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  4. Recombinant Mouse Nuclear-interacting partner of ALK (Zc3hc1)

Recombinant Mouse Nuclear-interacting partner of ALK (Zc3hc1)

  • 中文名稱：
    小鼠Zc3hc1重組蛋白
  • 貨號：
    CSB-YP802257MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Zc3hc1重組蛋白
  • 貨號：
    CSB-EP802257MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Zc3hc1重組蛋白
  • 貨號：
    CSB-EP802257MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Zc3hc1重組蛋白
  • 貨號：
    CSB-BP802257MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Zc3hc1重組蛋白
  • 貨號：
    CSB-MP802257MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Zc3hc1
  • Uniprot No.：
  • 別名：
    Zc3hc1; Nipa; Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; mNIPA; Zinc finger C3HC-type protein 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    2-501
  • 氨基酸序列
    AATSEGPLF AASIEKTWGS VVRSPEGTPQ KVRELIDEGI VPEEGGTEPK DTAATFQSVD GSPQAEQSPL ESTSKEAFFH RVETFSSLKW AGKPPELSPL ICAKYGWVTV ECDMLKCSSC QAFLCASLQP TFDFGRYKER CAELKKSLCS AHEKFCFWPD SPSPDRFGML PLGEPAVLIS EFLDRFQSLC HLDLQLPSLR PEDLKTMCLT EDAVSALLHL LEDELDFHAD DRKTTSKLGS DVQVQATACV LSLCGWACSS LEPTQLSLIT CYQCMRKVGL WGFQQIESSM TDLEASFGLT SSPIPGVEGR PEHFPLVPES PRRMMTRSQD ATVSPGSEQS EKSPGPIVSR TRSWESSSPV DRPELEAASP TTRSRPVTRS MGTGDSAGVE VPSSPLRRTK RARLCSSSSS DTSPRSFFDP TSQHRDWCPW VNITLVKETK ENGETEVDAC TPAEPGWKAV LTILLAHKRS NQPAETDSMS LSEKSRKVFR IFRQWESSSS S
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. Overexpression may be able to protect from apoptosis induced by IL-3 withdrawal.
  • 基因功能參考文獻：
    1. Data show that cell cycle-dependent phosphorylation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA)is mediated by extracellular signal-regulated kinase 2 (ERK2). PMID: 22955283
    2. Results reveal a novel role for NIPA in meiosis. PMID: 22696294
    3. phosphorylated NIPA is degraded in late mitosis in an APC/C(Cdh1)-dependent manner PMID: 22205987
    4. NIPA has an antiapoptotic role in NPM-ALK-mediated signaling events PMID: 12748172
  • 亞細胞定位：
    Nucleus.
  • 數(shù)據(jù)庫鏈接：


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