在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Mesoderm posterior protein 2 (Mesp2)

Recombinant Mouse Mesoderm posterior protein 2 (Mesp2)

  • 中文名稱：
    小鼠Mesp2重組蛋白
  • 貨號：
    CSB-YP013710MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Mesp2重組蛋白
  • 貨號：
    CSB-EP013710MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Mesp2重組蛋白
  • 貨號：
    CSB-EP013710MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Mesp2重組蛋白
  • 貨號：
    CSB-BP013710MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Mesp2重組蛋白
  • 貨號：
    CSB-MP013710MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Mesp2
  • Uniprot No.：
  • 別名：
    Mesp2; Mesoderm posterior protein 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-370
  • 氨基酸序列
    MAQSSPPQSL QGLVPLGLLP GLGLGSAIGL HVSGLVLRFV RFLPFYATRR PSQPAGPARS TRTTQATAPR RTRPAPAGGQ RQSASEREKL RMRTLARALQ ELRRFLPPSV APAGQSLTKI ETLRLAIRYI GHLSALLGLS EDSLRRRRRR SADAAFSHRC PQCPDGGSPS QAQMLGPSLG SAMSSGVSWG CPPACPGPLI SPENLGNRIS NVDPRVTPPY CPQIQSPLHQ SLERAADSSP WAPPQACPGM QMSPEPRNKT GHWTQSTEPA ELTKVYQSLS VSPEPRLSLG SPLLLPRPSC QRLQPQPQPQ PQWGCWGHDA EVLSTSEDQG SSPALQLPVA SPTPSSGLQL SGCPELWQED LEGPPLNIFY
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. May play a role with Tcf15 in the differentiation of myotomal and sclerotomal cells by regulating Pax family genes. Controls also the expression of the protocadherin PCDH8/PAPC, EPHA4, RIPPLY2, NOTCH2, FGFR1, and CER1. Binds to the E-boxes within the EPH4A and RIPPLY2 enhancers.
  • 基因功能參考文獻：
    1. conclusion was supported by analyses of Mesp2 KO and Ripply1/2 double KO embryos lacking rostral and caudal properties, respectively PMID: 23727513
    2. current observations of the spatiotemporal disorder of vertebral organogenesis in the Mesp2-null mice provide further insight into the pathogenesis of SCDO and STDO, and the physiological development of the axial skeleton PMID: 23238123
    3. Data demonstrate that Mesp2 is a novel component involved in the suppression of Notch target genes. PMID: 21098559
    4. Data propose a novel function of Notch signaling, in which a progressive oscillating wave of Notch activity is translated into the rostral-caudal polarity of a somite by regulating Mesp2 expression in the anterior presomitic mesoderm. PMID: 20335362
    5. A bHLH-type transcription factor, Mesp2, plays an essential role in somite segmentation in mice. PMID: 11973278
    6. Data describe the genetic interactions between Dll1, Dll3, Mesp2 and Psen1, and the roles of Dll1- and Dll3-Notch pathways, with or without Psen1, in rostrocaudal patterning. PMID: 12900443
    7. Mesp2 is responsible for the rostro-caudal patterning process itself in the anterior presomitic mesoderm, via cellular interaction. PMID: 15677726
    8. developmental protein "wavefront" is generated by suppression of Notch activity by mesoderm posterior 2 (Mesp2) through induction of the lunatic fringe gene (Lfng) PMID: 15902259
    9. Tbx6 directly binds to the Mesp2 gene upstream region and mediates Notch signaling, and subsequent Mesp2 transcription, in the anterior presomitic mesoderm. PMID: 16505380
    10. Forced expression of Mesp2 in somitic cells results in the activation of Epha4. PMID: 16728472
    11. Ripply2-Mesp2 negative-feedback loop is essential for the periodic generation of the rostro-caudal polarity within a somite. PMID: 17360776
    12. patterning events by basic helix-loop-helix-type transcription factors have deep impacts on regional chondrogenic and myogenic differentiation of somitic cells PMID: 17477400
    13. Mesp2 protein leads to the suppression of Tbx6 protein expression post-translationally via rapid degradation mediated by the ubiquitin-proteasome pathway PMID: 18579680
    14. An Mesp2 enhancer knockout mouse bearing mutations in two crucial Tbx6 binding sites does not express Mesp2 in the presomitic mesoderm. PMID: 18849530

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 數據庫鏈接：

    KEGG: mmu:17293

    UniGene: Mm.31472



主站蜘蛛池模板： 最新69成人精品视频免费| 天堂av男人在线播放| 久久久久蜜桃精品成人片| 国语高潮无遮挡无码免费看| 热99re久久精品这里都是精品免费| 与子敌伦刺激对白播放| 国产亚洲欧洲aⅴ综合一区| 日本熟妇浓毛hdsex| 漂亮人妻去按摩被按中出| 久久超碰色中文字幕超清| 亚洲精品av一区在线观看| 国产欧美va欧美va香蕉在线| 国产麻花豆剧传媒精品mv在线| 亚洲成av人在线播放无码| 国产精品亚洲欧美大片在线观看| 成在线人免费视频播放| 九九精品99久久久香蕉| 无码人妻丰满熟妇区五十路百度| 国产白丝无码免费视频| 亚洲色偷偷偷网站色偷一区| 久久99热久久99精品| 色偷偷88888欧美精品久久久| 久久婷婷五月综合色首页| 国产精品久久久久久久伊一| 午夜精品一区二区三区在线观看| 亚洲已满18点击进入在线看片| 国产成人综合95精品视频| 久九九久视频精品免费| 一本色道久久88加勒比—综合| 欧美成人精品手机在线| 欧美成人a天堂片在线观看| 男人狂躁进女人下面免费视频| 精品国产一区二区三区av性色| 无码国产精品一区二区免费vr| 久久精品国产只有精品66| 久久99精品久久久久子伦 | 久久久久欧美国产高潮| 亚洲国产欧美在线观看片不卡| 成人免费毛片aaaaaa片| 一本久久综合亚洲鲁鲁五月天| 久久久久人妻精品区一三寸|