenitor activity PMID: 24852022
    14. The Scribble knockout fetus exhibits exomphalos (intact and ruptured), in contrast to the original published phenotype of gastroschisis. PMID: 24094954
    15. Scrib is required to maintain epithelial identity and that loss of Scrib can culminate in EMT, mediated, at least in part, through TGFbeta signaling. PMID: 24095903
    16. B cell differentiation does not require polarity proteins of the Scribble complex, and the findings do not support a role for asymmetric cell division in B cell activation and differentiation. PMID: 23653213
    17. Scrib is required for normal lung epithelial organisation and lumen morphogenesis by maintaining cell-cell contacts. PMID: 23195221
    18. while Scribble seems to be important for general epithelial cell and pronephros development, it appears to be dispensable for podocyte function and development PMID: 22586490
    19. Mutation in the planar cell polarity gene, Scrib, and a mutation in caspase-3 gene have the most profound effect in controlling neural development. PMID: 21515572
    20. Scrib is indispensable for prostate homeostasis. Scrib heterozygosity initiated prostate hyperplasia, while targeted biallelic Scrib loss predisposed mice to prostate intraepithelial neoplasia. PMID: 21965329
    21. the phosphorylation state of Scribble regulates its complex formation with the E-cadherin-catenin system and may control cadherin-mediated cell-cell adhesion. PMID: 21146521
    22. Immature T-cell clustering and efficient differentiation require the polarity protein Scribble. PMID: 21189299
    23. Our data identify Scrib1 as a crucial regulator of brain development and spine morphology. PMID: 20660256
    24. Heterozygotes are incompletely penetrant for a circled-tail phenotype, while homozygotes die at birth of a severe neural tube defect. PMID: 12112872
    25. Scrb1, encodes a member of the LAP protein family related to Drosophila scribble.Disruption of scribble (Scrb1) gene causes severe neural tube defects in the circletail mouse PMID: 12499390
    26. mutation in Scrb1 results in disruptions in the polarization of stereociliary bundles in mouse cochlea due to defects in the direction of movement and/or anchoring of the kinocilium within each hair cell PMID: 12724779
    27. The observed localization of Dlg-1 and Scrib with cadherins suggests that these proteins may play roles in cell adhesion, polarity and proliferation, as they do in invertebrates, suggesting cross-species conservation of function for these PDZ proteins. PMID: 16402019
    28. data underscore the role of Scrib in cell migration and show the strong impact of Scrib in the function of PAK and Rac, two key molecules implicated in this process PMID: 18716323
    29. Study demonstrates that scribble inhibits breast cancer formation and that deregulation of polarity pathways promotes dysplastic and neoplastic growth in mammals by disrupting morphogenesis and inhibiting cell death. PMID: 19041750
    30. This is the first study to demonstrate the involvement of Dlg1, Scrib, and Lgl1 in a mouse with ocular adenocarcinoma and the simultaneous involvement of these proteins in the same cancer. PMID: 19098995
    31. Scribble functions downstream of beta-catenin to cluster synaptic vesicles at developing synapses. PMID: 19458197

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  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein. Cell junction. Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Cell junction, synapse, postsynapse. Cell junction, synapse, presynapse.
  • 蛋白家族：
    LAP (LRR and PDZ) protein family
  • 組織特異性：
    Expressed in CD4+ T-cells (at protein level). Found in a wide range of tissues including liver, kidney and spleen. Also expressed in the brain (at protein level).
  • 數據庫鏈接：


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