在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Nischarin (Nisch), partial

Recombinant Mouse Nischarin (Nisch), partial

  • 中文名稱：
    小鼠Nisch重組蛋白
  • 貨號：
    CSB-YP015821MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Nisch重組蛋白
  • 貨號：
    CSB-EP015821MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Nisch重組蛋白
  • 貨號：
    CSB-BP015821MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Nisch重組蛋白
  • 貨號：
    CSB-MP015821MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Nisch
  • Uniprot No.：
  • 別名：
    Nisch; Kiaa0975; Nischarin; Imidazoline receptor 1; I-1; IR1; Imidazoline receptor I-1-like protein; Imidazoline-1 receptor; I1R
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension. Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons. Acts as a modulator of Rac-regulated signal transduction pathways. Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity. Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation. Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation. Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells. Inhibits lamellipodia formation, when overexpressed. Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.
  • 基因功能參考文獻：
    1. results indicate that Nisch is an important AMPK inhibitor and a critical regulator of energy homeostasis, including lipid and glucose metabolism. PMID: 28842496
    2. We identified a significant genetic interaction between Nisch and Itga5; mice heterozygous for Itga5-null and homozygous for edison mutations display a significantly increased penetrance and severity of chronic otitis media. PMID: 28806779
    3. Nischarin inhibits neurite outgrowth by blocking PAK1 activation in neurons. PMID: 26670864
    4. Data from studies using various receptor antagonists/agonists suggest that imidazoline receptors (Nisch I-1), alpha2-adrenoceptors, and endothelin-A receptors are involved in body temperature regulation in mice. PMID: 22681550
    5. Activation of I1-imidazoline receptor ameliorated energy intake and epididymal white adipose tissue accumulation. PMID: 23516130
    6. Data suggest that both IR1 and IR2 (imidazoline receptor 2) play roles in acquisition of behavioral responses in alcoholism; activation of IR1 and IR2 may serve as molecular targets in prevention (and possibly treatment) of alcoholism. PMID: 23399882
    7. Activation of cerebral I(1)-imidazoline receptor decreased hyperphagia in streptozotocin-induced diabetic mice. PMID: 22674473
    8. Activation of I-1 R may activate FXR to lower plasma lipids, suggesting I-1 R as a new target for the treatment of hyperlipidemia. PMID: 21484668
    9. Report imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. PMID: 18602099
    10. guanidine increases glucose uptake via an activation of imidazoline I2 receptor through AMPK activation in skeletal muscle cell. PMID: 20298750
    11. Nisch regulates cell movement by inhibiting PAK. PMID: 15229651
    12. Data suggest that nischarin, in addition to regulating the p21-activated kinase (PAK) strand of Rac1 signaling, can also regulate other links in the web of Rac1 signaling pathways. PMID: 16002401
    13. Nischarin may serve as the functional I1-receptor PMID: 16678176

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane. Cytoplasm. Early endosome. Recycling endosome.
  • 組織特異性：
    Highly expressed in brain and kidney. Moderately expressed in heart, liver, lung and skeletal muscle. Not detected in spleen and testis.
  • 數據庫鏈接：


主站蜘蛛池模板： 色狠狠色狠狠综合天天| 人人妻人人澡人人爽超污| 亚洲欧美一区二区成人片| 亚洲人成人无码网www国产| 黄网站色视频免费国产| 亚洲精品无码av黄瓜影视 | 久久亚洲精品无码爱剪辑| 精品无人乱码高清| 天堂最新版在线www官网中文地址| 亚洲精品无码久久久| 黑人粗硬进入过程视频| 国产福利视频一区二区| 婷婷色婷婷开心五月| 天堂va欧美va亚洲va好看va| 丰满少妇aaaaaa爰片毛片| 激情按摩系列片aaaa| 麻花传媒在线mv免费观看视频| 老熟女 露脸 嗷嗷叫| 蜜桃av无码免费看永久| 日韩免费无砖专区2020狼| 日韩亚洲欧美中文高清在线| 女人与拘做受全过程免费视频 | 欧美性白人极品hd| 国产精品一区二区在线观看| 99热99这里只有高清国产| 小鲜肉洗澡时自慰网站xnxx| 国产av无码专区亚汌a√| 人人妻人人澡人人爽欧美二区| 24小时日本在线www免费的| 中国人妻被两个老外三p| 亚洲乱码中文字幕小综合| 一本色综合亚洲精品蜜桃冫| 4hu四虎永久免费地址ww416| 成年无码动漫av片在线观看羞羞| 日韩欧美tⅴ一中文字暮| 亚洲欧美日韩综合久久久久久| 欧美日韩视频无码一区二区三| 欧美乱大交xxxxx潮喷| 欧美成人aaaa免费全部观看| 无码专区无码专区视频网址| 超碰国产精品久久国产精品99|