在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Protein mago nashi homolog (Magoh)

Recombinant Mouse Protein mago nashi homolog (Magoh)

  • 中文名稱：
    小鼠Magoh重組蛋白
  • 貨號：
    CSB-YP013364MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Magoh重組蛋白
  • 貨號：
    CSB-EP013364MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Magoh重組蛋白
  • 貨號：
    CSB-EP013364MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Magoh重組蛋白
  • 貨號：
    CSB-BP013364MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Magoh重組蛋白
  • 貨號：
    CSB-MP013364MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Magoh
  • Uniprot No.：
  • 別名：
    Magoh; Protein mago nashi homolog
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-146
  • 氨基酸序列
    MESDFYLRYY VGHKGKFGHE FLEFEFRPDG KLRYANNSNY KNDVMIRKEA YVHKSVMEEL KRIIDDSEIT KEDDALWPPP DRVGRQELEI VIGDEHISFT TSKIGSLIDV NQSKDPEGLR VFYYLVQDLK CLVFSLIGLH FKIKPI
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly.
  • 基因功能參考文獻：
    1. we first show that Eif4a3 haploinsufficiency phenocopies aberrant neurogenesis and microcephaly of Magoh and Rbm8a mutant mice.we show that genetic ablation of one downstream pathway, p53, significantly rescues microcephaly of all 3 EJC mutant PMID: 27618312
    2. findings show 2 genes MAGOH and MAGOHB are expressed in mammals; in macrophages, expression of MAGOHB but not MAGOH mRNA increases after LPS stimulation; both MAGOH proteins interact with other exon junction complex (EJC) components, incorporate into mRNA-bound EJCs and activate nonsense-mediated decay PMID: 23917022
    3. These results point to a central role for Magoh in melanocyte development. PMID: 23333945
    4. mouse magoh is involved in cyclin-dependent kinase regulation. PMID: 21210908
    5. Magoh haploinsufficiency causes microcephaly because of intermediate neural progenitors depletion and neuronal apoptosis. PMID: 20364144

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Nucleus speckle. Cytoplasm.
  • 蛋白家族：
    Mago nashi family
  • 組織特異性：
    Ubiquitous. Detected in brain, heart, liver, lung, spleen and testis.
  • 數據庫鏈接：

    KEGG: mmu:17149

    STRING: 10090.ENSMUSP00000030348

    UniGene: Mm.808



主站蜘蛛池模板： 一个人看的免费视频www中文字幕 手机在线看永久av片免费 | 寂寞少妇做spa按摩无码 | 婷婷色香五月综合缴缴情| 少妇精品视频无码专区| 国产午夜亚洲精品午夜鲁丝片| 中文字幕无码人妻少妇免费| 欧美日激情日韩精品嗯| 亚洲成成熟女人专区| 国产精品成人一区无码| 欧美成人秋霞久久aa片| 一本天堂v无码亚洲道久久| 无码日韩精品一区二区三区免费| 国产成人精品无码免费看夜聊软件| 人妻少妇av无码一区二区| 久久久国产精品va麻豆| 国内老熟妇乱子伦视频| 99久久精品国产一区二区蜜芽| av网站免费线看精品| 男生白内裤自慰gv白袜男同| 国产边打电话边被躁视频| 中文字幕亚洲乱码熟女在线 | 国产日产欧产精品精品app| av中文无码韩国亚洲色偷偷| 18禁成人网站免费观看| 18禁无码永久免费无限制网站| 国产sp调教打屁股视频网站| 国精产品一区二区三区有限公司| 亚洲精品av中文字幕在线| 狠狠色噜噜狠狠狠888777米奇| 熟妇高潮一区二区三区| 国产精品久久久久久爽爽爽| 亚洲高清国产av拍精品青青草原| 亚洲色欲色欲综合网站| 中文国产成人精品久久不卡| 亚洲大乳高潮日本专区| 国产精品久久人妻互换| 精品人妻无码一区二区三区性| 亚洲欧洲成人av每日更新| 亚洲 日韩 国产 有码 不卡| 精品无码久久久久久久久久| 欧美性猛交xxxx乱大交丰满|