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  4. Recombinant Mouse Partitioning defective 3 homolog (Pard3), partial

Recombinant Mouse Partitioning defective 3 homolog (Pard3), partial

  • 中文名稱：
    小鼠Pard3重組蛋白
  • 貨號：
    CSB-YP859998MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Pard3重組蛋白
  • 貨號：
    CSB-EP859998MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Pard3重組蛋白
  • 貨號：
    CSB-EP859998MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Pard3重組蛋白
  • 貨號：
    CSB-BP859998MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Pard3重組蛋白
  • 貨號：
    CSB-MP859998MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Pard3; Par3Partitioning defective 3 homolog; PAR-3; PARD-3; Atypical PKC isotype-specific-interacting protein; ASIP; Ephrin-interacting protein; PHIP
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons. Involved in Schwann cell peripheral myelination.
  • 基因功能參考文獻：
    1. radial glial progenitor behavior and cortical development are controlled by temporally distinct actions of partitioning-defective 3 (PARD3) in concert with dynamic HIPPO signaling PMID: 29899142
    2. Par3A function is either dispensable for slit diaphragm integrity, or compensatory mechanisms and a high redundancy of the different polarity proteins PMID: 27122542
    3. Par-3 plays an important role in the modulation of intestinal barrier function by regulating delivery of occludin as well as suppression of MLC phosphorylation. PMID: 25820151
    4. HTT is required for the apical localization of PAR3-aPKC during epithelial morphogenesis in virgin, pregnant, and lactating mice. PMID: 25942483
    5. Par3 (and protein kinase C zeta) are activated in neurons when binding to N2-proteoglygan. PMID: 23392682
    6. Suggest that loss of Par3 promotes metastatic behaviour of ErbB2-induced breast tumour epithelial cells by decreasing cell-cell cohesion. PMID: 23263278
    7. Par3 is identified as a regulator of signaling pathways relevant to invasive breast cancer. PMID: 23153534
    8. The nucleus of a myoblast moves rapidly after fusion towards the central myotube nuclei which is driven by microtubules and dynein/dynactin complex, and requires Cdc42, Par6 and Par3. PMID: 22732842
    9. Data suggest that aPKC phosphorylates JAM-A at S285 to regulate cell-cell contact maturation, TJ formation, and single lumen specification. PMID: 22371556
    10. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein. PMID: 22128191
    11. Report a willin(FRMD6)/Par3-aPKC-ROCK pathway that controls epithelial apical morphology. PMID: 21685893
    12. findings define a Siah-Pard3A signaling pathway that controls adhesion-dependent exit of neuronal progenitors or immature neurons from a germinal zone niche PMID: 21109632
    13. Disturbance in the interaction between ASPP2 and PAR-3 causes defects in cell polarity. PMID: 20619648
    14. Combined, our findings demonstrate that beta1 integrin functions upstream of Par3 as part of a molecular cascade required for endothelial cell polarity and lumen formation. PMID: 20152176
    15. ASIP plays an important role in neural cell differentiation by means of asymmetric cell division PMID: 12203721
    16. This cell polarity protein binds to the cell-cell adhesion molecule nectin at the tight junction of the neuroepithelial cells of the developing mouse PMID: 12515806
    17. preliminary characterization of it's interaction with Smad3 PMID: 12650946
    18. the CR1-mediated self-association of the PAR-3-containing protein complex plays a role during the formation of functional tight junctions. PMID: 12756256
    19. The natural spatial allocation of blastomere progeny can be over-ridden by downregulation of Par3, leading to a deceased tendency for them to remain outside and so develop into trophectoderm. PMID: 15657073
    20. Results suggest a role for PAR-3 in establishing asymmetry in the egg and in defining the future site of polar body emission. PMID: 15766746
    21. Par3, in conjunction with Tiam1, controls "front-rear" polarity during the persistent migration of freely migrating keratinocytes. PMID: 17825562
    22. In the Ra175(-/-) elongating spermatid, Par-3 was absent, and Jam-C was absent or abnormally localized. PMID: 18055550
    23. Neph1-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity PMID: 18562307
    24. Par-3 functions as a scaffold, coordinating both serine/threonine kinases and the PP1alpha phosphatase PMID: 18641122
    25. The aPKC-PAR3 complex associates with the nephrin-podocin complex in podocytes through direct interaction between PAR3 and nephrin, and the kinase activity of aPKC is required for the appropriate distribution of nephrin and podocin in podocytes. PMID: 19142224
    26. Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells. PMID: 19401335
    27. Results suggest that Par3 acts as a cortical factor that tethers microtubules through its association with LIC2 dynein. PMID: 19540120
    28. Mammalian partition defective protein 3 (mPar3), a key cell polarity determinant, exhibits dynamic distribution in radial glial progenitors. PMID: 19640478

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  • 亞細胞定位：
    Cytoplasm. Endomembrane system. Cell junction. Cell junction, tight junction. Cell junction, adherens junction. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane.
  • 蛋白家族：
    PAR3 family
  • 組織特異性：
    All isoforms are expressed in heart, while expression in brain is mainly limited to isoform 1, and to isoform 3 to a weaker level.
  • 數據庫鏈接：


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