在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Protein mago nashi homolog (Magoh)

  • 中文名稱:
    小鼠Magoh重組蛋白
  • 貨號:
    CSB-YP013364MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Magoh重組蛋白
  • 貨號:
    CSB-EP013364MO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小鼠Magoh重組蛋白
  • 貨號:
    CSB-EP013364MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Magoh重組蛋白
  • 貨號:
    CSB-BP013364MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Magoh重組蛋白
  • 貨號:
    CSB-MP013364MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    Magoh
  • Uniprot No.:
  • 別名:
    Magoh; Protein mago nashi homolog
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-146
  • 氨基酸序列
    MESDFYLRYY VGHKGKFGHE FLEFEFRPDG KLRYANNSNY KNDVMIRKEA YVHKSVMEEL KRIIDDSEIT KEDDALWPPP DRVGRQELEI VIGDEHISFT TSKIGSLIDV NQSKDPEGLR VFYYLVQDLK CLVFSLIGLH FKIKPI
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly.
  • 基因功能參考文獻:
    1. we first show that Eif4a3 haploinsufficiency phenocopies aberrant neurogenesis and microcephaly of Magoh and Rbm8a mutant mice.we show that genetic ablation of one downstream pathway, p53, significantly rescues microcephaly of all 3 EJC mutant PMID: 27618312
    2. findings show 2 genes MAGOH and MAGOHB are expressed in mammals; in macrophages, expression of MAGOHB but not MAGOH mRNA increases after LPS stimulation; both MAGOH proteins interact with other exon junction complex (EJC) components, incorporate into mRNA-bound EJCs and activate nonsense-mediated decay PMID: 23917022
    3. These results point to a central role for Magoh in melanocyte development. PMID: 23333945
    4. mouse magoh is involved in cyclin-dependent kinase regulation. PMID: 21210908
    5. Magoh haploinsufficiency causes microcephaly because of intermediate neural progenitors depletion and neuronal apoptosis. PMID: 20364144

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Nucleus speckle. Cytoplasm.
  • 蛋白家族:
    Mago nashi family
  • 組織特異性:
    Ubiquitous. Detected in brain, heart, liver, lung, spleen and testis.
  • 數據庫鏈接:

    KEGG: mmu:17149

    STRING: 10090.ENSMUSP00000030348

    UniGene: Mm.808



主站蜘蛛池模板: 国产精品免费久久久久软件| 99久久人妻精品免费一区| 让少妇高潮无乱码高清在线观看| 国产成人a区在线观看| 精品国产乱码久久久久软件| 国产人妻精品一区二区三区| 无码福利日韩神码福利片| 一本大道东京热无码一区| 印度女人狂野牲交| 亚洲六月丁香六月婷婷| 亚洲国产日韩a在线播放| 欧美xxxxx在线观看| 好紧好爽免费午夜视频| 色综合av男人的天堂伊人| 亚洲国产精品热久久| 国产超碰女人任你爽| 成人国产片视频在线观看| 亚洲欧洲日韩极速播放| 亚洲人成亚洲精品| 欧美疯狂做受xxxx高潮| 亚洲欧美综合在线天堂| 自拍偷自拍亚洲精品第1页| 成人免费无码不卡毛片视频| 9l国产精品久久久久麻豆| 在线日产精品一区| 西西人体44www大胆无码| 最近中文字幕mv在线资源| 久久久久久亚洲精品不卡| 一个添下面两个吃奶把腿扒开| 久久精品人人做人人爱爱漫画| 成年女人片免费视频播放a| 中文无码伦av中文字幕在线| 久久国产成人免费网站777| 日本黄页网站免费观看| 日韩一区二区三区精品| 久久久久久九九99精品| 青草草在线视频永久免费| 免费看又黄又无码的网站 | 少妇被粗大的猛进69视频| 国产女主播白浆在线观看| 国产乱人伦在线播放|