在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Protein salvador homolog 1 (Sav1)

  • 中文名稱:
    小鼠Sav1重組蛋白
  • 貨號:
    CSB-YP851839MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Sav1重組蛋白
  • 貨號:
    CSB-EP851839MO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小鼠Sav1重組蛋白
  • 貨號:
    CSB-EP851839MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Sav1重組蛋白
  • 貨號:
    CSB-BP851839MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Sav1重組蛋白
  • 貨號:
    CSB-MP851839MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Sav1; Ww45; Wwp3; Protein salvador homolog 1; 45 kDa WW domain protein; mWW45
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-386
  • 氨基酸序列
    MLSRKKTKNE VSKPAEVQGK YVKKETSPLL RNLMPSFIRH GPTIPRRTDL CLPDSSATAF SASGDGVVSR NQSFLRTAIQ RTPHEVMRRE SHRLSAPSYL VRSLADVPRE CGSSQSFLTE VNFAVENGDS GSRYFFSDNF FDGQRRRPLG DRAQEDYRYY EYNHDLFQRM PQSQGRHTSG IGRVTATSLG NLTNHGSEDL PLPPGWSVDW TMRGRKYYID HNTNTTHWSH PLEREGLPPG WERVESSEFG TYYVDHTNKR AQYRHPCAPS VPRYDQPPPI TYQPQQTERN QSLLVPANPY HTAEIPDWLQ VYARAPVKYD HILKWELFQL ADLDTYQGML KLLFMKELEQ IVKLYEAYRQ ALLTELENRK QRQQWYAQQH GKTFLS
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
  • 基因功能參考文獻:
    1. deletion of the Hippo pathway component Salvador (Salv) in mouse hearts with established ischaemic heart failure after myocardial infarction induces a reparative genetic program with increased scar border vascularity, reduced fibrosis, and recovery of pumping function compared with controls PMID: 28976966
    2. In this study, they investigated epigenetic characteristics of WW45+/- mice, evaluating time-dependent changes from prior to the onset of tumorigenesis to hepatocarcinoma. PMID: 21163252
    3. show that mice with liver-specific ablation of WW45 (a homolog of Drosophila Salvador and adaptor for the Hippo kinase) manifest increased liver size and expansion of hepatic progenitor cells (oval cells) and eventually develop hepatomas. PMID: 20404163
    4. While typical WW domains function as monomeric modules that recognize proline-rich sequences, by using conserved residues that are solvent-exposed on the surface of the beta-sheet, this WW domain buries these residues in the dimer interface. PMID: 17239860
    5. Mice lacking WW45 reveal a crucial role for WW45 in cell-cycle exit and epithelial terminal differentiation. PMID: 18369314

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 組織特異性:
    Ubiquitously expressed in adult tissues with the highest level found in testis.
  • 數據庫鏈接:


主站蜘蛛池模板: 国产福利自产拍| 四虎影视在线影院在线观看| 色综合天天综合高清网国产在线| 人妻.中文字幕无码| 少妇久久久久久人妻无码| 99久久人人爽亚洲精品美女| 精品无码无人网站免费视频 | 国产一精品一av一免费| 国产欧美日韩| 日本亚洲欧美高清专区vr专区| 蜜桃少妇av久久久久久久| 国产佗精品一区二区三区| 久久久久久久无码高潮| 亚洲综合av一区二区三区不卡| 伊人久久久大香线蕉综合直播| 欧美成人猛片aaaaaaa| 日本人妻人人人澡人人爽| 亚洲男人片片在线观看| 九九视频免费精品视频| 蜜桃av抽搐高潮一区二区 | 亚洲精品无码久久久久| 午夜免费啪视频在线18| 日本一卡二卡3卡四卡网站精品| 亚洲欧美国产精品专区久久| 国产精品无码专区在线观看| 娜娜麻豆国产电影| 久久久无码精品亚洲日韩按摩| 99久久人妻无码精品系列| 国产又黄又爽又色的免费| 欧美饥渴少妇xxxxx性| 国内大量偷窥精品视频| 久久久久久人妻一区精品| 国产精品欧美成人片| 秋霞av鲁丝片一区二区| 国产在线aaa片一区二区99| 欧美激情猛片xxxⅹ大3| 国产亚洲精品第一综合麻豆| 国产亚洲精品美女久久久久| 国产色欲色欱www在线| 国产精品自在在线午夜免费| 波多野结av衣东京热无码专区|