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  4. Recombinant Mouse Microsomal triglyceride transfer protein large subunit (Mttp), partial

Recombinant Mouse Microsomal triglyceride transfer protein large subunit (Mttp), partial

  • 中文名稱：
    小鼠Mttp重組蛋白
  • 貨號：
    CSB-YP015209MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Mttp重組蛋白
  • 貨號：
    CSB-EP015209MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Mttp重組蛋白
  • 貨號：
    CSB-EP015209MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Mttp重組蛋白
  • 貨號：
    CSB-BP015209MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Mttp重組蛋白
  • 貨號：
    CSB-MP015209MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Mttp
  • Uniprot No.：
  • 別名：
    Mttp; Mtp; Microsomal triglyceride transfer protein large subunit
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins.; Critical for the development of natural killer T (NKT) cells. Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B.
  • 基因功能參考文獻：
    1. microsomal triglyceride transfer protein, a protein involved in the transfer of lipids onto CD1d, regulates liver natural killer T cell homeostasis in a manner dependent on hepatocyte CD1d. PMID: 28893990
    2. Microsomal triglyceride transfer protein protein plays a critical role in lipid droplet maturation, but does not regulate total body fat accumulation. PMID: 28793320
    3. data provide the first in vivo evidence of the transcriptional regulatory activity of beta-apocarotenoids and identify microsomal triglyceride transfer protein and its transcription factors as the targets of their action. This study demonstrates that beta-carotene induces a feed-forward mechanism in the placenta to enhance the assimilation of beta-carotene for proper embryogenesis. PMID: 27402843
    4. PHARMACOLOGICAL STUDY OF NEW COMPOUNDS ACTING AS REGULATORS OF 18-KDA TRANSLOCATOR PROTEIN LIGANDS PMID: 27159950
    5. Intestine-specific MTP and global ACAT2 deficiency lowers acute cholesterol absorption with chylomicrons and HDLs PMID: 25030663
    6. intestine-specific Mttp deletion is beneficial in young septic mice but harmful in aged mice PMID: 25010671
    7. identified microsomal triglyceride transfer protein, which we show is also under the transcriptional regulation of C/EBPbeta and -delta, as a novel player in the presentation of endogenous lipid antigens by adipocytes PMID: 24966328
    8. effects of reducing either systemic or liver-specific MTP activity on cholesterol metabolism and reverse cholesterol transport PMID: 24511105
    9. Data show that combined deletion of microsomal triglyceride transfer protein (Mttp) and liver fatty acid binding protein 1 (L-Fabp) are protected from lithogenic diet (LD)-induced gallstone formation. PMID: 24474819
    10. FoxO6 is an important signaling molecule upstream of MTP for regulating hepatic VLDL-TG production PMID: 24437489
    11. intestinal MTP and ABCA1 are critical for lipid absorption and are the main determinants of plasma and intestinal lipid levels. PMID: 24019513
    12. Data indicate that plasma lipids, lipid absorption, and microsomal triglyceride transfer protein (MTP), FoxO1, and FoxA2 levels are lower at night and at mealtime in apoAIV-/- mice. PMID: 23729668
    13. defect causes hepatic insulin resistance selective to hepatic glycogen metabolism PMID: 23359250
    14. MTP inhibition increased transcription of the GPT/GOT1 genes through up-regulation of the IRE1alpha/cJun pathway leading to increased synthesis and release of ALT1/AST1 PMID: 23532846
    15. Mttp-IKO mice exhibited protection against sepsis-associated decreases in villus length and intestinal proliferation and were also protected against increased intestinal apoptosis, both central features in control septic mice PMID: 23145105
    16. hepatic LPCAT3 modulates VLDL production by regulating LysoPC levels and MTP expression. PMID: 22511767
    17. LXR agonist treatment caused a paradoxical increase in cholesterol absorption in MTTP-IKO mice and decreased fecal neutral sterol excretion PMID: 22580900
    18. role of Mtp and DGAT2 in hepatic steatosis PMID: 22355095
    19. distinct changes of MTP expression, in correlation with hepatic triglycerides (TG) secretion, underlie the opposite responses of plasma TG levels to high-fat diets in hamsters and mice. PMID: 20510883
