在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Muscarinic acetylcholine receptor M4 (Chrm4), partial

Recombinant Mouse Muscarinic acetylcholine receptor M4 (Chrm4), partial

  • 中文名稱：
    Recombinant Mouse Muscarinic acetylcholine receptor M4(Chrm4),partial
  • 貨號：
    CSB-YP005384MO1
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Muscarinic acetylcholine receptor M4(Chrm4),partial
  • 貨號：
    CSB-EP005384MO1
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Muscarinic acetylcholine receptor M4(Chrm4),partial
  • 貨號：
    CSB-EP005384MO1-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Muscarinic acetylcholine receptor M4(Chrm4),partial
  • 貨號：
    CSB-BP005384MO1
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Muscarinic acetylcholine receptor M4(Chrm4),partial
  • 貨號：
    CSB-MP005384MO1
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Chrm4; Chrm-4; Muscarinic acetylcholine receptor M4; Mm4 mAChR
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
  • 基因功能參考文獻(xiàn)：
    1. The findings of this study indicated that the cocaine-like S(D) effects of muscarinic antagonists are primarily mediated through M1 receptors, with a minor contribution of M4 receptors. PMID: 28442355
    2. In the present study, the functional coupling of Gi/o protein-coupled receptors to GalR1, and the CB1 receptor subtype for endocannabinoids were analyzed in the 3xTg-AD mice model of Alzheimer's disease in the prodromal and advanced stages. In addition, the activity mediated by Gi/o protein-coupled M2/4 muscarinic receptor subtypes was also analyzed in brain areas involved in anxiety and cognition. PMID: 27223629
    3. Muscarinic acetylcholine receptor subtype 4 is essential for cholinergic stimulation of duodenal bicarbonate secretion in mice - relationship to D cell/somatostatin PMID: 26084221
    4. Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic Huntington's disease - YAC128 mice. PMID: 26508634
    5. the role of the M4 receptor in alcohol consumption PMID: 25445043
    6. We show that M4 is a major mAChR subtype mediating the cholinergic inhibition of corticostriatal glutamatergic input on both striatonigral and striatopallidal medium spiny neurons (MSNs). PMID: 24528004
    7. The characterization of the orthosteric agonist, iperoxo, at the M(4) receptor. PMID: 24807965
    8. These data support a role for the M4AChR subtype in mediating the antipsychotic-like activity of BuTAC. PMID: 23907402
    9. Presence of M4 mAChR is sufficient and necessary to mediate the carbachol-induced membrane hyperpolarization and inhibition of SpECTs in laterodorsal tegmental nucleus neurons. PMID: 22956788
    10. M4R is involved in regulation of locomotor activity, social behavior, and sensorimotor gating in mice. PMID: 22463818
    11. Reducing M4 receptor signaling altered only select behavioral phenotypes in the Fmr1KO mouse model, suggesting that other targets are involved in the modulation of fragile X behaviors. PMID: 22123412
    12. Chrm4 receptor is located on presynaptic glutamatergic terminals afferent to the recorded pyramidal neuron, thus decreasing glutamate release. PMID: 20600670
    13. The muscarinic M(4) receptor is the functionally predominant subtype in mouse striatum. PMID: 21114972
    14. Different coupling of striatal M(2)/M(4)-mAChRs to the control of DA release in CPu versus NAc suggests targets to influence DA/ACh function differentially between striatal domains. PMID: 20203199
    15. a distinct subpopulation of neuronal M(4) mAChRs plays a critical role in modulating several important dopamine-dependent behaviors. PMID: 20147565
    16. muscarinic analgesia is exclusively mediated by a combination of M(2) and M(4) mAChRs at both spinal and supraspinal sites. PMID: 12391271
    17. M(4) mAChR plays a central role in mediating cholinergic control of keratinocyte migration by endogenous acetylcholine produced by these cells PMID: 12628458
    18. M4 mAChRs modulate dopamine activity in motor tracts and act as inhibitory autoreceptors in striatum. Review. PMID: 12675128
    19. There is a crucial role for M4 receptors in the tonic and phasic regulation of acetylcholine efflux in the hippocampus as well as in cognitive processes. The M4 receptor participates in a tonic regulatory loop contolling basal acetylcholine levels. PMID: 12874603
    20. loss of M4 muscarinic receptor control of cholinergic function effectuates a state of dopaminergic hyperexcitability PMID: 15231726
    21. M4 increases expression of "migratory" integrins; M4 effects resulted from inhibition of the inhibitory pathway involving the adenylyl cyclase-cyclic AMP-protein kinase A pathway PMID: 15263021
    22. This study indicate that both M4 mediate the muscarinic autoinhibition in ACh release in the longitudinal muscle with myenteric plexus preparation of the mouse ileum. PMID: 15574798
    23. M2 and M5 muscarinic receptors but not M4 muscarinic receptor or D2 dopamine receptors are needed for male USV production during male-female interactions PMID: 18382674
    24. Results suggest that GRK5 deficiency leads to a reduced hippocampal ACh release and cholinergic hypofunction by selective impairment of desensitization of presynaptic M2/M4 autoreceptors. PMID: 19478075

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Muscarinic acetylcholine receptor subfamily, CHRM4 sub-subfamily
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 99久久国产露脸精品国产麻豆| 中国浓毛少妇毛茸茸| 大肉大捧一进一出好爽动态图| 51视频国产精品一区二区| 2021久久精品国产99国产精品| 国产成av人片久青草影院| 一本一道久久a久久精品综合| 97人妻精品一区二区三区| 思思99re6国产在线播放| 99精品国产高清一区二区麻豆| 护士人妻hd中文字幕| 麻豆人妻少妇精品无码专区| 天美传媒精品1区2区3区| 在线精品视频一区二区三四| 色妺妺视频网| 国产亚洲精品久久777777| 色一情一乱一伦一区二区三区小说 | 欧美成 人 网 站 免费| 好了av四色综合无码| 波多野结衣av一区二区全免费观看| 日本特黄aaaaaa片在线观看| 日韩欧美mv在线观看免费| 又粗又大内射免费视频小说| 久久精品国产一区二区三区| 国产又爽又黄又刺激的视频| 免费极品av一视觉盛宴| 亚洲欧美一区二区三区日产| 亚洲综合小说专区图片| 午夜精品影视国产一区在线麻豆 | 国产成人亚洲综合无码精品| 重口sm一区二区三区视频| 人成午夜免费大片| 国产精品亚洲综合色区韩国| 国产亚洲情侣一区二区无| 亚洲乱码av中文一区二区软件| 已婚少妇美妙人妻系列| 欧美成人午夜免费全部完| 精品无人区码一码二码三码区别| 国产人成无码视频在线1000| 奇米影视第四色首页| 92国产精品午夜免费福利视频|