在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Plasminogen activator inhibitor 2, macrophage (Serpinb2)

In Stock
  • 中文名稱:
    Recombinant Mouse Plasminogen activator inhibitor 2, macrophage (Serpinb2)
  • 貨號:
    CSB-EP021070MO
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    PAI-2;Serpin B2
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    53.2 kDa
  • 表達區域:
    1-415aa
  • 氨基酸序列
    MEELSMANTMFALNLLKQIEKSNSTQNIFISPWSISSTLAIVLLGAGGNTEQQMAKVLQFNEIGSYGITTRNPENFSGCDFAQQIQKENYPSAILQAQAGDKIHSAFSSLSSTINTPQGDYLLESANKLFGEKSARFKEEYIQLSKKYYSTEPEAVDFLECAEEAREKINSWVKTQTKGEIPNLLPEGSVDEDTKMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSHESIPVQMMFLHAKLNIGYIKDLKTQILELPHTGNISMLLLLPDEIEDASTGLELLESEINFANFNKWISKDTLDEDDVVVYIPKFKLAQSYELKSILQSMGMEDAFNKGKANFSGMSERNDLFLSEVFHQASVDVTEEGTVAAGGTGAVMTGRTGHGGPQFVADHPFLFFIMDKITHTILFVGRFSSP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival.
  • 基因功能參考文獻:
    1. This study establishes a novel role for SerpinB2 in the stromal compartment in pancreatic ductal adenocarcinoma invasion through regulation of stromal remodelling PMID: 28346421
    2. Data suggest that the function of keratinocyte SerpinB2 is protection of the stratum corneum from proteolysis via inhibition of urokinase, thereby maintaining the integrity and barrier function of the stratum corneum, particularly during times of skin inflammation PMID: 27109612
    3. SerpinB2 plays an important role in proteostas PMID: 26083412
    4. PAI-2 is a novel regulator of venous thrombus resolution, which modulates several pathways involving both inflammatory and uPA activity mechanisms, distinct from PAI-1 PMID: 25041188
    5. SerpinB2 has previously been implicated as a mediator of DMBA/TPA-induced skin carcinogenesis PMID: 25489104
    6. The presence of SerpinB2 on the surface of MPs provides a physiological mechanism whereby cancer cell SerpinB2 can reach the extracellular milieu and access urokinase plasminogen activator (uPA). PMID: 24644264
    7. Brain metastatic cells from lung cancer and breast cancer express high levels of anti-plasminogen activator (PA) serpins, including neuroserpin and serpin B2, to prevent plasmin generation and its metastasis-suppressive effects. PMID: 24581498
    8. C/EBP-beta mediates both constitutive and LPS-induced serpinB2 mRNA expression in mouse embryonic fibroblasts and inflammatory primary macrophages. PMID: 23472114
    9. Depletion PAI-2 resulted in NLRP3- and ASC-dependent caspase-1 activation and IL-1beta secretion in macrophages upon Toll-like receptor 2 (TLR2) and TLR4 engagement. PMID: 24043792
    10. SerpinB2 can be induced by lentiviral infection in vivo. PMID: 23460840
    11. immune regulation of SerpinB2 expression plays a critical role in the development of Th2-mediated protective immunity against nematode infection by a mechanism involving CCL2 production and macrophage infiltration. PMID: 23630350
    12. PAI-2 and TG2 are downstream mediators in the antiapoptotic response triggered upon TBK1 activation. PMID: 22203995
    13. Data show that regulation of Th1 responses thus appears to be a physiological function of inflammation-associated SerpinB2. PMID: 20130210
    14. during differentiation of epidermal keratinocyte, PAI-2 expresses mainly in the more differentiated keratinocytes and may protect the terminal differentiated keratinocytes from prematuration through inhibiting involucrin expression in cornified envelope PMID: 15050365
    15. PAI-2 promotes adipose tissue development in mice via a mechanism independent of its antifibrinolytic effect PMID: 17958744
    16. SerpinB2 is a cell survival factor that modulates Rb repression of proapoptotic signal transduction PMID: 18632617
    17. Plasminogen activator inhibitor-2, but not cystatin C, inhibits the prometastatic activity of tissue inhibitor of metalloproteinases-1 in the liver.( PMID: 18681831

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Secreted, extracellular space.
  • 蛋白家族:
    Serpin family, Ov-serpin subfamily
  • 數據庫鏈接:


主站蜘蛛池模板: 亚洲欧美一区二区成人片| 亚洲精品久久久久久动漫| 久久综合久久爱久久综合伊人| 曰韩a∨无码一区二区三区| 国产69精品久久久久乱码韩国| 亚洲情综合五月天| 荡女精品导航| 欧美激情一区二区成人| 无码人妻少妇精品无码专区漫画 | 久久天天躁夜夜躁狠狠躁2022| 亚洲狠狠成人网| 999久久久精品国产消防器材| 亚洲精品国偷拍自产在线麻豆| 人妻少妇精品中文字幕av| 国产成人精品午夜福利在线观看| 欧美性猛交xxxxx按摩欧美| 国产三级精品三级在线观看| 国产精品久久久久野外| 性夜影院午夜看片| 青青草在在观免费福利线观看| 少妇粉嫩小泬白浆流出| 好吊妞无缓冲视频观看| 国产精品色拉拉| 国产日产欧产精品品不卡| 成年美女黄网站色大免费视频| 色欲av无码一区二区三区| 成 人 a v免费视频在线观看| 手机国产乱子伦精品视频| 亚洲精品字幕在线观看| 久久精品国产精品国产一区| 国产成人a无码短视频| .精品久久久麻豆国产精品| 曰本丰满熟妇xxxx性| 999久久久无码国产精品| 国产成人a区在线观看视频| 狠狠综合久久av一区二区| 国产av久久人人澡人人爱| 精品无码乱码av| 丰满人妻被黑人猛烈进入| 亚洲国产精品国语在线| 最新在线精品国产福利|