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  4. Recombinant Mouse Polyhomeotic-like protein 1 (Phc1), partial

Recombinant Mouse Polyhomeotic-like protein 1 (Phc1), partial

  • 中文名稱：
    小鼠Phc1重組蛋白
  • 貨號：
    CSB-YP734077MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Phc1重組蛋白
  • 貨號：
    CSB-EP734077MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Phc1重組蛋白
  • 貨號：
    CSB-EP734077MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Phc1重組蛋白
  • 貨號：
    CSB-BP734077MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Phc1重組蛋白
  • 貨號：
    CSB-MP734077MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Phc1
  • Uniprot No.：
  • 別名：
    Phc1; Edr; Edr1; Rae28; Polyhomeotic-like protein 1; mPH1; Early development regulatory protein 1; RAE-28
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.
  • 基因功能參考文獻：
    1. rae28 has a crucial role in sustaining the activity of hematopoietic stem cells to maintain hematopoiesis PMID: 11901201
    2. Gene rae28 is involved in cardiac morphogenesis through a non cardiomyocyte pathway. However, cardiomyocyte-specific overexpression of rae28 caused dilated cardiomyopathy. PMID: 11950896
    3. The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis. PMID: 12122109
    4. in vivo results clearly indicate that Polycomb-group gene rae28 is indispensable for the long-term repopulating ability of HSCs PMID: 15245505
    5. polymeric Scm complexes could extend beyond the local domains of polymeric Ph complexes on chromatin, possibly playing a role in long range repression PMID: 15905166
    6. functional overlap between Phc2 and Phc1 along with a strict dose-dependent requirement during anterior-posterior (A-P) patterning PMID: 16024804
    7. PcG complex 1, involving Rae28 and Cdt1, supports the activity of hematopoietic stem cells by enhancing cycling capability and hematopoietic activity through direct regulation of Geminin PMID: 18650381

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Highly expressed in testis with lower levels in most other tissues. Expressed in embryonic stem cells.
  • 數據庫鏈接：

    KEGG: mmu:13619

    STRING: 10090.ENSMUSP00000078514

    UniGene: Mm.6822



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