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  4. Recombinant Mouse Nucleoredoxin-like protein 1 (Nxnl1)

Recombinant Mouse Nucleoredoxin-like protein 1 (Nxnl1)

  • 中文名稱：
    小鼠Nxnl1重組蛋白
  • 貨號：
    CSB-YP819735MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Nxnl1重組蛋白
  • 貨號：
    CSB-EP819735MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Nxnl1重組蛋白
  • 貨號：
    CSB-EP819735MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Nxnl1重組蛋白
  • 貨號：
    CSB-BP819735MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Nxnl1重組蛋白
  • 貨號：
    CSB-MP819735MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Nxnl1
  • Uniprot No.：
  • 別名：
    Nxnl1; Rdcvf; Txnl6; Nucleoredoxin-like protein 1; Rod-derived cone viability factor; RdCVF; Thioredoxin-like protein 6
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-217
  • 氨基酸序列
    MASLFSGRIL IRNNSDQDEV ETEAELSRRL ENRLVLLFFG AGACPQCQAF APVLKDFFVR LTDEFYVLRA AQLALVYVSQ DPTEEQQDLF LRDMPEKWLF LPFHDELRRD LGRQFSVRQL PAVVVLKPGG DVLTSDATEE IQRLGPACFA NWQEAAELLD RSFLQPEDLD EPARRSITEP LRRRKYRVDR DVGRERGRNG RDSGDPQGDA GTRAELW
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays an important role in retinal cone photoreceptor survival. In association with glucose transporter SLC16A1/GLUT1 and BSG, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors. May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods.
  • 基因功能參考文獻：
    1. RdCVFL is a cell-autonomous mechanism of protection. PMID: 27025156
    2. Study shows that RdCVF acts through binding to Basigin-1 (BSG1), a transmembrane protein expressed specifically by photoreceptors. BSG1 binds to the glucose transporter GLUT1, resulting in increased glucose entry into cones. PMID: 25957687
    3. The Nxnl1 gene, through the thioredoxin RdCVF-long isoform, is part of an endogenous defense mechanism against photooxidative stress. PMID: 25596499
    4. The RdCVF gene has an essential role in photoreceptor maintenance and resistance to retinal oxidative stress. PMID: 20139892
    5. CHX10 regulates RdCVF promoter activity in the inner retina. PMID: 19843539
    6. functional interaction between RdCVFL and TAU described here is the first characterization of the RdCVFL signaling pathway involved in neuronal cell death mediated by oxidative stress PMID: 19279044

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  • 亞細胞定位：
    Cell projection, cilium, photoreceptor outer segment.
  • 蛋白家族：
    Nucleoredoxin family
  • 組織特異性：
    Expressed in the retina (at protein level). Expressed predominantly by photoreceptors in both the inner and outer nuclear layer (at protein level). Not expressed in the testis, spleen, intestine, lung, cerebellum, or kidney.
  • 數據庫鏈接：


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