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  4. Recombinant Mouse NUAK family SNF1-like kinase 2 (Nuak2)

Recombinant Mouse NUAK family SNF1-like kinase 2 (Nuak2)

  • 中文名稱：
    小鼠Nuak2重組蛋白
  • 貨號：
    CSB-YP804434MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Nuak2重組蛋白
  • 貨號：
    CSB-EP804434MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Nuak2重組蛋白
  • 貨號：
    CSB-EP804434MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Nuak2重組蛋白
  • 貨號：
    CSB-BP804434MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Nuak2重組蛋白
  • 貨號：
    CSB-MP804434MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Nuak2
  • Uniprot No.：
  • 別名：
    Nuak2; Omphk2; NUAK family SNF1-like kinase 2; EC 2.7.11.1; Omphalocele kinase 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-639
  • 氨基酸序列
    MESVALLQRP SQAPSASALA SESARPLADG LIKSPKPLMK KQAVKRHHHK HNLRHRYEFL ETLGKGTYGK VKKARESSGR LVAIKSIRKD KIKDEQDLLH IRREIEIMSS LNHPHIIAIH EVGRSRLVTV FENSSKIVIV MEYASRGDLY DYISERPRLS ERDARHFFRQ IVSALHYCHQ NGIVHRDLKL ENILLDANGN IKIADFGLSN LYHKGKFLQT FCGSPLYASP EIVNGKPYVG PEVDSWSLGV LLYILVHGTM PFDGQDHKTL VKQISNGAYR EPPKPSDACG LIRWLLMVNP TRRATLEDVA SHWWVNWGYT TGVGEQEALR EGGHPSGDFG RASMADWLRR SSRPLLENGA KVCSFFKQHV PGGGSTVPGL ERQHSLKKSR KENDMAQNLQ GDPAEDTSSR PGKSSLKLPK GILKKKSSTS SGEVQEDPQE LRPVPDTPGQ PVPAVSLLPR KGILKKSRQR ESGYYSSPEP SESGELLDAS DVFVSGDPVE QKSPQASGLL LHRKGILKLN GKFSRTALEG TTPSTFGSLD QLASSHPAAR PSRPSGAVSE DSILSSESFD QLDLPERLPE TPLRGCVSVD NLRGLEQPPS EGLKRWWQES LGDSCFSLTD CQEVTAAYRQ ALGICSKLS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.
  • 基因功能參考文獻：
    1. Using liver cancer as a model, NUAK2 was identified as an essential mediator of YAP-driven hepatomegaly and tumorigenesis in vivo. PMID: 30446657
    2. Data (including data from studies in knockout and transgenic mice) suggest that Nuak2/Snark is involved in both adipose inflammation and energy metabolism in white/brown adipocytes; Nuak2/Snark appears to regulate thermogenesis in brown adipocytes. PMID: 29298809
    3. These findings reveal a critical role for SNARK in myocyte survival and the maintenance of muscle mass with age. PMID: 26690705
    4. NUAK1 and NUAK2 complementarily function in the apical constriction and apico-basal elongation that associate with the dorsolateral hinge point formation in cephalic neural plate during the 5- to 10-somite stages. PMID: 22689267
    5. Data show that SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle. PMID: 20713714
    6. Obesity was a risk factor for colorectal tumorigenesis in Snark(+/-) mice model. PMID: 18307533

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  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
  • 數(shù)據(jù)庫鏈接：


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