在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Polyphosphoinositide phosphatase (Fig4), partial

Recombinant Mouse Polyphosphoinositide phosphatase (Fig4), partial

  • 中文名稱：
    小鼠Fig4重組蛋白
  • 貨號：
    CSB-YP856303MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Fig4重組蛋白
  • 貨號：
    CSB-EP856303MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Fig4重組蛋白
  • 貨號：
    CSB-EP856303MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Fig4重組蛋白
  • 貨號：
    CSB-BP856303MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Fig4重組蛋白
  • 貨號：
    CSB-MP856303MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Fig4
  • Uniprot No.：
  • 別名：
    Fig4; Kiaa0274; Sac3Polyphosphoinositide phosphatase; EC 3.1.3.-; Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; SAC domain-containing protein 3
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.; Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate. Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production. In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro.
  • 基因功能參考文獻：
    1. Neuronal expression of Fig4(C486S) transgene prevents neonatal neurodegeneration & juvenile lethality seen in Fig4-/- mice. However, later in life Fig4(C486S) causes significant abnormalities: hydrocephalus, defective myelination &reduced lifespan PMID: 26604144
    2. Inactivation of Fig4 in motor neurons display neuronal and axonal degeneration. PMID: 25187576
    3. Fig4 expression in the neurons is both necessary and sufficient to prevent spongiform neurodegeneration PMID: 22581779
    4. Haploinsufficiency of Fig4 does not impose risks in rodents to develop neuronal degeneration in either naive or traumatic conditions. PMID: 21872275
    5. Fig4 may be required to prevent neurons and glia from excessive lysosomal accumulation after injury and in neurodegeneration. PMID: 22157617
    6. Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J PMID: 21655088
    7. Results suggest that Fig4 deficiency affects motor neurons differently from sensory neurons by mechanisms involving excessive retention of molecules in lysosomes or disruption of vacuolated organelles. PMID: 21410794
    8. a novel regulatory mechanism whereby ArPIKfyve enhances Sac3 abundance by attenuating Sac3 proteasome-dependent degradation and suggest that a failure of this mechanism could be the primary molecular defect in the pathogenesis of CMT4J. PMID: 20630877
    9. shd1 is involved in cell cycle progression, in particular centrosome duplication and a spindle assembly checkpoint function. PMID: 15322101
    10. The pale tremor mutant provides the first evidence regarding the functional role of mammalian Fig4 PMID: 17572665
    11. Sac3 as an insulin-sensitive phosphatase whose down-regulation increases insulin responsiveness, thus implicating Sac3 as a novel drug target in insulin resistance. PMID: 19578118

    顯示更多

    收起更多

  • 相關疾病：
    Defects in Fig4 are the cause of the pale tremor phenotype which is a multi-organ disorder with neuronal degeneration in the central nervous system, peripheral neuronopathy and diluted pigmentation. At postnatal day three (P3), affected homozygotes have diluted pigmentation and reduced size. Intentional tremor develops during the second week after birth, and abnormal limb postures are evident by the third week. There is impaired motor coordination, muscle weakness and "swimming" gait. There is progressive loss of mobility, reduction in body weight and juvenile lethality.
  • 亞細胞定位：
    Endosome membrane.
  • 組織特異性：
    Wide-spread.
  • 數據庫鏈接：


主站蜘蛛池模板： 成年免费视频黄网站在线观看| 欧美多毛肥胖老妇做爰| 欧美激情精品久久| 成人做爰视频www网站小优视频 | 国产色播av在线观看| 国产麻豆一精品av一免费软件| 国产精品偷伦视频观看免费| 妓院一钑片免看黄大片| 久久婷婷五月综合色精品| 免费的av网站在线观看国产精品| 怡红院成永久免费人视频新的| 成年女人永久免费观看视频| 天天做天天爱天天综合网 | 国产内射999视频一区| 日日摸夜夜摸狠狠摸婷婷| 奇米影视7777久久精品人人爽| 国产成人精品123区免费视频| 妇女性内射冈站hdwww000| 国产亚洲aⅴ在线电影| 鲁鲁狠狠狠7777一区二区| 亚洲成a人v影院色老汉影院| 国产乱码日产精品bd| 国产欧美日韩亚洲18禁在线| 中文字幕日产熟女乱码| 国产中的精品av一区二区| 制服 丝袜 人妻 专区一本| 亚洲精品色在线网站| 丝袜无码一区二区三区| 18禁无遮挡羞羞污污污污网站| 狠狠躁夜夜躁人人躁婷婷视频| 在线看片免费人成视频久网| 成人电线在线播放无码| 国产精品人妻一区二区高| 朝鲜美女黑毛bbw| 国产av高清无亚洲| 在线视+欧美+亚洲日本| 中国孕妇变态孕交xxxx| 久久精品国产99久久丝袜蜜桃| 国产精品久久人妻互换| 欧美老人巨大xxxx做受| 少妇的丰满3中文字幕|