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  4. Recombinant Mouse Membrane metallo-endopeptidase-like 1 (Mmel1), partial

Recombinant Mouse Membrane metallo-endopeptidase-like 1 (Mmel1), partial

  • 中文名稱：
    小鼠Mmel1重組蛋白
  • 貨號：
    CSB-YP014654MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Mmel1重組蛋白
  • 貨號：
    CSB-EP014654MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Mmel1重組蛋白
  • 貨號：
    CSB-EP014654MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Mmel1重組蛋白
  • 貨號：
    CSB-BP014654MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Mmel1重組蛋白
  • 貨號：
    CSB-MP014654MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Mmel1
  • Uniprot No.：
  • 別名：
    Mmel1; Nep2; Nl1; Sep; Membrane metallo-endopeptidase-like 1; EC 3.4.24.11; NEP2(m); Neprilysin II; NEPII; Neprilysin-2; NEP2; NL2; Neprilysin-like 1; NL-1; Neprilysin-like peptidase; NEPLP; Soluble secreted endopeptidase) [Cleaved into: Membrane metallo-endopeptidase-like 1; soluble form; Neprilysin-2 secreted; NEP2(s))]
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond.
  • 基因功能參考文獻：
    1. These studies help to characterize our complex transgenic model of NEP overexpression and further demonstrate NEP's protective effects against plasma extravasation. PMID: 27369050
    2. This study demonstrated that Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the Neprilysin in mice. PMID: 25510509
    3. neprilysin x ABCC1 double-deficient mice present a new model for early effects of amyloid-beta-related mild cognitive impairment that allows investigations without artificial overexpression of inherited Alzheimer's disease genes PMID: 25991605
    4. Data show that intranasal delivery of drugs can be used to model Alzheimer disease and suggest that other phosphoramidon-sensitive peptidases are degrading amyloid beta in neprilysin/NEP2-deficient mice. PMID: 20941644
    5. In NEP/NEP2 double-knockout mice, Abeta levels were marginally increased ( approximately 1.5- to 2-fold), compared with NEP(-/-)/NEP2(+/+) controls. PMID: 21224067
    6. One of the roles of NL1 in mice is related to sperm function. NL1 modulates the processes of fertilization and early embryonic development in vivo. PMID: 15121861
    7. Modification of the structure of the C-terminal region will either impair substrate hydrolysis or completely abolish the secretion and enzymatic activity of the secreted isoform of rat NEP2. PMID: 16081046
    8. Intracellular transport and secretion of NEP2 is regulated by processes such as glycosylation, endoplasmic reticulum-Golgi transport, and intracellular calcium levels. PMID: 18425424

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  • 亞細胞定位：
    Membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form produced by proteolytic cleavage also exists.
  • 蛋白家族：
    Peptidase M13 family
  • 組織特異性：
    Highly expressed in testis. Also expressed in ovary. Weakly or not expressed in brain, lung, heart, liver, kidney, adrenal gland and intestine.
  • 數據庫鏈接：


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