    20. reduced MTP is involved in the development of nonalcoholic steatohepatitis PMID: 20392512
    21. Transcriptional and posttranscriptional mechanisms involving NR2F1 and IRE1beta ensure low microsomal triglyceride transfer protein expression in undifferentiated intestinal cells and avoid apolipoprotein B lipoprotein biosynthesis. PMID: 20007910
    22. Required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation. PMID: 12072432
    23. MTP has a role in VLDL assembly but requires low density lipoprotein receptor PMID: 14583618
    24. Conditional deletion of the Mttp gene in hepatocytes is associated with a redistribution of CD1d expression, and Mttp-deleted mice are resistant to immunopathologies associated with invariant NKT cell-mediated hepatitis and colitis. PMID: 15107843
    25. PPARalpha activation stimulates hepatic MTP expression via increased transcription of the Mtp gene PMID: 15537571
    26. MTP is expressed in villus-associated enterocytes along the length of the small intestine. PMID: 15891896
    27. In differentiated 3T3 cells MTP fluorescence was very striking around lipid droplets PMID: 15922333
    28. MTTP involvement in intestinal chylomicron assembly and secretion and suggest that hepatic lipogenesis undergoes compensatory induction in the face of defective intestinal TG secretion. PMID: 16354657
    29. reducing both liver fatty acid binding protein 1 and MTP is an effective means to reduce very low density lipoprotein secretion without causing hepatic steatosis PMID: 16950764
    30. Our findings further indicate that inhibition of hepatic MTTP activity decreases the risk of experimental cholelithiasis by favoring phospholipid output into the bile. PMID: 17064699
    31. An alternate transcript of mttp (MTPv1) is discovered to be the major transcript in hematopoietic cells. In thymocytes, MTPv1 is critical to natural killer T cell development. PMID: 17312007
    32. Modulation of MTP RNA expression may be implicated in the protective effect of YHK in experimental NASH, limiting hepatocyte lipid accumulation. PMID: 17394061
    33. suggest a novel, unexpected role of MTP at a late stage of CD1d trafficking in the lysosomal compartment PMID: 17403933
    34. analysis of diurnal regulation of rat and mouse microsomal triglyceride transfer protein and plasma lipid levels PMID: 17575276
    35. MTP is a target of the transcription factor FoxO1 and excessive VLDL production associated with insulin resistance is caused by the inability of insulin to regulate FoxO1 transcriptional activation of MTP [commentary] PMID: 18497882
    36. FoxO1 mediates insulin regulation of MTP production and augmented MTP levels may be a causative factor for VLDL overproduction and hypertriglyceridemia in diabetes PMID: 18497885
    37. MTP plays a novel role in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins PMID: 18502767
    38. VLDL secretion increased and hepatic TG content decreased following Ad-mMTP administration to human APOB transgenic mice crossed into the Apobec1(-/-) line.. PMID: 18519977
    39. hepatic microsomal TG transfer protein activity by Regulatory effects of arachidonate 5-lipoxygenase in obese mice PMID: 18645210
    40. Perturbations in PTEN not only may influence hepatic insulin signaling and hepatic lipogenesis, but also may alter hepatic apoB-lipoprotein production and the MTP stability. PMID: 19026012
    41. reducing plasma lipid levels by genetic inactivation of the mttp gene in hypercholesterolemic mice with early aortic valve disease normalizes oxidative stress, reduces pro-osteogenic signaling, and halts the progression of aortic valve stenosis. PMID: 19433756

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  • 亞細胞定位：
    Endoplasmic reticulum.; [Isoform 1]: Endoplasmic reticulum. Golgi apparatus.; [Isoform 2]: Endoplasmic reticulum. Golgi apparatus.
  • 組織特異性：
    [Isoform 1]: Mainly expressed in the intestine and the liver, and at lower levels in white and brown fat cells. Expressed in heart.; [Isoform 2]: Ubiquitous, and is the major isoform in hematopoietic cells and adipocytes.
  • 數據庫鏈接：


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